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- Kitamura, Yoshiaki, et al. Show all 5 Authors
- Parasitology international 2012 v.61 no.3 pp. 501-503
- Plasmodium falciparum; antimalarials; drugs; enzyme inhibition; humans; parasitology; pyrimidine nucleotides; structure-activity relationships; substrate specificity; thymidine
- ... During the course of our research into new anti-malaria drugs, Plasmodium falciparum thymidylate kinase (PfTMK) has emerged as an important drug target because of its unique substrate specificity. Compared with human thymidylate kinase (HsTMK), PfTMK shows broader substrate specificity, which includes both purine and pyrimidine nucleotides. PfTMK accepts both 2′-deoxyguanosine monophosphate (dGMP) ...