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- Dahl, Wendy J.; Hung, Wei-Lun; Ford, Amanda L.; Suh, Joon Hyuk; Auger, Jerémié; Nagulesapillai, Varuni; Wang, Yu
- Nutrition research 2020 v.78 pp. 72-81
- bioavailability; blood serum; cardiovascular diseases; carnitine; dementia; excretion; fermentation; food intake; genes; high protein diet; intestinal microorganisms; liquid chromatography; metabolites; prebiotics; probiotics; proteolysis; red meat; ribosomal RNA; risk; sequence analysis; sulfates; tandem mass spectrometry; trimethylamine; women
- ... Diets including red meat and other animal-sourced foods may increase proteolytic fermentation and microbial-generated trimethylamine (TMA) and, subsequently, trimethylamine-N-oxide (TMAO), a metabolite associated with increased risk of cardiovascular disease and dementia. It was hypothesized that compared to usual dietary intake, a maintenance-energy high-protein diet (HPD) would increase products ...
- Zhu, Chenghao; Sawrey-Kubicek, Lisa; Bardagjy, Allison S.; Houts, Hannah; Tang, Xinyu; Sacchi, Romina; Randolph, Jody M.; Steinberg, Francene M.; Zivkovic, Angela M.
- Nutrition research 2020 v.78 pp. 36-41
- betaine; blood; breakfast; cardiovascular diseases; carnitine; choline; cross-over studies; eggs; fasting; hypercholesterolemia; intestinal microorganisms; intestines; lipid metabolism; liver; metabolites; overweight; postmenopause; risk; trimethylamine; women
- ... As a crucial part of the symbiotic system, the gut microbiome is metabolically connected to many diseases and conditions, including cardiovascular diseases (CVD). Trimethylamine (TMA) is produced by gut bacteria from dietary choline, betaine, or L-carnitine, and is then converted in the liver to Trimethylamine N-oxide (TMAO), which in turn affects hepatic and intestinal lipid metabolism. Circulati ...