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- Biehs, Ronja, et al. Show all 9 Authors
- Molecular cell 2017 v.65 no.4 pp. 671-684.e5
- DNA; DNA damage; DNA repair; carcinogenesis; heterochromatin; homologous recombination; resection; tumor suppressor proteins
- ... Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including those localizing to heterochromatic regions or harboring additional lesions at the DSB site, undergo resection prior to repair by c-NHEJ and not alt-NHEJ. Resection-dependent c-NHEJ represents an inducible process during ...
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