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- Miller, Michael W., et al. Show all 4 Authors
- Organic letters 2013 v.15 no.11 pp. 2830-2833
- antagonists; arylation; chemical structure; glucagon receptors; methodology; organic compounds
- ... A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program. ...