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- Banez, Melissa J.; Geluz, Matthew I.; Chandra, Anjali; Hamdan, Tesnim; Biswas, Olivia S.; Bryan, Nathan S.; Von Schwarz, Ernst R.
- Nutrition research 2020 v.78 pp. 11-26
- animal models; anti-inflammatory activity; antioxidants; blood flow; blood pressure; calcium; cardioprotective effect; cardiovascular diseases; clinical trials; curcumin; cytokines; dietary supplements; fish oils; glucose; human health; humans; inflammation; markets; mechanism of action; metabolism; morbidity; mortality; nitric oxide; nutrients; nutritional intervention; oxidative stress; patients; polyphenols; resveratrol; risk factors; risk reduction; transcription factors
- ... The potential benefits of supplemental nutrients and dietary interventions against cardiovascular morbidity and mortality have been extensively investigated throughout the years. Numerous supplements claim cardioprotection and reduction of cardiovascular risk factors, but the roles of many supplements have not been determined. In the vast number of supplements on the market asserting cardioprotect ...
- Saxena, Abhinav R; Ilic, Zoran; Sripada, Veda; Crawford, Dana R.
- Nutrition research 2020 v.78 pp. 93-104
- breast neoplasms; cell growth; curcumin; drugs; fruit extracts; human diseases; metastasis; neoplasm cells; quercetin
- ... Her2-dependent breast cancer is treated with pharmacological drugs (eg, Herceptin, lapatinib) that target Her2 signaling. Curcumin has emerged as a potential co-treatment for this and other cancers, but prior studies have focused on non-attainable concentrations. Here we test the hypothesis that attainable in vivo levels of dietary curcumin can reduce Her2 signaling. Consistent with previous studi ...