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- Sun, Su Ming, et al. Show all 20 Authors
- Molecular cell 2016 v.63 no.3 pp. 514-525
- drugs; genotoxicity; humans; mutation; neoplasm cells; neoplasms; patients; phosphotransferases (kinases); therapeutics; tumor suppressor genes; yeasts
- ... An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (T ...
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