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1. Direct Oxidative Cleavage of Multiple Csp3–H Bonds and a C–C Bond in 2-(Pyridin-2-yl)acetate Derivatives: Formal [3 + 1 + 1] Synthesis of 3-(Pyridin-2-yl)indolizine Skeletons

Author:
Zhao, Peng,   et al.   ; Wu, Xia; Geng, Xiao; Zhang, Jingjing; Gong, Xingxing; Wu, Yan-dong; Wu, An-xin;     Show all 7 Authors
Source:
Organic letters 2017 v.19 no.12 pp. 3319-3322
ISSN:
1523-7052
Subject:
chemical bonding; chemical reactions; chemical structure; indolizines; ketones; pyridines
Abstract:
... A novel iodine-promoted oxidative cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and methyl ketones via the cleavage of multiple Cₛₚ₃–H bonds has been developed, which also achieved efficient cleavage of a C–C bond in the 2-(pyridin-2-yl)acetate derivatives. This protocol represents an elegant molecular fragment assembly of diverse 3-(pyridin-2-yl)indolizines via a formal [3 + 1 ...
DOI:
10.1021/acs.orglett.7b01492