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- ARRUDA-COSTA, N.; ESCRIVANI, D.; ALMEIDA-AMARAL, E. E.; MEYER-FERNANDES, J. R.; ROSSI-BERGMANN, B.
- Parasitology 2017 v.144 no.10 pp. 1375-1383
- Leishmania amazonensis; amastigotes; cutaneous leishmaniasis; enzyme activity; enzyme inhibition; enzyme inhibitors; enzymes; furosemide; inhibitory concentration 50; macrophages; mice; nitric oxide; oral administration; pH; parasites; promastigotes; reactive oxygen species; therapeutics
- ... Leishmania amazonensis promastigotes are known to express furosemide (Lasix®)-sensitive P-type membrane Na⁺-ATPase. In the present study, furosemide activity was studied in intracellular amastigotes and infected BALB/c mice to investigate its efficacy in cutaneous leishmaniasis (CL). Intracellular parasites, but not macrophages, were found to be sensitive to killing by furosemide (IC₅₀ = 87 µ m vs ...
- KUMARI, P.; NIGAM, R.; SINGH, A.; NAKADE, U. P.; SHARMA, A.; GARG, S. K.; SINGH, S. K.
- Parasitology 2017 v.144 no.10 pp. 1412-1416
- Demodex canis; cholinesterase; demodicosis; dogs; enzyme activity; immunosuppression; interleukin-10; mites; pathogenesis; tumor necrosis factor-alpha; veterinary medicine
- ... Demodex canis infestation in dogs remains one of the main challenges in veterinary dermatology. The exact pathogenesis of canine demodicosis is unknown but an aberration in immune status is considered very significant. No studies have underpinned the nexus between induction of demodicosis and neural immunosuppressive pathways so far. We have evaluated the involvement of cholinergic pathways in ass ...