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- Fujii, Tatiane Mieko de Meneses; Norde, Marina Maintinguer; Fisberg, Regina Mara; Marchioni, Dirce Maria Lobo; Ordovás, José M.; Rogero, Marcelo Macedo
- Nutrition research 2020 v.78 pp. 42-49
- adults; alleles; enzyme activity; fatty acid composition; genetic factors; genotype; health surveys; high density lipoprotein cholesterol; linoleic acid; linolenic acid; lipid metabolism; long chain polyunsaturated fatty acids; low density lipoprotein cholesterol; men; oleic acid; phenotype; regression analysis; single nucleotide polymorphism; stearoyl-CoA desaturase; women; Brazil
- ... Cardiometabolic risk involves environmental and genetic factors. We aimed to investigate the relationship between plasma fatty acids and single nucleotide polymorphisms (SNPs), located in elongase and desaturases genes, and cardiometabolic parameters in a cross-sectional population-based survey. A sample of 226 adults who participated in the Health Survey of Sao Paulo, Brazil, was selected. Clinic ...
- Zhu, Chenghao; Sawrey-Kubicek, Lisa; Bardagjy, Allison S.; Houts, Hannah; Tang, Xinyu; Sacchi, Romina; Randolph, Jody M.; Steinberg, Francene M.; Zivkovic, Angela M.
- Nutrition research 2020 v.78 pp. 36-41
- betaine; blood; breakfast; cardiovascular diseases; carnitine; choline; cross-over studies; eggs; fasting; hypercholesterolemia; intestinal microorganisms; intestines; lipid metabolism; liver; metabolites; overweight; postmenopause; risk; trimethylamine; women
- ... As a crucial part of the symbiotic system, the gut microbiome is metabolically connected to many diseases and conditions, including cardiovascular diseases (CVD). Trimethylamine (TMA) is produced by gut bacteria from dietary choline, betaine, or L-carnitine, and is then converted in the liver to Trimethylamine N-oxide (TMAO), which in turn affects hepatic and intestinal lipid metabolism. Circulati ...