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- Author:
- Stanimirovic, Bojana; Vujovic, Dragan; Pejin, Boris; Popovic Djordjevic, Jelena; Maletic, Radojka; Raicevic, Petar; Tesic, Zivoslav
- Source:
- Natural product research 2019 v.33 no.8 pp. 1209-1213
- ISSN:
- 1478-6427
- Subject:
- Alzheimer disease; aluminum; breeding; chromium; copper; dietary supplements; humans; ingredients; iron; lead; leaves; manganese; neurodegenerative diseases; nickel; potassium; sodium; toxicity; viticulture; zinc; Serbia
- Abstract:
- ... The elemental profile of the leaf samples of three Cabernet Franc clone candidates recently developed in Serbia (Nos. 02, 010 and 012) obtained in the last phase of clonal selection was examined within this study by ICP-OES. Optimal content of Al, Fe, Cu and Zn, the metals well known for their links with a number of neurodegenerative disorders including Alzheimer’s disease, has actually highlighte ...
- DOI:
- 10.1080/14786419.2018.1457671
-
http://dx.doi.org/10.1080/14786419.2018.1457671
- Author:
- Posri, Priyapan; Suthiwong, Jittra; Takomthong, Pitchayakarn; Wongsa, Chatchawan; Chuenban, Chindawadee; Boonyarat, Chantana; Yenjai, Chavi
- Source:
- Natural product research 2019 v.33 no.8 pp. 1115-1121
- ISSN:
- 1478-6427
- Subject:
- Alzheimer disease; Atalantia; acetylcholinesterase; antioxidant activity; flavonoids; hydroxybenzaldehyde; leaves
- Abstract:
- ... A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer’ ...
- DOI:
- 10.1080/14786419.2018.1457667
-
http://dx.doi.org/10.1080/14786419.2018.1457667
- Author:
- Hassan, Ahmed R.; Amer, Khadiga F.; El-Toumy, Sayed A.; Nielsen, John; Christensen, Søren Brøgger
- Source:
- Natural product research 2019 v.33 no.8 pp. 1135-1139
- ISSN:
- 1478-6427
- Subject:
- Taverniera; aerial parts; formononetin; glycosides; isorhamnetin; kaempferol
- Abstract:
- ... Isolation of flavonoids from the aerial parts of Taverniera aegyptiaca Bioss. (Fabaceae) led to identification of one new flavonol glycoside, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (1), along with eleven compounds, which previously have not been isolated from this plant quercetin-3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside] (2), isorhamn ...
- DOI:
- 10.1080/14786419.2018.1460834
-
http://dx.doi.org/10.1080/14786419.2018.1460834
- Author:
- Zhao, Hongmei; Chen, Lijun; Yang, Yiyu; Zhang, Yan; Chen, Yegao
- Source:
- Natural product research 2019 v.33 no.8 pp. 1158-1161
- ISSN:
- 1478-6427
- Subject:
- Lotus corniculatus; cytotoxicity; glucosides; humans; neoplasms; phenolic compounds; spectral analysis
- Abstract:
- ... A new galloyl glucoside, 2,6-di-O-acetyl 1-O-galloyl β-D-glucose (1), along with five known phenolic compounds were isolated from the whole plants of Lotus corniculatus. Their structures were elucidated by means of extensive spectroscopic analysis. Compound 1 was assessed for its cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it ...
- DOI:
- 10.1080/14786419.2018.1460839
-
http://dx.doi.org/10.1080/14786419.2018.1460839
- Author:
- Ding, Jian-Hai; Li, Zheng-Hui; Feng, Tao; Liu, Ji-Kai
- Source:
- Natural product research 2019 v.33 no.8 pp. 1223-1226
- ISSN:
- 1478-6427
- Subject:
- 11-beta-hydroxysteroid dehydrogenase; fungi; isozymes; nuclear magnetic resonance spectroscopy; sesquiterpenoids
- Abstract:
- ... A new guaiane sesquiterpene (1) was isolated from cultures of the fungus Fulvifomes kanehirae. Its structure was elucidated by spectroscopic methods including extensive 2D-NMR techniques. Meanwhile, the compound was tested for its inhibitory activity against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). ...
- DOI:
- 10.1080/14786419.2018.1463529
-
http://dx.doi.org/10.1080/14786419.2018.1463529
- Author:
- Nguyen, Hien Minh; Ito, Takuya; Win, Nwet Nwet; Vo, Hung Quoc; Nguyen, Hoai Thi; Morita, Hiroyuki
- Source:
- Natural product research 2019 v.33 no.8 pp. 1175-1181
- ISSN:
- 1478-6427
- Subject:
- Porifera; breast neoplasms; chemical structure; cytotoxicity; fibroblasts; human cell lines; humans; inhibitory concentration 50; lung neoplasms; neoplasm cells; spectral analysis; sterols; uterine cervical neoplasms; Vietnam
- Abstract:
- ... A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer c ...
- DOI:
- 10.1080/14786419.2018.1465057
-
http://dx.doi.org/10.1080/14786419.2018.1465057
- Author:
- Rakotonandrasana, Stephan R.; Rabehaja, Delphin J. R.; Paoli, Mathieu; de Rocca Serra, Dominique; Andrianjara, Charles; Bighelli, Ange; Ramanoelina, Panja A. R.; Tomi, Félix
- Source:
- Natural product research 2019 v.33 no.8 pp. 1200-1203
- ISSN:
- 1478-6427
- Subject:
- Apiaceae; aerial parts; chemical composition; dill; essential oils; gas chromatography-mass spectrometry; indigenous species; nuclear magnetic resonance spectroscopy; oils; sales; statistical analysis; terpinolene
- Abstract:
- ... The chemical composition of twenty-five essential oil samples from the aerial parts of two Malagasy endemic species Billburttia capensoides Sales & Hedge and B. vaginoides Sales & Hedge, were investigated for the first time. Based on chromatographic profiles, three selected samples were investigated using GC(RI), GC-MS and ¹³C NMR. The content of the main components varied drastically from sample ...
- DOI:
- 10.1080/14786419.2018.1457669
-
http://dx.doi.org/10.1080/14786419.2018.1457669
- Author:
- Bruno, Maurizio; Modica, Aurora; Catinella, Giorgia; Canlı, Cem; Arasoglu, Tülin; Çelik, Sezgin
- Source:
- Natural product research 2019 v.33 no.8 pp. 1092-1100
- ISSN:
- 1478-6427
- Subject:
- Centaurea; aerial parts; antifungal properties; chemical composition; essential oils; gas chromatography-mass spectrometry; microorganisms; palmitic acid; spathulenol; Turkey (country)
- Abstract:
- ... In the present study the chemical composition of the essential oils from aerial parts of Centaurea tomentella Hand.-Mazz. and C. haussknechtii Boiss. collected in Turkey was evaluated by GC and GC-MS. The main components of C. tomentella L. were hexadecanoic acid (19.7%), caryophyllene oxide (6.6%) and spathulenol (4.8%) whereas C. haussknechtii was rich in hexadecanoic acid (26.2%), (Z,Z)-9,12-oc ...
- DOI:
- 10.1080/14786419.2018.1463531
-
http://dx.doi.org/10.1080/14786419.2018.1463531
- Author:
- Burman, Rohani Prasad; Gupta, Shantanu; Bhatti, Jyoti; Verma, Krishan; Rajak, Devendra; Gill, Manjinder Singh
- Source:
- Natural product research 2019 v.33 no.8 pp. 1147-1157
- ISSN:
- 1478-6427
- Subject:
- Streptomyces; benzaldehyde; cytotoxicity; demethylation; methylation
- Abstract:
- ... First total synthesis of carpatamide-A 7a, cytotoxic arylamine derivative isolated from marine derived Streptomyces sp., was achieved in twelve steps with overall yield of 24% with seven longest linear steps. In the penultimate step, dienoic acid 13 and an amino-phenylpropionic acid methyl ester core 21 were coupled to synthesize methylated derivativative of carpatamide-A 22 followed by demethylat ...
- DOI:
- 10.1080/14786419.2018.1460837
-
http://dx.doi.org/10.1080/14786419.2018.1460837
- Author:
- Chen, Jun; Chen, Jianwei; Wang, Sijia; Zhou, Guangmin; Chen, Danqing; Zhang, Huawei; Wang, Hong
- Source:
- Natural product research 2019 v.33 no.8 pp. 1122-1126
- ISSN:
- 1478-6427
- Subject:
- aquatic bacteria; detection limit; green chemistry; reversed-phase high performance liquid chromatography; salinity; screening; solutes; temperature; wavelengths
- Abstract:
- ... A novel, green, rapid, and precise polar RP-HPLC method has been successfully developed and screened for ectoine high-yield strain in marine bacteria. Ectoine is a polar and extremely useful solute which allows microorganisms to survive in extreme environmental salinity. This paper describes a polar-HPLC method employed polar RP-C18 (5 μm, 250 × 4.6 mm) using pure water as the mobile phase and a c ...
- DOI:
- 10.1080/14786419.2018.1457668
-
http://dx.doi.org/10.1080/14786419.2018.1457668
- Author:
- Zhu, Jing Xuan; Ding, Lijian; He, Shan
- Source:
- Natural product research 2019 v.33 no.8 pp. 1191-1195
- ISSN:
- 1478-6427
- Subject:
- Aspergillus versicolor; Staphylococcus aureus; biphenyl; enzyme inhibitors; epigenetics; fungi; histone deacetylase; secondary metabolites; spectral analysis
- Abstract:
- ... Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The str ...
- DOI:
- 10.1080/14786419.2018.1465423
-
http://dx.doi.org/10.1080/14786419.2018.1465423
- Author:
- Mulinacci, Nadia; Valletta, Alessio; Pasqualetti, Valentina; Innocenti, Marzia; Giuliani, Camilla; Bellumori, Maria; De Angelis, Giulia; Carnevale, Alessia; Locato, Vittoria; Di Venanzio, Cristina; De Gara, Laura; Pasqua, Gabriella
- Source:
- Natural product research 2019 v.33 no.8 pp. 1106-1114
- ISSN:
- 1478-6427
- Subject:
- antioxidant activity; ascorbic acid; dietary supplements; humans; ionizing radiation; irradiation; oxidative stress; phenols; phytochemicals; plant byproducts; plant extracts; radiotherapy
- Abstract:
- ... Humans are exposed to ionizing radiations in medical radiodiagnosis and radiotherapy that cause oxidative damages and degenerative diseases. Airplane pilots, and even more astronauts, are exposed to a variety of potentially harmful factors, including cosmic radiations. Among the phytochemicals, phenols are particularly efficient in countering the oxidative stress. In the present study, different e ...
- DOI:
- 10.1080/14786419.2018.1457663
-
http://dx.doi.org/10.1080/14786419.2018.1457663
- Author:
- Wang, Zhi-Wei; Li, Yun; Liu, Da-Hui; Mu, Yan; Dong, Hong-Jing; Zhou, Hong-Lei; Guo, Lan-Ping; Wang, Xiao
- Source:
- Natural product research 2019 v.33 no.8 pp. 1140-1146
- ISSN:
- 1478-6427
- Subject:
- Gastrodia elata; cell death; median effective concentration; neuroprotective effect; phenolic compounds; rhizomes
- Abstract:
- ... Four new gastrodin derivatives containing a trans-cinnamoyl unit (1–4) and nine known compounds (5–13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC₅₀ values of 10.5 and 10.2 μM, respectively. ...
- DOI:
- 10.1080/14786419.2018.1460836
-
http://dx.doi.org/10.1080/14786419.2018.1460836
- Author:
- Yang, Dan; Jia, Xuchao; Xie, Haihui
- Source:
- Natural product research 2019 v.33 no.8 pp. 1233-1236
- ISSN:
- 1478-6427
- Subject:
- Averrhoa carambola; acetylcholinesterase; alpha-glucosidase; enzyme inhibition; fruits; glycosides; rutin; spectroscopy; triacylglycerol lipase
- Abstract:
- ... Two new alkyl glycosides, heptyl vicianoside (1) and methyl 2-O-β-d-fucopyranosyl-α-l-arabinofuranoside (methyl caramboside, 4), were isolated from the sour fruit of Averrhoa carambola L. (Oxalidaceae), along with octyl vicianoside (2), cis-3-hexenyl rutinoside (3), and methyl α-d-fructofuranoside (5). Their structures were determined by spectroscopic and chemical methods. Compounds 2, 3, and 5 we ...
- DOI:
- 10.1080/14786419.2018.1466123
-
http://dx.doi.org/10.1080/14786419.2018.1466123
- Author:
- Markowski, Michał; Długosz, Marek; Szakiel, Anna; Durli, Mathieu; Poinsignon, Sophie; Bouguet-Bonnet, Sabine; Vernex-Loset, Lionel; Krier, Gabriel; Henry, Max
- Source:
- Natural product research 2019 v.33 no.8 pp. 1218-1222
- ISSN:
- 1478-6427
- Subject:
- Calendula officinalis; Rhizobium rhizogenes; biosynthesis; desmosides; flowers; glucosides; glycosylation; high performance liquid chromatography; indigenous species; jasmonic acid; matrix-assisted laser desorption-ionization mass spectrometry; moieties; nuclear magnetic resonance spectroscopy; oleanolic acid; plant stress; plants (botany); roots; sugars
- Abstract:
- ... Native plant of marigold (Calendula officinalis L.) synthesizes oleanolic acid saponins classified as glucosides or glucuronides according to the first residue in sugar chain bound to C-3 hydroxyl group. Hairy root culture, obtained by transformation with Agrobacterium rhizogenes strain 15834, exhibit a potent ability of synthesis of oleanolic acid glycosides. The HPLC profile of saponin fraction ...
- DOI:
- 10.1080/14786419.2018.1460840
-
http://dx.doi.org/10.1080/14786419.2018.1460840
- Author:
- Zhang, Liwen; Bai, Yongliang; Su, Shulan; Ouyang, Zhen; Liu, Li; Pan, Gang; Qian, Dawei; Duan, Jinao
- Source:
- Natural product research 2019 v.33 no.8 pp. 1182-1190
- ISSN:
- 1478-6427
- Subject:
- alkaloids; fagomine; instars; leaves; metabolism; mulberries; quantitative analysis; silkworms
- Abstract:
- ... Metabolism, transformation and dynamic changes of DNJ, 2-O-α-D-Gal-DNJ, fagomine, isofagomine and 4-O-β-d-Glc-fagomine from mulberry leaves in silkworms at different instars were observed. UPLC-Q/TOF-MS and UPLC-TQ/MS methods were adopted for qualitative and quantitative analysis respectively. Three species mulberry leaves were used to feed the silkworm as controls. By analyzing and comparing the ...
- DOI:
- 10.1080/14786419.2018.1465422
-
http://dx.doi.org/10.1080/14786419.2018.1465422
- Author:
- Tomassini, A.; Curone, G.; Solè, M.; Capuani, G.; Sciubba, F.; Conta, G.; Miccheli, A.; Vigo, D.
- Source:
- Natural product research 2019 v.33 no.8 pp. 1085-1091
- ISSN:
- 1478-6427
- Subject:
- biodiversity; breeds; cows; diet; farms; genetic background; industry; late lactation; metabolites; metabolomics; milk; milk composition; milk quality; nuclear magnetic resonance spectroscopy; nutritive value; races; Italy
- Abstract:
- ... It is well established that different factors affect milk composition in cows and that milk composition, in turn, affect both technological and nutritional qualities. In this respect the comprehension of the metabolic variability of milk composition in relation to the lactation time as well as to the genetic background may be of paramount importance for the agri-food industries. In the present stu ...
- DOI:
- 10.1080/14786419.2018.1462183
-
http://dx.doi.org/10.1080/14786419.2018.1462183
- Author:
- Gonçalves, Renato Sonchini; César, Gabriel Batista; Barbosa, Patrícia Magalhães; Hioka, Noboru; Nakamura, Celso Vataru; Bruschi, Marcos Luciano; Caetano, Wilker
- Source:
- Natural product research 2019 v.33 no.8 pp. 1196-1199
- ISSN:
- 1478-6427
- Subject:
- Hypericum; emodin; hypericin; photosensitizing agents; reducing agents; screening; spectroscopy
- Abstract:
- ... Emodin reduction to emodin anthrone comprise one of three process steps involved in the hypericin synthesis, a powerful natural photosensitiser found in plants of the genus Hypericum. In this communication, an optimized protocol was established for emodin reduction enabling an efficient multigram preparation of emodin anthrone. A screening of reducing agent (SnCl₂·2H₂O and HClcₒₙc) under different ...
- DOI:
- 10.1080/14786419.2018.1457661
-
http://dx.doi.org/10.1080/14786419.2018.1457661
- Author:
- Francis, Sajin K.; James, Beena; Varughese, Sunil; Nair, Mangalam S.
- Source:
- Natural product research 2019 v.33 no.8 pp. 1204-1208
- ISSN:
- 1478-6427
- Subject:
- Myristica fragrans; bark; beta-sitosterol; crystal structure; lignans; spectroscopy; spices; tetrahydrofuran; India; Indonesia; South Africa; Sri Lanka
- Abstract:
- ... Myristica fragrans Houtt., the source of very important spice ‘nutmeg’ used world over is native to India, Indonesia, Sri Lanka, South Africa and Southeast Asia. Phytochemical investigation of M. fragrans stem bark led to the isolation of bis-aryl dimethyl tetrahydrofuran lignans, such as grandisin [(7S,8S,7′S,8′S)-3,3′,4,4′,5,5′-hexamethoxy-7,7′,8,8′-lignan] and (7S,8S,7′R,8′R)-3,3′,4,4′,5,5′-hex ...
- DOI:
- 10.1080/14786419.2018.1457670
-
http://dx.doi.org/10.1080/14786419.2018.1457670
- Author:
- Liu, Yan-Ping; Wen, Qing; Hu, Shi; Ma, Yan-Lei; Jiang, Zhi-Hua; Tang, Jin-Ying; Fu, Yan-Hui
- Source:
- Natural product research 2019 v.33 no.8 pp. 1169-1174
- ISSN:
- 1478-6427
- Subject:
- cytotoxicity; diterpenoids; human cell lines; humans; inhibitory concentration 50; leaves; neoplasm cells; phytochemicals; spectroscopy; stems
- Abstract:
- ... Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2–8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was eva ...
- DOI:
- 10.1080/14786419.2018.1462184
-
http://dx.doi.org/10.1080/14786419.2018.1462184