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You searched for: Author yoshiaki Remove constraint Author: yoshiaki Journal Parasitology international Remove constraint Journal: Parasitology international Publication Year 2012 Remove constraint Publication Year: 2012 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK)

Author:
Kitamura, Yoshiaki,   et al.   ; Kato, Aya; Yasuda, Yuri; Kandeel, Mahmoud; Kitade, Yukio;     Show all 5 Authors
Source:
Parasitology international 2012 v.61 no.3 pp. 501-503
ISSN:
1383-5769
Subject:
Plasmodium falciparum; antimalarials; drugs; enzyme inhibition; humans; parasitology; pyrimidine nucleotides; structure-activity relationships; substrate specificity; thymidine
Abstract:
... During the course of our research into new anti-malaria drugs, Plasmodium falciparum thymidylate kinase (PfTMK) has emerged as an important drug target because of its unique substrate specificity. Compared with human thymidylate kinase (HsTMK), PfTMK shows broader substrate specificity, which includes both purine and pyrimidine nucleotides. PfTMK accepts both 2′-deoxyguanosine monophosphate (dGMP) ...
DOI:
10.1016/j.parint.2012.03.001