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- SÁNCHEZ-MORENO, MANUEL, et al. Show all 10 Authors
- Parasitology 2017 v.144 no.9 pp. 1133-1143
- Chagas disease; Leishmania braziliensis; Leishmania infantum; Trypanosoma cruzi; acute toxicity; amastigotes; animal models; antiprotozoal properties; benznidazole; cytotoxicity; drugs; in vitro studies; in vivo studies; iron; macrophages; mice; parasites; salts; sodium; superoxide dismutase
- ... The synthesis and antiprotozoal activity of some simple dialkyl pyrazole-3,5-dicarboxylates (compounds 2–6) and their sodium salts (pyrazolates) (compounds 7–9) against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis are reported. In most cases the studied compounds showed, especially against the clinically significant amastigote forms, in vitro activities higher than those of t ...
- SÁNCHEZ-MORENO, MANUEL, et al. Show all 11 Authors
- Parasitology 2017 v.144 no.13 pp. 1783-1790
- Leishmania braziliensis; Leishmania donovani; Leishmania infantum; Trypanosoma cruzi; antileishmanial properties; aromatic amines; drug therapy; enzyme inhibition; glucose; humans; iron; leishmaniasis; mechanism of action; metabolism; parasites; pathogenicity; superoxide dismutase; vaccines
- ... Leishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs. Therefore, research aiming at the development of new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, we present 20 arylaminoketone deriva ...