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- Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
- Nucleic acids research 2008 v.36 no.20 pp. 6343-6354
- 6-aminohexanoic acid; animal models; cell culture; cytotoxicity; heparan sulfate; heparin; hybridization; hydrophobicity; muscular dystrophy; nucleic acids; oligonucleotides; peptides; ribonucleases; structure-activity relationships; variance
- ... Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompetent oligonucleotide analogs such as phosphoramidate morpholino oligonucleotides (PMO) might lead to important clinical applications. Chemical conjugation of PMO to arginine-rich cell penetrating peptides (CPP) such as (R-Ahx-R)₄ (with Ahx standing for 6-aminohexanoic acid) leads to sequence-specific spl ...
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