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- Lee, Ik-Soo, et al. Show all 2 Author
- Natural product research 2017 v.31 no.8 pp. 883-889
- Absidia coerulea; Penicillium chrysogenum; antineoplastic activity; artemisinin; beneficial microorganisms; biotransformation; chemical structure; metabolites; oxidation; spectroscopy
- ... Dihydroartemisinin (DHA, 1), a sesquiterpene endoperoxide derived from artemisinin, has shown potent antimalarial and anticancer activities. Microbial transformation of DHA by Absidia coerulea and Penicillium chrysogenum yielded one new (3) and four known metabolites (2 , 4 – 6). The chemical structures of these compounds were identified as deoxydihydroartemisinin (2), 8α-hydroxydeoxyartemisinin ( ...