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- Pence, B.C.; Landers, M.; Dunn, D.M.; Shen, C.L.; Miller, M.F.
- Nutrition and cancer 1998 v.30 no.3 pp. 220-226
- dietary fat; food composition; carcinogens; cooking; tallow; carcinogenesis; long term experiments; stomach; incidence; colon; body weight; adenocarcinoma; heterocyclic nitrogen compounds; duration; rats; temperature; experimental diets; beef; animal models
- ... Epidemiologic studies have linked the consumption of red meat and the consumption of highly browned meats containing high levels of heterocyclic aromatic amines (HCAs) to increased risk of colorectal cancer or polyps. The present study determined the effects of long-term feeding of beef-containing diets with low and high levels of HCAs (in the context of a low or high beef tallow diet) on a standa ...
- Caderni, G.; Luceri, C.; Lancioni, L.; Tessitore, L.; Dolara, P.
- Nutrition and cancer 1998 v.30 no.3 pp. 175-181
- nutrient intake; dietary fat; experimental diets; cell division; animal models; intestinal mucosa; carcinogens; rats; azoxymethane; dietary supplements; oral administration; apoptosis; colon
- ... We investigated whether sodium butyrate, administered orally as gastroresistant slow-release pellets to rats, could affect markers of colon carcinogenesis. F344 male rats were fed a high-fat diet (230 g/kg corn oil, wt/wt) and treated with two injections (1 wk apart) of azoxymethane (15 mg/kg sc) or saline. Rats were then divided into two groups: one received the diet with 1.5% (wt/wt) sodium buty ...