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- Řežábková, Lucie; Brabec, Jan; Jirků, Milan; Dellerba, Marc; Kuchta, Roman; Modrý, David; Parker, William; Jirků Pomajbíková, Kateřina
- Parasitology international 2019 v.71 pp. 121-125
- Hymenolepis diminuta; cryptic species; genes; genetic variation; humans; rats; tapeworms; therapeutics; Europe; United States
- ... The cestode Hymenolepis diminuta is highly prevalent in wild rat populations and has also been observed rarely in humans, generally causing no apparent harm. The organism has been studied for decades in the laboratory, and its colonization of laboratory rats has recently been shown as protective against some inflammation-associated disorders. Recently, H. diminuta has become a leading candidate fo ...
- Nyariki, James N.; Ochola, Lucy A.; Jillani, Ngalla E.; Nyamweya, Nemwel O.; Amwayi, Peris E.; Yole, Dorcas S.; Azonvide, Laurent; Isaac, Alfred Orina
- Parasitology international 2019 v.71 pp. 106-120
- Plasmodium berghei; angiopoietin-1; angiopoietin-2; animal models; antioxidants; brain; cerebral malaria; chemokine CCL4; cholesterol; clinical trials; coenzyme Q10; edema; gene expression; glutathione; inflammation; malondialdehyde; mice; neuropathology; oral administration; oxidative stress; phosphorylation; therapeutics; transcription factor NF-kappa B; triacylglycerols; tumor necrosis factor-alpha
- ... In animal model of experimental cerebral malaria (ECM), the genesis of neuropathology is associated with oxidative stress and inflammatory mediators. There is limited progress in the development of new approaches to the treatment of cerebral malaria. Here, we tested whether oral supplementation of Coenzyme Q10 (CoQ10) would offer protection against oxidative stress and brain associated inflammatio ...