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1. Suppressive effects of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats

Author:
Okuno, M.,   et al.   ; Tanaka, T.; Komaki, C.; Nagase, S.; Shiratori, Y.; Muto, Y.; Kajiwara, K.; Maki, T.; Moriwaki, H.;     Show all 9 Authors
Source:
Nutrition and cancer 1998 v.30 no.3 pp. 186-193
ISSN:
0163-5581
Subject:
fatty acids; dietary fat; animal proteins; safflower oil; tallow; carcinogenesis; nitrosamines; glutathione transferase; gene expression; adenoma; incidence; phospholipids; weight; messenger RNA; Perilla; body weight; olive oil; rats; food intake; liver; experimental diets; carcinoma; beef; animal models
Abstract:
... We have investigated the modulating effects of low amounts of dietary oils rich in polyunsaturated fatty acids (PUFA) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male F344 rats. A total of 112 animals were divided into eight groups. Groups 1-4 were given drinking water containing 40 ppm DEN for five weeks. Groups 5-8 served as controls without DEN treatment. Groups 1 and 5 were fed ...
DOI:
10.1080/01635589809514662