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You searched for: Author "Chakraborty, Prasun" Remove constraint Author: "Chakraborty, Prasun" Journal Nucleic acids research Remove constraint Journal: Nucleic acids research
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1. WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase

Author:
Chakraborty, Prasun,   et al.   ; Grosse, Frank;     Show all 2 Author
Source:
Nucleic acids research 2010 v.38 no.14 pp. 4722-4730
ISSN:
0305-1048
Subject:
DNA helicases; DNA repair; DNA replication; RNA helicases; genes; humans; hybrids; mutation; neoplasms; nuclear genome; nucleic acids; protein-protein interactions; transcription (genetics)
Abstract:
... Mutations in the Werner gene promote the segmental progeroid Werner syndrome (WS) with increased genomic instability and cancer. The Werner gene encodes a DNA helicase (WRN) that can engage in direct protein-protein interactions with DHX9, also known as RNA helicase A or nuclear DNA helicase II, which represents an essential enzyme involved in transcription and DNA repair. By using several synthet ...
DOI:
10.1093/nar/gkq240
PubMed:
20385589
PubMed Central:
PMC2919725