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- Farshad Darvishi; Jacqueline Destain; Iraj Nahvi; Philippe Thonart; Hamid Zarkesh-Esfahani
- New biotechnology 2011 v.28 no.6 pp. 756-760
- recombinant DNA, etc ; Yarrowia lipolytica; bioreactors; carboxylic ester hydrolases; ethyl methanesulfonate; genes; hydrophobicity; molecular weight; mutants; mutation; oleic acid; open reading frames; pH; promoter regions; selective media; sequence analysis; temperature; value-added products; yeasts; Show all 19 Subjects
- ... The yeast Yarrowia lipolytica degrades efficiently low-cost hydrophobic substrates for the production of various added-value products such as lipases. To obtain yeast strains producing high levels of extracellular lipase, Y. lipolytica DSM3286 was subjected to mutation using ethyl methanesulfonate (EMS) and ultraviolet (UV) light. Twenty mutants were selected out of 1600 mutants of Y. lipolytica t ...
- Achim Rothe; Andrea Rubbert
- New biotechnology 2011 v.28 no.5 pp. 502-510
- recombinant DNA, etc ; anti-inflammatory agents; clinical trials; inflammation; pharmacokinetics; recombinant antibodies; recombinant proteins; technology; therapeutics; Show all 9 Subjects
- ... New targeted anti-inflammatory drugs have revolutionized the therapeutic strategies in rheumatology. Recombinant DNA selection technologies have enabled the isolation and humanization of specific antibody fragments of any specificity that can be ‘armed’ to deliver effective anti-inflammatory ‘payloads’. Antibodies and other targeted provide the opportunity to block key soluble mediators ...