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1. Absence of an inhibitory effect of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis in rats fed low- or high-fat diets

Author:
Rijnkels, J.M.; Hollanders, V.M.H.; Woutersen, R.A.; Koeman, J.H.; Alink, G.M.
Source:
Nutrition and cancer 1998 v.30 no.2 pp. 124-129
ISSN:
0163-5581
Subject:
rats,   etc   ; carcinogenesis; nutrient intake; food intake; duodenum; dietary fat; experimental diets; adenocarcinoma; body weight; cecum; azoxymethane; jejunum; animal models; adenoma; colorectal neoplasms; vegetables; mixtures; incidence; dietary supplements;     Show all 19 Subjects
Abstract:
... The potential inhibitory effects of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis were examined in rats fed low- or high-fat diets. Rats were fed low-fat diets (20 energy percent, Diets A and B) or high-fat diets (40 energy percent, Diets C and D), supplemented with a vegetables-fruit mixture (19.5% wt/wt, Diets B and D) or unsu ...
DOI:
10.1080/01635589809514651
PubMed:
9589430

2. Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines

Author:
Shen, C.L.; Purewal, M.; San Francisco, S.; Pence, B.C.
Source:
Nutrition and cancer 1998 v.30 no.3 pp. 227-231
ISSN:
0163-5581
Subject:
rats,   etc   ; beef; heterocyclic nitrogen compounds; cooking; temperature; DNA; liver; colon; stomach; mutagenesis; chemical reactions; nucleotide sequences; animal models;     Show all 13 Subjects
Abstract:
... Meat cooked at high temperatures contains mutagens and carcinogens known as heterocyclic amines (HCA). Cooking temperature and time determine the amount of HCA produced. The present study examined the DNA of liver, colon, and stomach from rats fed a high level of HCA for 27 weeks. Male Sprague-Dawley rats were fed a high-fat AIN-76A-based diet containing 60% by weight cooked beef containing a high ...
DOI:
10.1080/01635589809514668
PubMed:
9631495

3. Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats

Author:
Buijs, Nikki; Vermeulen, Mechteld A. R.; Weeda, Viola B.; Bading, James R.; Houdijk, Alexander P. J.; van Leeuwen, Paul A. M.
Source:
Nutrition and cancer 2015 v.67 no.5 pp. 713-720
ISSN:
1532-7914
Subject:
rats,   etc   ; arginine; cachexia; citrulline; diet; glutamine; immune system; intestines; kidneys; liver; metabolism; neoplasms; skeletal muscle;     Show all 13 Subjects
Abstract:
... Malignancies induce disposal of arginine, an important substrate for the immune system. To sustain immune function, the tumor-bearing host accelerates arginine's intestinal-renal axis by glutamine mobilization from skeletal muscle and this may promote cachexia. Glutamine supplementation stimulates argi-nine production in healthy subjects. Arginine's intestinal-renal axis and the effect of glutamin ...
DOI:
10.1080/01635581.2015.1029638

4. Adolescent Vitamin A Intake Alters Susceptibility to Mammary Carcinogenesis in the Sprague-Dawley Rat

Author:
Metz, Richard P.; Kaeck, Mark; Stacewicz-Sapuntzakis; Mitrenga, Terry; McCarty, Heidi; Schedin, Pepper
Source:
Nutrition and cancer 2002 v.42 no.1 pp. 78-90
ISSN:
0163-5581
Subject:
rats,   etc   ; adolescence; adolescents; carcinogenesis; dairy protein; early development; estradiol; glucocorticoid receptors; mammary glands; mammary neoplasms (animal); messenger RNA; nutrient intake; progesterone receptors; protein synthesis; retinyl palmitate; vitamin A; vitamin deficiencies;     Show all 17 Subjects
Abstract:
... We tested the hypothesis that adolescent dietary vitamin A intake impacts mammary gland development and subsequent sensitivity to carcinogenesis. Sprague-Dawley rats were fed a purified diet that was vitamin A deficient, adequate (2.2 mg retinyl palmitate/kg diet), or supranutritional (16 mg retinyl palmitate/kg diet) from 21 to 63 days of age, the period of adolescent mammary gland development. A ...
DOI:
10.1207/S15327914NC421_11
PubMed:
12235654

5. alpha-Tocopherol acetate supplementation enhances rat hepatic cytochrome PROD activity in the presence of phenobarbital induction

Author:
Lii, C.K.; Sung, W.C.; Ko, Y.J.; Chen, H.W.
Source:
Nutrition and cancer 1998 v.32 no.1 pp. 37-42
ISSN:
0163-5581
Subject:
rats,   etc   ; nutrient-drug interactions; liver; protein content; dose response; glutathione transferase; lipid peroxidation; phenobarbital; alpha-tocopherol; oxidoreductases; cytochrome P-450; animal models; vitamin supplements; vitamin deficiencies; blood plasma; enzyme activity;     Show all 16 Subjects
Abstract:
... Hepatic cytochrome P-450 enzymes play important roles in bioactivation of chemical carcinogens, biotransformation of many endogenous compounds, and detoxification of numerous xenobiotics. These enzyme activities have been shown to be regulated by various dietary factors. In our previous study, hepatic cytochrome pentoxyresorufin O-dealkylase (PROD) activity was decreased in rats fed an alpha-tocop ...
DOI:
10.1080/01635589809514714
PubMed:
9824855

6. alpha-Tocopherol suppresses mammary tumor sensitivity to anthracyclines in fish oil-fed rats

Author:
Colas, S.; Germain, E.; Arab, K.; Maheo, K.; Goupille, C.; Bougnoux, P.
Source:
Nutrition and cancer 2005 v.51 no.2 pp. 178-183
ISSN:
0163-5581
Subject:
rats,   etc   ; nutrient-drug interactions; drug therapy; nutritional intervention; malondialdehyde; redox reactions; mammary neoplasms (animal); alpha-tocopherol; animal models; fish oils; antioxidant activity; sardines; omega-3 fatty acids; antioxidants; anticarcinogenic activity;     Show all 15 Subjects
Abstract:
... Polyunsaturated fatty acids (PUFAs) have been reported to enhance the efficacy of chemotherapeutic agents that produce reactive oxygen species such as anthracyclines. We previously reported in a human breast cancer cell line that the increased cytotoxic activity of anthracyclines by several PUFAs was abolished by antioxidants and enhanced by pro-oxidants, suggesting that lipid peroxidation was inv ...
DOI:
10.1207/s15327914nc5102_8
PubMed:
15860440

7. Alterations in postprandial glycogen and lipid synthesis in cachectic tumor-bearing rats

Author:
Emery, P.W.; Carpenter, T.T.A.; Obeid, O.A.
Source:
Nutrition and cancer 1993 v.20 no.3 pp. 231-240
ISSN:
0163-5581
Subject:
rats,   etc   ; restricted feeding; biosynthesis; glycogen; lipids; ad libitum feeding;     Show all 6 Subjects
Abstract:
... Alterations in the postprandial metabolism of glucose were investigated in groups of tumor-bearing rats and freely fed controls and in groups of normal rats whose food intake had been restricted to match that of the tumor-bearing rats. A standard mixed meal was administered by gavage, and the rate of incorporation of 3H from 3H2O into hepatic glycogen and into saponifiable lipids in the liver and ...
DOI:
10.1080/01635589309514291
PubMed:
8108273

8. Amount and type of dietary lipid modulate rat hepatic cytochrome P-450 activity

Author:
Chen, H.W.; Lii, C.K.; Wu, M.H.; Ou, C.C.; Sheen, L.Y.
Source:
Nutrition and cancer 1997 v.29 no.2 pp. 174-180
ISSN:
0163-5581
Subject:
rats,   etc   ; dietary fat; nutrient intake; liver; cytochrome P-450; enzyme activity; dose response; tallow; olive oil; corn oil; linseed oil; menhaden oil; animal models; experimental diets; phospholipids; fatty acids; food intake; body weight; weight gain; weight; acetone; phenobarbital; nutrient-drug interactions; microsomes; cytosol; protein content; glutathione transferase; lyases; oxidoreductases; dietary supplements; salinity; water quality; saline water;     Show all 33 Subjects
Abstract:
... The influence of the amount and type of dietary lipid on rat hepatic cytochrome P-450 activities in the presence and absence of inducer administration was investigated. Weanling male Sprague-Dawley rats were fed fat-free or 20% beef tallow, olive oil, corn oil, linseed oil, or menhaden oil diets in combination with one of the following three treatments: no inducer, intraperitoneal injection of phe ...
DOI:
10.1080/01635589709514621
PubMed:
9427983

9. An increase in vitamin A status by the feeding of conjugated linoleic acid

Author:
Banni, S.; Angioni, E.; Casu, V.; Melis, M.P.; Scrugli, S.; Carta, G.; Corongiu, P.; Ip, C.
Source:
Nutrition and cancer 1999 v.33 no.1 pp. 53-57
ISSN:
0163-5581
Subject:
rats,   etc   ; linoleic acid; liver; nutritional status; vitamin content; animal models; dietary supplements; vitamin A;     Show all 8 Subjects
Abstract:
... Previous research indicated that conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. The present study showed a progressive increase in retinol (vitamin A alcohol) in the liver in proportion to CLA intake in rats that were fed different levels of CLA (in increments of 0.5%) for 1 month. The escalation reached a magnitude of about fivefold over the control at 2% dietary ...
DOI:
10.1080/01635589909514748
PubMed:
10227044

10. Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats

Author:
Lala, G.; Malik, M.; Zhao, C.; He, J.; Kwon, Y.; Giusti, M.M.; Magnuson, B.A.
Source:
Nutrition and cancer 2006 v.54 no.1 pp. 84-93
ISSN:
0163-5581
Subject:
rats,   etc   ; Prunus virginiana; DNA damage; urine; grapes; nutrition-genotype interaction; chemoprevention; oxidative stress; biomarkers; feces; Vaccinium myrtillus; Vitis vinifera; animal disease models; blood serum; colorectal neoplasms; cell proliferation; diet; cyanin; nutrient availability; bilberries; plant-based foods; prostaglandin synthase; bile acids; anticarcinogenic activity;     Show all 24 Subjects
Abstract:
... The aim of the present study was to investigate the chemoprotective activity of anthocyanin-rich extracts (AREs) from bilberry (Vaccinium myrtillus L.), chokeberry (Aronia meloncarpa E.), and grape (Vitis vinifera) by assessing multiple biomarkers of colon cancer in male rats treated with a colon carcinogen, azoxymethane. Fischer 344 male rats were fed the AIN-93 diet (control) or AIN-93 diet supp ...
DOI:
10.1207/s15327914nc5401_10
PubMed:
16800776

11. Antibiotic Suppression of Intestinal Microbiota Reduces Heme-Induced Lipoperoxidation Associated with Colon Carcinogenesis in Rats

Author:
Martin, O. C. B.; Lin, C.; Naud, N.; Tache, S.; Raymond-Letron, I.; Corpet, D. E.; Pierre, F. H.
Source:
Nutrition and cancer 2015 v.67 no.1 pp. 119-125
ISSN:
1532-7914
Subject:
rats,   etc   ; agar; antibiotics; bacteria; biomarkers; carcinogenesis; colon; colorectal neoplasms; diet; epidemiological studies; heme; heme iron; hemoglobin; intestinal microorganisms; peroxidation; red meat; risk; thiobarbituric acid;     Show all 18 Subjects
Abstract:
... Epidemiological studies show that heme iron from red meat is associated with increased colorectal cancer risk. In carcinogen-induced-rats, a heme iron-rich diet increases the number of precancerous lesions and raises associated fecal biomarkers. Heme-induced lipoperoxidation measured by fecal thiobarbituric acid reagents (TBARs) could explain the promotion of colon carcinogenesis by heme. Using a ...
DOI:
10.1080/01635581.2015.976317

12. Anticarcinogenic Effects of Dried Citrus Peel in Colon Carcinogenesis Due to Inhibition of Oxidative Stress

Author:
Onuma, Wakana; Asai, Daichi; Tomono, Susumu; Miyamoto, Shingo; Fujii, Gen; Hamoya, Takahiro; Nagano, Aya; Takahashi, Satoru; Masumori, Shoji; Miyoshi, Noriyuki; Wakabayashi, Keiji; Mutoh, Michihiro
Source:
Nutrition and cancer 2017 v.69 no.6 pp. 855-861
ISSN:
1532-7914
Subject:
rats,   etc   ; Citrus; anticarcinogenic activity; blood serum; carcinogenesis; citrus peels; colon; colorectal neoplasms; death; diet; humans; luciferase; oxidative stress; reactive oxygen species; reporter genes; transcription (genetics); transcription factor NF-kappa B;     Show all 17 Subjects
Abstract:
... Colorectal cancer is one of the leading causes of death worldwide. Reactive oxygen species produce oxidative stress and contribute to colorectal carcinogenesis. Because dietary citrus has been shown to reduce oxidative stress, we investigated the effects of citrus peel extract at dilutions of 1/200–1/500 on the activity of oxidative-stress-related transcription factors, including AP-1, NF-κB, NRF2 ...
DOI:
10.1080/01635581.2017.1339096

13. Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats

Author:
Punvittayagul, Charatda; Sankam, Paweena; Taya, Sirinya; Wongpoomchai, Rawiwan
Source:
Nutrition and cancer 2016 v.68 no.4 pp. 646-653
ISSN:
1532-7914
Subject:
rats,   etc   ; Oryza sativa; Salmonella; acute toxicity; body weight; carcinogenicity; chemoprevention; diethylnitrosamine; glutathione; hepatocytes; liver; methanol; mutation; oral administration; rice; Thailand;     Show all 16 Subjects
Abstract:
... Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present study was designed to evaluate its in vivo anticlastogenic and anticarcinogenic potentials. The purple rice extract had no acute toxicity on ...
DOI:
10.1080/01635581.2016.1158289

14. Antimetastatic Effects and Mechanisms of Apo-8′-Lycopenal, an Enzymatic Metabolite of Lycopene, Against Human Hepatocarcinoma SK-Hep-1 Cells

Author:
Yang, Chih-Min; Hu, Te-Yu; Hu, Miao-Lin
Source:
Nutrition and cancer 2012 v.64 no.2 pp. 274-285
ISSN:
1532-7914
Subject:
rats,   etc   ; guanosinetriphosphatase; hepatoma; humans; liver; lycopene; metabolites; non-specific protein-tyrosine kinase; protein synthesis; signal transduction;     Show all 10 Subjects
Abstract:
... Lycopene is primarily metabolized by carotenoid monoxygenase II into apo-8′- and apo-12′-lycopenal in the rat liver. Although lycopene possesses antimetastatic activity in a highly invasive hepatoma SK-Hep-1 cell line, little is known whether its metabolites have a similar effect. In this study, we investigated the antimetastatic effects of apo-8′-lycopenal (1–10 μM) in comparison with lycopene (1 ...
DOI:
10.1080/01635581.2012.643273
PubMed:
22211877

15. Antimutagenic and Anticancer Effects of Lactic Acid Bacteria Isolated From Tarhana Through Ames Test and Phylogenetic Analysis By 16S rDNA

Author:
Abbas Ahmadi, Maryam; Tajabadi Ebrahimi, Maryam; Mehrabian, Sedigheh; Tafvizi, Farzaneh; Bahrami, Hoda; Dameshghian, Mahsa
Source:
Nutrition and cancer 2014 v.66 no.8 pp. 1406-1413
ISSN:
1532-7914
Subject:
rats,   etc   ; Ames test; Lactobacillus brevis; Lactobacillus casei; Lactobacillus plantarum; anticarcinogenic activity; antimutagenic activity; cell suspension culture; lactic acid bacteria; molecular biology; nucleotide sequences; nutrition; phylogeny; probiotics; ribosomal DNA; sodium azide;     Show all 16 Subjects
Abstract:
... Deaths due to cancer have been increasing in many countries in recent years. One of the beneficial probiotic properties is potential of antimutagenic and anticancer effects. The aim of this study was to investigate antimutagenic and anticancer effects of 25 strains of lactobacilli spp isolated from Tarhana in vitro conditions and to identify selected strains based on molecular biology. Antimutagen ...
DOI:
10.1080/01635581.2014.956254

16. Antineoplastic Activity of Solidago virgaurea on Prostatic Tumor Cells in an SCID Mouse Model

Author:
Gross, Steven C.; Goodarzi, Goodarz; Watabe, Misako; Bandyopadhyay, Sucharita; Pai, Sudha K.; Watabe, Kounosuke
Source:
Nutrition and cancer 2002 v.43 no.1 pp. 76-81
ISSN:
0163-5581
Subject:
rats,   etc   ; Solidago virgaurea; adverse effects; animal models; anticarcinogenic activity; cytotoxicity; herbal medicines; humans; leaves; lung neoplasms; medicine; melanoma; mice; molecular weight; screening; severe combined immunodeficiency;     Show all 16 Subjects
Abstract:
... Solidago virgaurea (goldenrod) has traditionally been used as an anti-inflammatory herbal medicine for the treatment of various symptoms, including prostatic diseases. The plant has also been reported to have antibacterial, spasmolytic, and carminative properties. During the course of our screening for antineoplastic activities in various herbal plants, we found that the extract of S. virgaurea ex ...
DOI:
10.1207/S15327914NC431_9
PubMed:
12467138

17. Antioxidant, antimutagenic, and antitumor effects of pine needles (Pinus densiflora)

Author:
Kwak, C.S.; Moon, S.C.; Lee, M.S.
Source:
Nutrition and cancer 2006 v.56 no.2 pp. 162-171
ISSN:
0163-5581
Subject:
rats,   etc   ; antimutagenic activity; disease prevention; Salmonella Typhimurium; mammary neoplasms (animal); medicinal plants; plant extracts; traditional foods; dietary supplements; sarcoma; animal disease models; bioassays; mice; Pinus densiflora; antioxidant activity; ethanol; supercritical fluid extraction; free radicals; conifer needles; free radical scavengers; Oriental traditional medicine; anticarcinogenic activity;     Show all 22 Subjects
Abstract:
... Pine needles (Pinus densiflora Siebold et Zuccarini) have long been used as a traditional health-promoting medicinal food in Korea. To investigate their potential anticancer effects, antioxidant, antimutagenic, and antitumor activities were assessed in vitro and/or in vivo. Pine needle ethanol extract (PNE) significantly inhibited Fe(2+)-induced lipid peroxidation and scavenged 1,1-diphenyl-2-picr ...
DOI:
10.1207/s15327914nc5602_7
PubMed:
17474862

18. Antioxidants Delay Clinical Signs and Systemic Effects of ENU Induced Brain Tumors in Rats

Author:
Hervouet, E.; Staehlin, O.; Pouliquen, D.; Debien, E.; Cartron, P-F.; Menanteau, J.; Vallette, F. M.; Olivier, C.
Source:
Nutrition and cancer 2013 v.65 no.5 pp. 686-694
ISSN:
1532-7914
Subject:
rats,   etc   ; alpha-tocopherol; animal models; antioxidant activity; antioxidants; ascorbic acid; beta-carotene; binding proteins; brain; diet; gene expression; growth retardation; humans; in vivo studies; insulin; messenger RNA; neoplasms; phytochemicals; platelet-derived growth factor; sodium selenite; superoxide dismutase; zinc;     Show all 22 Subjects
Abstract:
... According to our previous study suggesting that antioxidant properties of phytochemicals in the diet decrease glioma aggressiveness, we used a SUVIMAX-like diet (“Supplementation en VItamines et Minéraux AntioXydants”) (enriched with alpha-tocopherol, beta carotene, vitamin C, zinc, and sodium selenite), adapted to rats. The present results showed that each of the antioxidants inhibited growth of ...
DOI:
10.1080/01635581.2013.789541
PubMed:
23859036

19. Antioxidative and Apoptotic Properties of Polyphenolic Extracts from Edible Part of Artichoke (Cynara scolymus L.) on Cultured Rat Hepatocytes and on Human Hepatoma Cells

Author:
Miccadei, S.; Di Venere, D.; Cardinali, A.; Romano, F.; Durazzo, A.; Foddai, M.S.; Fraioli, R.; Mobarhan, S.; Maiani, G.
Source:
Nutrition and cancer 2008 v.60 no.2 pp. 276-283
ISSN:
0163-5581
Subject:
rats,   etc   ; polyphenols; hepatoma; lipid peroxidation; oxidative stress; glutathione; artichokes; malondialdehyde; Cynara cardunculus; synergism; apoptosis; hepatoprotective effect; human cell lines; cell culture; antioxidant activity; hepatocytes; viability; vegetable extracts; free radicals; free radical scavengers; animal models; plant-based foods;     Show all 22 Subjects
Abstract:
... Cultured rat hepatocytes and human hepatoma HepG2 cells were used to evaluate the hepatoprotective properties of polyphenolic extracts from the edible part of artichoke (AE). The hepatocytes were exposed to H2O2generated in situ by glucose oxidase and were treated with either AE, or pure chlorogenic acid (ChA) or with the well known antioxidant, N, N'-diphenyl-p-phenilenediamine (DPPD). Addition o ...
DOI:
10.1080/01635580801891583

20. Antiproliferative Effect of Vine Stem Extract from Spatholobus Suberectus Dunn on Rat C6 Glioma Cells Through Regulation of ROS, Mitochondrial Depolarization, and P21 Protein Expression

Author:
Kim, Hyungkuen; Yi, Sun Shin; Lee, Hak-Kyo; Heo, Tae-Hwe; Park, Sang-Kyu; Jun, Hyun Sik; Song, Ki Duk; Kim, Sung-Jo
Source:
Nutrition and cancer 2018 v.70 no.4 pp. 605-619
ISSN:
1532-7914
Subject:
rats,   etc   ; Spatholobus; Western blotting; antineoplastic activity; antioxidant activity; bioactive compounds; cell cycle checkpoints; gene expression; herbal medicines; messenger RNA; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; viability; vines; China;     Show all 20 Subjects
Abstract:
... The vine stem of Spatholobus suberectus Dunn (SS) is used as a traditional herbal medicine in China. Chinese herbal medicines are well known as natural bioactive compounds that can be used as new medicines, and their antioxidant and anticancer effects have also been reported. This study aimed to examine the anticancer effect of a high-pressure hot-water SS extract on rat C6 glioma cells. The SS ex ...
DOI:
10.1080/01635581.2018.1460673