Jump to Main Content
- Shi, Lei, et al. Show all 5 Authors
- Organic letters 2018 v.20 no.20 pp. 6415-6419
- chemical structure; diastereoselectivity; enantioselectivity; hydrogen; hydrogenation; organic compounds; tautomerization
- ... An efficient iridium-catalyzed hydrogenation of 4,6-disubstituted 2-hydroxypyrimidines has been achieved, giving chiral cyclic ureas with excellent diastereoselectivities and up to 96% ee of enantioselectivities. In the presence of the in situ generated hydrogen halide, the equilibrium of the lactame–lactime tautomerism of 2-hydroxypyrimidine is more toward the oxo form with lower aromaticity, whi ...