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You searched for: Journal Natural product research Remove constraint Journal: Natural product research Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.33 no.5 Remove constraint Source: 2019 v.33 no.5
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1. A new diarylheptanoid and a new diarylheptanoid glycoside isolated from the roots of Juglans mandshurica and their anti-inflammatory activities

Author:
Diao, Shengbao; Jin, Mei; Sun, Jinfeng; Zhou, Yi; Ye, Chao; Jin, Yong; Zhou, Wei; Li, Gao
Source:
Natural product research 2019 v.33 no.5 pp. 701-707
ISSN:
1478-6427
Subject:
Juglans mandshurica; anti-inflammatory activity; glycosides; heptane; interleukin-6; nitric oxide; nuclear magnetic resonance spectroscopy; roots; tumor necrosis factor-alpha
Abstract:
... A new diarylheptanoid, (2S,3S,5S)-2,3,5-trihydroxy-1,7-bis(4-hydroxy- 3-methoxyphenyl)heptane (1), and a new diarylheptanoid glycoside, (2S,3S,5S)-2,3-dihydroxy-5-O-β-d-xylopyranosyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptane (2), together with three known compounds, rhoiptelol C (3), rhoiptelol B (4) and 3′,4″-epoxy-2-O-β-d-glucopyanosyl-1-(4-hydroxyphenyl)- 7-(3-methoxyphenyl)hepta ...
DOI:
10.1080/14786419.2017.1408100

2. Anti-inflammatory constituents from Psychotria prainii H. Lév

Author:
Tran, Phi Hung; Le, Viet Dung; Do, Thi Ha; Nguyen, Thi Luyen; Nguyen, Phuong Thao; Nguyen, Trong Thong; Nguyen, Tien Dat
Source:
Natural product research 2019 v.33 no.5 pp. 695-700
ISSN:
1478-6427
Subject:
Psychotria; aerial parts; bioactive properties; chemical composition; ethanol; inhibitory concentration 50; nitric oxide; spectroscopy
Abstract:
... One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW ...
DOI:
10.1080/14786419.2017.1408095

3. Antimicrobial and antiparasitic activities of three algae from the northwest coast of Algeria

Author:
Ghania, Aissaoui; Nabila, Belyagoubi-Benhammou; Larbi, Belyagoubi; Elisabeth, Mouray; Philippe, Grellier; Mariem, Benmahdjoub; Khadidja, Kerzabi-Kanoun; Wacila, Benguedda-Rahal; Fawzia, Atik-Bekkara
Source:
Natural product research 2019 v.33 no.5 pp. 742-745
ISSN:
1478-6427
Subject:
Bacillus cereus; Cladostephus; Plasmodium falciparum; Sargassum; Trypanosoma brucei brucei; algae; antiparasitic properties; blood flow; coasts; ethyl acetate; in vitro studies; inhibitory concentration 50; minimum inhibitory concentration; Algeria
Abstract:
... The objective of this study was to investigate the biological activities of Algerian algae, Sargassum vulgare, Cladostephus hirsutus and Rissoella verruculosa. Antimicrobial activity of the crude extracts and their fractions was assessed using the disc diffusion assay, the minimum inhibitory concentration and the minimum bactericidal concentration. Antiparasitic activity was studied in vitro again ...
DOI:
10.1080/14786419.2017.1405403

4. Antiproliferative and cytotoxic secondary metabolites from fruits of Leplaea mayombensis

Author:
Lazare, Sidjui Sidjui; Désiré, Soh; Joel Ebenezer, Dameue Tegang; Brice, Happi Tchakounté; Rufin Marie, Toghueo Kouipou; Alain, Wembe Ngouonpe; Muhammad, Shaiq Ali; Gabriel, Folefoc Ngosong
Source:
Natural product research 2019 v.33 no.5 pp. 635-641
ISSN:
1478-6427
Subject:
Guarea; cytotoxicity; fruits; human cell lines; inhibitory concentration 50; secondary metabolites; spectral analysis; triterpenoids
Abstract:
... Two new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3–12). Structures of the new compounds were elucidated by extensive spectroscopic studies. Except compounds 11 and 12, all the other chemical compounds are newly reported from Leplaea genus. From the results of this investigation, compo ...
DOI:
10.1080/14786419.2017.1402321

5. Assessment of the bioactive compounds, antioxidant and antibacterial activities of Isodon rubescens as affected by drying methods

Author:
Duan, Jiang-Lian; Wu, Ya-Lu; Xu, Jian-Guo
Source:
Natural product research 2019 v.33 no.5 pp. 746-749
ISSN:
1478-6427
Subject:
Isodon rubescens; antibacterial properties; bioactive compounds; flavonoids; freeze drying; phenolic compounds; vacuum drying
Abstract:
... The influence of natural drying (ND), hot-air drying (HD), vacuum drying (VD), infrared drying (ID) and freeze drying (FD) on bioactive compounds and bioactivities of Isodon rubescens (Hemsl.) was investigated in this study. The results showed that different drying methods resulted in the differences in bioactive compositions’ content, antioxidant and antibacterial activities of extracts from I. r ...
DOI:
10.1080/14786419.2017.1405416

6. A syringic acid derivative and two iridoid glycosides from the roots of Stachys geobombycis and their antioxidant properties

Author:
Zhou, Xianli; Huang, Sixin; Wang, Pengcheng; Luo, Qin; Huang, Xiao; Xu, Qin; Qin, Jiangke; Liang, Chengqin; Chen, Xu
Source:
Natural product research 2019 v.33 no.5 pp. 681-686
ISSN:
1478-6427
Subject:
2,2-diphenyl-1-picrylhydrazyl; Stachys; antioxidant activity; inhibitory concentration 50; iridoid glycosides; nuclear magnetic resonance spectroscopy; roots; syringic acid
Abstract:
... A new derivative of syringic acid, stageobester A (1) and two iridoid glycosides which including a new one, stageoboside A (2), were isolated from the roots of Stachys geobombycis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all the isolates were tested for their antioxidant capacity. Compounds 1 and 2 showed moderate ...
DOI:
10.1080/14786419.2017.1405413

7. Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury

Author:
Du, Jie; Wang, Chun-Hua; Yang, Jing; He, Xin; Han, Xiao-Liang; Li, Cong-Cong; Chai, Xin; Wang, Yue-Fei; Zhu, Yan; Li, Zheng
Source:
Natural product research 2019 v.33 no.5 pp. 673-680
ISSN:
1478-6427
Subject:
Cullen corylifolium; chemical composition; flavonoids; fruits; human cell lines; in vitro studies; ionizing radiation; psoralen; radiation injury; radioprotective effect; spectral analysis
Abstract:
... Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. ...
DOI:
10.1080/14786419.2017.1405407

8. Cytotoxicity of new secondary metabolites, fatty acids and tocols composition of seeds of Ducrosia anethifolia (DC.) Boiss

Author:
Oueslati, Med Habib; Bouajila, Jalloul; Belkacem, Med Amine; Harrath, Abdel Halim; Alwasel, Saleh H.; Ben Jannet, Hichem
Source:
Natural product research 2019 v.33 no.5 pp. 708-714
ISSN:
1478-6427
Subject:
Ducrosia anethifolia; cell lines; cytotoxicity; elaidic acid; gas chromatography; methylene chloride; moieties; monoterpenoids; nuclear magnetic resonance spectroscopy; oleic acid; psoralens; secondary metabolites; seed oils; seeds; sesquiterpenoids; spectral analysis; stigmasterol; toxicity testing
Abstract:
... Two new monoterpene Ducrosin A (1) and sesquiterpene Ducrosin B (2) were isolated along with three known compounds, stigmasterol (3) and two furanocoumarins (4 and 5), from the dichloromethane extract of the seeds of Ducrosia anethifolia (DC.) Boiss. Their structures were determined using extensive 1D and 2D NMR, (ES)-HRMS and IR spectroscopic analyses and by comparison with literature data. Gas c ...
DOI:
10.1080/14786419.2017.1408101

9. Effect of Agave americana L. on the human, and Aspergillus oryzae S2 α-amylase inhibitions

Author:
Sahnoun, Mouna; Bejar, Samir; Daoud, Lobna; Ayadi, Leila; Brini, Faiçal; Saibi, Walid
Source:
Natural product research 2019 v.33 no.5 pp. 755-758
ISSN:
1478-6427
Subject:
Agave americana; Aspergillus oryzae; acarbose; alpha-amylase; biocatalysts; enzyme activity; humans; hyperglycemia; in vitro studies; inhibitory concentration 50; p-coumaric acid; starch; therapeutics
Abstract:
... Among phenolic compounds, Agave americana L. extract contained puerarin (38.4%) and p-coumaric acid (12.29%) (pCa). From the Lineweaver–Burk plots, pCa and puerarin demonstrated a competitive and a non competitive inhibitions towards human α-amylase activity, respectively. PCa exhibited a higher human inhibitory activity with an IC₅₀ of 98.8 μM which was about 2.3 times than acarbose. Puerarin (IC ...
DOI:
10.1080/14786419.2017.1408094

10. Effects of Ganoderma, Rhodiola and grape seed extracts on the glucuronidation and oral bioavailability of resveratrol in rats

Author:
Cong, Zhaoqing; Zhou, Man; Yang, Feifei; Liu, Chunyu; Pan, Ruile; Chang, Qi; Liu, Xinmin; Liao, Yonghong
Source:
Natural product research 2019 v.33 no.5 pp. 767-771
ISSN:
1478-6427
Subject:
Ganoderma; Rhodiola; bioavailability; drugs; enzyme activity; glucuronosyltransferases; grape seed extract; grape seeds; models; rats; resveratrol
Abstract:
... Herb extracts were shown to inhibit the activity of UDP-glucuronosyltransferases (UGTs) in vitro. However, the actual in vivo effect of the inhibitory ability on oral bioavailability is yet verified. In this study, resveratrol (RES) was used as a model drug to study the effect of three Chinese herb extracts, Ganoderma, Rhodiola and grape seed, on the in vitro and in vivo inhibition of glucuronidat ...
DOI:
10.1080/14786419.2017.1408099

11. Effects of maternal exposure to extract of Trichilia catigua on antibody production in the offspring of Wistar rats

Author:
Fernandes, Eduardo Vignoto; Ramos, Aline Camargo; dos Santos, Alice Hartmann; Longhini, Renata; Gerardin, Daniela Cristina Cecatto; Venancio, Emerson José
Source:
Natural product research 2019 v.33 no.5 pp. 763-766
ISSN:
1478-6427
Subject:
Trichilia catigua; aluminum hydroxide; antibodies; antibody formation; enzyme-linked immunosorbent assay; females; immunoglobulin G; immunoglobulin Y; males; maternal exposure; mothers; pregnancy; progeny; pups; rats
Abstract:
... It was evaluated the effects of maternal treatment with the Trichilia catigua (ExTc) crude extract on the antibodies’ production by their offspring. Female rats received ExTc or saline from the first day of pregnancy until the twenty-first day after the birth of the pups, when the pups were weaned. All pups were inoculated with two doses of 50 μg of IgY diluted in aluminium hydroxide/PBS on days 2 ...
DOI:
10.1080/14786419.2017.1408097

12. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339

Author:
Cao, Haijing; Liu, Wenjing; Chang, Yuansen; Chen, Hui; Zhang, Yang; Xu, Wenping; Tao, Liming
Source:
Natural product research 2019 v.33 no.5 pp. 659-664
ISSN:
1478-6427
Subject:
Mythimna separata; Streptomyces diastatochromogenes; insecticidal properties; lethal concentration 50; macrolides; spectroscopy
Abstract:
... A new 24-membered macrolide, 5′-epi-SPA-6952A (1), was isolated from the cultured broth of Streptomyces diastatochromogenes. The structure was elucidated by means of spectroscopic methods and comparing with literature data of the known 24-membered macrolide SPA-6952A. Compound 1 was found to show significant insecticidal activity against oriental armyworm(Mythimna separata Walker) with LC₅₀ value ...
DOI:
10.1080/14786419.2017.1405401

13. Ethyl lucidenates A reverses P-glycoprotein mediated vincristine resistance in K562/A02 cells

Author:
Li, Peng; Chen, Shi-yu; Shen, Shao-xin; Liu, Ling-xue; Xu, Jian-hua; Zhang, Zhi-qiang
Source:
Natural product research 2019 v.33 no.5 pp. 732-735
ISSN:
1478-6427
Subject:
P-glycoproteins; cell cycle; drug therapy; multiple drug resistance; neoplasms; rhodamines; vincristine
Abstract:
... Multidrug resistance is a major unresolved obstacle to successful cancer chemotherapy. It is often associated with an elevated efflux of a variety of anticancer drugs by ATP-binding cassette transporters including P-glycoprotein, BCRP and MRP1. In this study, the reversal effect of Ethyl lucidenates A on K562/A02 cells was investigated. At concentrations of 10 μM, Ethyl lucidenates A could reverse ...
DOI:
10.1080/14786419.2017.1402323

14. Health benefits of pistachios consumption

Author:
Terzo, Simona; Baldassano, Sara; Caldara, Gaetano Felice; Ferrantelli, Vincenzo; Lo Dico, Gianluigi; Mulè, Flavia; Amato, Antonella
Source:
Natural product research 2019 v.33 no.5 pp. 715-726
ISSN:
1478-6427
Subject:
anti-inflammatory activity; cardiovascular diseases; diet; energy content; gamma-tocopherol; glycemic control; lutein; noninsulin-dependent diabetes mellitus; nutrients; obesity; phytosterols; pistachios; potassium; unsaturated fatty acids
Abstract:
... The health benefits of nuts, mainly in relation to the improvement of dysmetabolic conditions such as obesity, type 2 diabetes mellitus and the related cardiovascular diseases, have been widely demonstrated. Compared to other nuts, pistachios have a lower fat and caloric content, and contain the highest levels of unsaturated fatty acids, potassium, γ-tocopherol, phytosterols and xanthophyll carote ...
DOI:
10.1080/14786419.2017.1408093

15. Multiple-physiological benefits of bird’s nest fern (Asplenium australasicum) frond extract for dermatological applications

Author:
Zeng, Wen-Wen; Lai, Lih-Shiuh
Source:
Natural product research 2019 v.33 no.5 pp. 736-741
ISSN:
1478-6427
Subject:
Asplenium nidus; birds; clinical trials; collagen; cosmetics; emulsions; fibroblasts; humans; mucilages; p-coumaric acid; skin (animal); tissue repair; water holding capacity
Abstract:
... p-coumaric acid and fucose-rich polysaccharide have been studied for many bio-functions in skin including cutaneous protection from oxidative damage and antiageing, respectively, as well as wound healing. The physiological activities of various bird’s nest fern extracts (BNFE), containing considerable fucose-rich mucilage and p-coumaric acid, on fibroblast and human skin were first investigated. B ...
DOI:
10.1080/14786419.2017.1405400

16. New butyrolactone and other metabolites from the bark of Endlicheria arenosa against of the phytopathogen Colletotrichum tamarilloi

Author:
Albarracín, Lady T.; Delgado, Wilman; Cuca, Luis Enrique; Ávila, Mónica C.
Source:
Natural product research 2019 v.33 no.5 pp. 687-694
ISSN:
1478-6427
Subject:
Colletotrichum; Lauraceae; antifungal properties; bark; chloroform; dodecanoic acid; ethanol; growth inhibitors; hexane; lactones; metabolites; minimum inhibitory concentration; plant pathogens; screening
Abstract:
... In this work, screening of Lauraceae species for their antifungal activity against Collectotrichum tamarilloi was carried out and the ethanol extract derived from the bark of Endlicheria arenosa was found to be the best candidate. From the ethanolic extract of the bark of E. arenosa, the hexane and chloroform fractions were found to be active, from these five fatty acids were identified and two la ...
DOI:
10.1080/14786419.2017.1408090

17. New chemical constituents from the fruits of Zanthoxylum armatum and its in vitro anti-inflammatory profile

Author:
Nooreen, Zulfa; Kumar, Anant; Bawankule, Dnyaneshwar Umrao; Tandon, Sudeep; Ali, Mohd; Xuan, Tran Dang; Ahmad, Ateeque
Source:
Natural product research 2019 v.33 no.5 pp. 665-672
ISSN:
1478-6427
Subject:
Zanthoxylum armatum; anti-inflammatory activity; benzene; chemical composition; chemical structure; dose response; fruits; interleukin-6; macrophages; mice; palmitic acid; phenylacetic acid; spectroscopy; tumor necrosis factor-alpha
Abstract:
... Chemical investigations on the fruits of Zanthoxylum armatum Roxb. (Rutaceae) led to the isolation of two new constituents characterised as 2α-methyl-2β-ethylene-3β-isopropyl-cyclohexan-1β, 3α-diol (1) and phenol-O-β-D-arabinopyranosyl-4′-(3″, 7″, 11″, 15″-tetramethyl)-hexadecan-1″-oate (2) along with known compounds m-methoxy palmityloxy benzene (3), acetyl phenyl acetate (4), linoleiyl-O-α-D-xyl ...
DOI:
10.1080/14786419.2017.1405404

18. Polyphenolic characterisation of plant mixture (Lisosan® Reduction) and its hypocholesterolaemic effect in high fat diet-fed mice

Author:
Russo, Rossella; Pucci, Laura; Giorgetti, Lucia; Árvay, Július; Vizzarri, Francesco; Longo, Vincenzo; Pozzo, Luisa
Source:
Natural product research 2019 v.33 no.5 pp. 651-658
ISSN:
1478-6427
Subject:
Desmodium; Hordeum vulgare; Malus domestica; Picrorhiza kurrooa; Triticum aestivum; blood serum; cholesterol; ferulic acid; gene expression; glucose; high fat diet; high performance liquid chromatography; mice; polyphenols; sinapic acid; syringic acid; triacylglycerols
Abstract:
... Lisosan® Reduction is a plant mixture produced from powder of fermented Triticum aestivum (Lisosan® G), Desmodium adscendens, Malus domestica, Picrorhiza kurroa and Hordeum vulgare. The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogeni ...
DOI:
10.1080/14786419.2017.1402328

19. Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Author:
Tiam, Eric Robert; Ngono Bikobo, Dominique Serge; Abouem A Zintchem, Auguste; Mbabi Nyemeck, Norbert; Moni Ndedi, Esther Del Florence; Betote Diboué, Patrick Hervé; Nyegue, Maximilienne Ascension; Atchadé, Alex de Théodore; Emmanuel Pegnyemb, Dieudonné; Bochet, Christian G.; Koert, Ulrich
Source:
Natural product research 2019 v.33 no.5 pp. 642-650
ISSN:
1478-6427
Subject:
Mycobacterium tuberculosis; Triclisia; aerial parts; antibacterial properties; minimum inhibitory concentration; myricetin; nuclear magnetic resonance spectroscopy; quercetin; secondary metabolites; spectral analysis; stigmasterol
Abstract:
... Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), ...
DOI:
10.1080/14786419.2017.1402324

20. Study on the activity and mechanism of skimmianine against human non-small cell lung cancer

Author:
Zuo, Yangsong; Pu, Juan; Chen, Guiming; Shen, Wenyi; Wang, Baoran
Source:
Natural product research 2019 v.33 no.5 pp. 759-762
ISSN:
1478-6427
Subject:
apoptosis; humans; lung neoplasms
Abstract:
... The present research was to investigate the effects of skimmianine (SK) in four non-small cell lung cancer (NSCLC) cells. We found that SK can significantly inhibit the growth of NSCLC cells and markedly induce apoptosis in NSCLC cells. The effects of growth inhibition and apoptosis induction were in a concentration–response relationship and caspase-dependent manner. ...
DOI:
10.1080/14786419.2017.1408096