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You searched for: Journal name Molecular nutrition & food research Remove constraint Journal name: Molecular nutrition & food research Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Source 2019 v.63 no.9 Remove constraint Source: 2019 v.63 no.9
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1. Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome

Author:
Charlotte C. J. R. Michielsen; Roland W.J. Hangelbroek; Edith J. M. Feskens; Lydia A. Afman
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1801095
ISSN:
1613-4125
Subject:
Mediterranean diet; at-risk population; blood serum; cardiovascular diseases; cholesterol; health effects assessments; lipid composition; low density lipoprotein; metabolic syndrome; metabolites; monounsaturated fatty acids; nuclear magnetic resonance spectroscopy; nutritional intervention; phospholipids; risk reduction; saturated fatty acids; very low density lipoprotein
Abstract:
... SCOPE: The Mediterranean (MED) diet has been associated with a decreased risk of cardiovascular diseases. It is unclear whether this health effect can be mainly contributed to high intakes of monounsaturated fatty acids (MUFA), characteristic for the MED diet, or whether other components of a MED diet also play an important role. METHODS AND RESULTS: A randomized fully controlled parallel trial is ...
DOI:
10.1002/mnfr.201801095
PubMed:
30725537
PubMed Central:
PMC6646913

2. Egg White–Derived Antihypertensive Peptide IRW (Ile‐Arg‐Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1‐7)/Mas Receptor Axis

Author:
Wang Liao; Hongbing Fan; Sandra T. Davidge; Jianping Wu
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1900063
ISSN:
1613-4125
Subject:
adults; animal disease models; antagonists; antihypertensive effect; aorta; blood pressure; body weight; chemokine CCL2; eggs; endothelial nitric oxide synthase; hypertension; inflammation; interleukin-6; males; peptidyl-dipeptidase A; prostaglandin synthase; rats; telemetry; vasodilation
Abstract:
... SCOPE: It is found in the previous study that egg‐white‐derived antihypertensive peptide Ile‐Arg‐Trp (IRW) upregulated angiotensin converting enzyme 2 (ACE2) in spontaneously hypertensive rats (SHRs). The objective of this study is to evaluate the contribution of ACE2 activation by IRW to blood‐pressure‐lowering activity in vivo. METHODS AND RESULTS: Adult male SHRs (13–15 week old) are assigned i ...
DOI:
10.1002/mnfr.201900063
PubMed:
30913349
PubMed Central:
PMC6594022

3. Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

Author:
Chuo Fang; Hyemee Kim; Lora Yanagisawa; William Bennett; Maritza A. Sirven; Robert C. Alaniz; Stephen T. Talcott; Susanne U. Mertens‐Talcott
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1800937
ISSN:
1613-4125
Subject:
Lactobacillus plantarum; bacterial enzymes; biomarkers; brown adipose tissue; chemokine CCL2; enzyme activity; epididymis; fatty-acid synthase; gallic acid; genes; germ-free animals; heat production; high fat diet; inflammation; insulin; insulin resistance; intestinal microorganisms; intestines; leptin; metabolic diseases; metabolites; mice; necrosis; neoplasms; oral administration; pyrogallol; tumor necrosis factor-alpha; white adipose tissue
Abstract:
... SCOPE: Intestinal microbial metabolites from gallotannins (GT), including gallic acid (GA) and pyrogallol (PG), may possess potential anti‐obesogenic properties. Lactobacillus plantarum (L. plantarum) found in the intestinal microbiome encodes for enzymatic activities that metabolize GT into GA and PG. Anti‐obesogenic activities of orally administered GT in the presence or absence of L. plantarum ...
DOI:
10.1002/mnfr.201800937

4. Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High‐Fat‐Diet‐Fed Mice

Author:
Jialin Xu; Tingting Liu; Yuanyuan Li; Wei Liu; Zhanjun Ding; Hang Ma; Navindra P. Seeram; Yu Mu; Xueshi Huang; Liya Li
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1801307
ISSN:
1613-4125
Subject:
Bacteroidetes; Firmicutes; Syzygium cumini; digestive system; dysbiosis; fatty liver; fruit extracts; fruits; high fat diet; insulin resistance; intestinal microorganisms; metabolic diseases; metabolism; mice; microbial communities; nutritional intervention; obesity; ribosomal DNA; short chain fatty acids
Abstract:
... SCOPE: Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In the current study, it is investigated whether a standardized extract from Jamun (Eugenia jambolana), a widely consumed tropical fruit, could alleviate obesity and alter gut microbial community in high‐fat diet (HFD)‐fed mice. METHODS AND RESULTS: C57BL ...
DOI:
10.1002/mnfr.201801307

5. Maternal Supplementation with β‐Carotene During Pregnancy Disturbs Lipid Metabolism and Glucose Homoeostasis in F1 Female Mice

Author:
Jiaojiao Guo; Bingshui Li; Zhenghong Zuo; Meng Chen; Chonggang Wang
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1900072
ISSN:
1613-4125
Subject:
adiponectin; adipose tissue; adults; beta-carotene; blood serum; diabetes; females; gene expression regulation; genes; glucagon; glucose; insulin; insulin receptors; interleukin-6; islets of Langerhans; leptin; lipid metabolism; lipids; liver; males; mice; muscles; obesity; peroxisome proliferator-activated receptor gamma; pregnancy; progeny; resistin; risk factors; visceral fat; vitamin A
Abstract:
... SCOPE: β‐Carotene (BC), a substitute for vitamin A, is widely used for its benefits. The present study investigates whether in‐utero BC administration can alter lipid and glucose homoeostasis in offspring. METHODS AND RESULTS: Pregnant mice are supplemented with BC (1 mg kg⁻¹ weight) by oral gavage once every 3 days, for a total of six doses. Increased visceral fat may be caused by up‐regulated PP ...
DOI:
10.1002/mnfr.201900072

6. Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients

Author:
María Ángeles Ávila‐Gálvez; Rocío García‐Villalba; Francisco Martínez‐Díaz; Beatriz Ocaña‐Castillo; Tamara Monedero‐Saiz; Adela Torrecillas‐Sánchez; Beatriz Abellán; Antonio González‐Sarrías; Juan Carlos Espín
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1801239
ISSN:
1613-4125
Subject:
2,5-dihydroxybenzoic acid; animal tissues; antineoplastic activity; breast neoplasms; breasts; caffeine; chemoprevention; epithelial cells; grape seed extract; lemons; mammary glands; metabolites; metabolomics; methylxanthines; neoplasm cells; olives; patients; polyphenols; pomegranates; resveratrol; surgery; theobromine; urine
Abstract:
... SCOPE: Dietary polyphenols may protect against breast cancer. However, it is unknown whether polyphenols reach human malignant breast tumors in molecular forms and(or) at concentrations likely to act against cancer. METHODS AND RESULTS: Ninteen breast cancer patients consumed three capsules daily from biopsy‐confirmed diagnosis to surgery (6 ± 2 days). The capsules contained pomegranate, orange, l ...
DOI:
10.1002/mnfr.201801239

7. Red and White Wine Lees Show Inhibitory Effects on Liver Carcinogenesis

Author:
Zahira Fernández‐Bedmar; Jaouad Anter; Angeles Alonso‐Moraga; Pilar Delgado de la Torre; María Dolores Luque de Castro; Yolanda Millán‐Ruiz; Marina Sánchez‐Frías; Silvia Guil‐Luna
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1800864
ISSN:
1613-4125
Subject:
DNA methylation; animal models; anticarcinogenic activity; carcinogenesis; carcinogens; chemoprevention; fermentation; hepatoma; hepatoprotective effect; high performance liquid chromatography; in vivo studies; lees; liver; mitosis; physicochemical properties; polyphenols; pyrogallol; sediments; syringic acid; white wines
Abstract:
... SCOPE: Wine has shown anticarcinogenic benefits in hepatocarcinoma and polyphenols seem to be responsible for these effects. Wine lees are the sediments produced during fermentation and they endow wine with organoleptic and physicochemical properties. However, the anticarcinogenic role of these compounds is still unknown. Thus, the purpose of this work is to determine the phytochemical profiles of ...
DOI:
10.1002/mnfr.201800864

8. DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol

Author:
Raphaël Chouinard‐Watkins; R. J. Scott Lacombe; Adam H. Metherel; Mojgan Masoodi; Richard P. Bazinet
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1801224
ISSN:
1613-4125
Subject:
bioavailability; blood lipids; blood serum; brain; cortex; docosahexaenoic acid; esterification; isotope labeling; neurons; phosphatidylcholines; phosphatidylethanolamines; phosphatidylserines; radioactivity; rats; triacylglycerols
Abstract:
... SCOPE: Docosahexaenoic acid (DHA, 22:6n‐3) is crucial for optimal neuronal development and function, but the brain has a poor capacity to synthesize this fatty acid. When consumed acutely esterified to phosphatidylcholine, DHA is more efficient at targeting the brain than when consumed esterified to triacylglycerol. However, the brain DHA bioavailability of other forms of DHA‐containing phospholip ...
DOI:
10.1002/mnfr.201801224

9. Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems

Author:
Isabelle Rohn; Stefanie Raschke; Michael Aschner; Simon Tuck; Doris Kuehnelt; Anna Kipp; Tanja Schwerdtle; Julia Bornhorst
Source:
Molecular nutrition & food research 2019 v.63 no.9 pp. e1801304
ISSN:
1613-4125
Subject:
Caenorhabditis elegans; antioxidant activity; bioavailability; defense mechanisms; dietary nutrient sources; gene expression; gene expression regulation; messenger RNA; metabolism; methylselenocysteine; models; mutants; protective effect; proteins; selenites; selenium; selenomethionine; thioredoxins
Abstract:
... SCOPE: Small selenium (Se) species play a key role in Se metabolism and act as dietary sources of the essential trace element. However, they are redox‐active and trigger pro‐ and antioxidant responses. As health outcomes are strongly species‐dependent, species‐specific characteristics of Se compounds are tested in vivo. METHODS AND RESULTS: In the model organism Caenorhabditis elegans (C. elegans) ...
DOI:
10.1002/mnfr.201801304
PubMed:
30815971
PubMed Central:
PMC6499701