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1. Study on the mitochondrial apoptosis pathways of small cell lung cancer H446 cells induced by Trichinella spiralis muscle larvae ESPs

Author:
LUO, JINGMEI; YU, LI; XIE, GUANGCHENG; LI, DAN; SU, MENG; ZHAO, XUERONG; DU, LUANYING
Source:
Parasitology 2017 v.144 no.6 pp. 793-800
ISSN:
1469-8161
Subject:
excretory-secretory products,   etc   ; Trichinella spiralis; Western blotting; apoptosis; caspase-3; caspase-9; cell proliferation; coculture; flow cytometry; genes; lung neoplasms; mitochondria; muscle larvae; neoplasm cells; reverse transcriptase polymerase chain reaction;     Show all 15 Subjects
Abstract:
... Trichinella spiralis (T.spiralis) muscle-larva (ML) excretory–secretory proteins (ESPs) contain antitumour-active substances. ESPs have been shown to inhibit tumour growth. To explore the effects of these proteins on small cell lung cancer cells and the possible mechanisms of their antineoplastic action, H446 SCLC cells were co-cultured with different concentrations of T. spiralis ML ESPs for 12, ...
DOI:
10.1017/S0031182016002535
PubMed:
28073393

2. Major acid endopeptidases of the blood-feeding monogenean Eudiplozoon nipponicum (Heteronchoinea: Diplozoidae)

Author:
JEDLIČKOVÁ, LUCIE; DVOŘÁKOVÁ, HANA; KAŠNÝ, MARTIN; ILGOVÁ, JANA; POTĚŠIL, DAVID; ZDRÁHAL, ZBYNĚK; MIKEŠ, LIBOR
Source:
Parasitology 2016 v.143 no.4 pp. 494-506
ISSN:
1469-8161
Subject:
excretory-secretory products,   etc   ; Cyprinus carpio; Trematoda; cathepsin D; cathepsin L; complementary DNA; cysteine; digestion; genes; hemoglobin; immune system; mass spectrometry; parasites; peptides; proteomics; translation (genetics);     Show all 16 Subjects
Abstract:
... In parasitic flatworms, acid endopeptidases are involved in crucial processes, including digestion, invasion, interactions with the host immune system, etc. In haematophagous monogeneans, however, no solid information has been available about the occurrence of these enzymes. Here we aimed to identify major cysteine and aspartic endopeptidase activities in Eudiplozoon nipponicum, an invasive haemat ...
DOI:
10.1017/S0031182015001808
PubMed:
26888494

3. What helminth genomes have taught us about parasite evolution

Author:
ZAROWIECKI, MAGDALENA; BERRIMAN, MATT; Jackson, Andrew P.
Source:
Parasitology 2015 v.142 no.S1 pp. S85
ISSN:
1469-8161
Subject:
excretory-secretory products,   etc   ; Nematoda; Platyhelminthes; antigenic variation; biogenesis; evolution; genes; helminths; immune system; meta-analysis; metabolism; proteinases; vitamins;     Show all 13 Subjects
Abstract:
... The genomes of more than 20 helminths have now been sequenced. Here we perform a meta-analysis of all sequenced genomes of nematodes and Platyhelminthes, and attempt to address the question of what are the defining characteristics of helminth genomes. We find that parasitic worms lack systems for surface antigenic variation, instead maintaining infections using their surfaces as the first line of ...
DOI:
10.1017/S0031182014001449
PubMed:
25482650
PubMed Central:
PMC4413821

4. Characterization of genes with a putative key role in the parasitic lifestyle of the nematode Strongyloides ratti

Author:
SPINNER, W. G.; THOMPSON, F. J.; EMERY, D. C.; VINEY, M. E.
Source:
Parasitology 2012 v.139 no.10 pp. 1317-1328
ISSN:
1469-8161
Subject:
excretory-secretory products,   etc   ; parasitism; Strongyloides; humans; microarray technology; recombinant proteins; vaccines; models; expressed sequence tags; reverse transcriptase polymerase chain reaction; Western blotting; gastrointestinal nematodes; gene expression; pathogens; rats; people; adults;     Show all 17 Subjects
Abstract:
... Parasitic nematodes are significant pathogens of humans and other animals. The molecular and genetic basis of animal parasitism is not yet fully understood. Strongyloides spp. are a genus of gastrointestinal nematodes of which species infect approximately 100–200 million people worldwide. S. ratti is a natural parasite of the rat, and a useful and amenable laboratory model. Previous EST and ...
DOI:
10.1017/S0031182012000637
PubMed:
22717055

5. Characterization of hydrophobic-ligand-binding proteins of Taenia solium that are expressed specifically in the adult stage

Author:
RAHMAN, M.; LEE, E.-G.; KIM, S.-H.; BAE, Y.-A.; WANG, H.; YANG, Y.; KONG, Y.
Source:
Parasitology 2012 v.139 no.10 pp. 1361-1374
ISSN:
1469-8161
Subject:
excretory-secretory products,   etc   ; hydrophobicity; cysticercosis; palmitic acid; oleic acid; adults; polypeptides; proteome; open reading frames; recombinant proteins; amino acids; uptake mechanisms; screening; sequence analysis; complementary DNA; hosts; cDNA libraries; Taenia solium; Moniezia expansa; expressed sequence tags; Hymenolepis diminuta; mining;     Show all 22 Subjects
Abstract:
... Taenia solium, a causative agent of taeniasis and cysticercosis, has evolved a repertoire of lipid uptake mechanisms. Proteome analysis of T. solium excretory-secretory products (TsESP) identified 10 kDa proteins displaying significant sequence identity with cestode hydrophobic-ligand-binding-proteins (HLBPs). Two distinct 362- and 352-bp-long cDNAs encoding 264- and 258-bp-long open reading frame ...
DOI:
10.1017/S0031182012000613
PubMed:
22657393

6. Identification and characterization of a novel specific secreted protein family for selected members of the subfamily Ostertagiinae (Nematoda)

Author:
Saverwyns, H.; Visser, A.; Nisbet, A.J.; Peelaers, I.; Gevaert, K.; Vercruysse, J.; Claerbout, E.; Geldhof, P.
Source:
Parasitology 2008 v.135 no.1 pp. 63-70
ISSN:
0031-1820
Subject:
excretory-secretory products,   etc   ; Ostertagia ostertagi; developmental stages; phylogeny; gastrointestinal nematodes; gene expression; transcription (genetics); signal peptide; Teladorsagia circumcincta; sequence homology;     Show all 10 Subjects
DOI:
10.1017/S0031182007003666

7. A preliminary proteomic survey of the in vitro excretory/secretory products of fourth-stage larval and adult Teladorsagia circumcincta

Author:
Craig, H.; Wastling, J.M.; Knox, D.P.
Source:
Parasitology 2006 v.132 no.4 pp. 535-543
ISSN:
0031-1820
Subject:
excretory-secretory products,   etc   ; amino acid sequences; gastrointestinal nematodes; mass spectrometry; nematode larvae; in vitro studies; Teladorsagia circumcincta; proteomics; protein composition;     Show all 9 Subjects
DOI:
10.1017/S0031182005009510

8. Molecular cloning and characterization of an Rcd1-like protein in excretory-secretory products of Trichinella pseudospiralis

Author:
Nagano, I.; Wu, Z.; Takahashi, Y.
Source:
Parasitology 2006 v.133 no.6 pp. 785-792
ISSN:
0031-1820
Subject:
excretory-secretory products,   etc   ; Trichinella pseudospiralis; complementary DNA; muscle larvae; recombinant proteins; amino acid sequences; gene expression; nucleotide sequences; antigen-antibody reactions; sequence homology; immunocytochemistry;     Show all 11 Subjects
DOI:
10.1017/S0031182006001107