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1. Leishmania tropica: suggestive evidences for the effect of infectious dose on pathogenicity and immunogenicity in an experimental model

Author:
Rostamian, Mosayeb; Jafari, Davood; Abolghazi, Maryam; Farahani, Hadiseh; Niknam, Hamid M.
Source:
Parasitology research 2018 v.117 no.9 pp. 2949-2956
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Leishmania tropica; ears; humans; immune response; immunogenicity; interferon-gamma; interleukin-10; leishmaniasis; mice; models; parasite load; parasites; pathogenesis; pathogenicity; spleen;     Show all 16 Subjects
Abstract:
... Leishmania (L.) tropica is a causative agent of cutaneous and occasionally visceral or viscerotropic leishmaniasis in humans. The dose of parasites influences the course and outcome of disease in some Leishmania species. The effect of parasite dose on L. tropica infection in an experimental model was studied in the current paper. High and low doses of L. tropica were used for ear infection of BALB ...
DOI:
10.1007/s00436-018-5991-7

2. Absence of IL-17A in Litomosoides sigmodontis-infected mice influences worm development and drives elevated filarial-specific IFN-γ

Author:
Ritter, Manuel; Krupp, Vanessa; Wiszniewsky, Katharina; Wiszniewsky, Anna; Katawa, Gnatoulma; Tamadaho, Ruth S. E.; Hoerauf, Achim; Layland, Laura E.
Source:
Parasitology research 2018 v.117 no.8 pp. 2665-2675
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; Litomosoides sigmodontis; adults; blindness; chemokine CCL11; chemokine CCL17; climate; humans; immune response; interferon-gamma; interleukin-17; interleukin-21; interleukin-4; interleukin-6; mice; onchocerciasis; parasites; public health; secretion; socioeconomics; thoracic cavity; tropical diseases;     Show all 23 Subjects
Abstract:
... Lymphatic filariasis, onchocerciasis and loiasis are widespread neglected tropical diseases causing serious public health problems and impacting the socio-economic climate in endemic communities. More than 100 million people currently suffer from filarial infections but disease-related symptoms and infection-induced immune mechanisms are still ambiguous. Although most infected individuals have dom ...
DOI:
10.1007/s00436-018-5959-7

3. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis

Author:
Tong, Xinxin; Chen, Shengjie; Zheng, Huanqin; Huang, Shiguang; Lu, Fangli
Source:
Parasitology research 2018 v.117 no.7 pp. 2255-2263
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Toxoplasma gondii; animal models; cell lines; eyes; fluorescent antibody technique; histopathology; humans; immune response; immunopathology; interleukins; intraocular injection; mast cells; messenger RNA; mice; reverse transcriptase polymerase chain reaction; staining; surface antigens; tachyzoites; toluidine blue; toxoplasmosis;     Show all 21 Subjects
Abstract:
... Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxopla ...
DOI:
10.1007/s00436-018-5914-7

4. A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune response to Leishmania major in BALB/C

Author:
Mortazavidehkordi, Nahid; Fallah, Ali; Abdollahi, Abbas; Kia, Vahid; Khanahmad, Hossein; Najafabadi, ZahraGhayour; Hashemi, Nooshin; Estiri, Bahareh; Roudbari, Zahra; Najafi, Ali; Farjadfar, Akbar; Hejazi, SeyedHossein
Source:
Parasitology research 2018 v.117 no.7 pp. 2265-2273
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Leishmania major; Lentivirus; Western blotting; amastigotes; antibodies; antigens; cell-mediated immunity; enzyme-linked immunosorbent assay; hydrophilicity; immune response; immunoglobulin G; interferon-gamma; interleukin-10; leishmaniasis; macrophages; membrane proteins; mice; parasite load; promastigotes; recombinant vaccines; reverse transcriptase polymerase chain reaction; spleen; surface proteins; vaccination; vaccine development;     Show all 26 Subjects
Abstract:
... Hydrophilic acylated surface protein B (HASPB) is an immunogenic Leishmania-specific protein that antibodies are produced against it in the sera of Leishmania-infected individuals. Kinetoplastid membrane protein 11 (KMP11) is another Leishmania antigen and considered as the suitable candidate for vaccine development Leishmaniasis. It is a highly conserved surface protein expressed in both promasti ...
DOI:
10.1007/s00436-018-5915-6