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You searched for: Journal name Pathogens Remove constraint Journal name: Pathogens Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.11 no.1 Remove constraint Source: 2022 v.11 no.1
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1. Analysis of the Effects of Food Additives on Porphyromonas gingivalis

Author:
Mai Shinohara; Miki Maetani; Chiharu Kitada; Yasuko Nishigami; Ayaka Yazawa; Shigeki Kamitani
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Porphyromonas gingivalis; acesulfame potassium; antibacterial properties; aspartame; biofilm; cytotoxicity; decanoic acid; dysphagia; elderly; humans; octanoic acid; pathogens; plankton; saccharin; sucralose
Abstract:
... This study aims to investigate six food additives (octanoic acid, decanoic acid, acesulfame K, aspartame, saccharin, and sucralose) used in foods for the elderly or people with dysphagia because of the effect of these food additives on Porphyromonas gingivalis (P. gingivalis), which is a keystone pathogen of periodontal diseases. The growth of P. gingivalis was inhibited by 5 mM octanoic acid, 1.2 ...
DOI:
10.3390/pathogens11010065

2. Arboviral Disease Outbreaks in the Pacific Islands Countries and Areas, 2014 to 2020: A Systematic Literature and Document Review

Author:
Rosie J. Matthews; Ishani Kaluthotage; Tanya L. Russell; Tessa B. Knox; Paul F. Horwood; Adam T. Craig
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
One Health initiative; arboviruses; dengue; monitoring; public health; systematic review; Pacific Ocean Islands
Abstract:
... Arthropod-borne diseases pose a significant public health threat, accounting for greater than 17% of infectious disease cases and 1 million deaths annually. Across Pacific Island countries and areas (PICs), outbreaks of dengue, chikungunya, and Zika are increasing in frequency and scale. Data about arbovirus outbreaks are incomplete, with reports sporadic, delayed, and often based solely on syndro ...
DOI:
10.3390/pathogens11010074

3. Biological Control of Fusarium culmorum, Fusarium graminearum and Fusarium poae by Antagonistic Yeasts

Author:
Izabela Podgórska-Kryszczuk; Ewa Solarska; Monika Kordowska-Wiater
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Fusarium culmorum; Fusarium graminearum; Fusarium poae; antagonism; antagonists; biological control; chitinase; metabolites; mycelium; mycotoxins; phytotoxicity; siderophores; spore germination; wheat; yeasts
Abstract:
... The genus Fusarium is considered to be one of the most pathogenic, phytotoxic and toxin-producing group of microorganisms in the world. Plants infected by these fungi are characterized by a reduced consumer and commercial value, mainly due to the contamination of crops with mycotoxins. Therefore, effective methods of reducing fungi of the genus Fusarium must be implemented already in the field bef ...
DOI:
10.3390/pathogens11010086

4. The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

Author:
Anthony K. L. Leung; Diane E. Griffin; Jürgen Bosch; Anthony R. Fehr
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Alphavirus; COVID-19 infection; DNA-directed RNA polymerase; Orthocoronavirinae; antiviral agents; interferons; pandemic; pathogenesis; proteinases; public health; therapeutics; virus replication
Abstract:
... Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonstrated that the world was least prepared to provide effective treatments. This lack of preparedness has been due, in large part, to a lack of investmen ...
DOI:
10.3390/pathogens11010094

5. Current Understanding of the Pathogenesis of Porcine Circovirus 3

Author:
Chaitawat Sirisereewan; Roongroje Thanawongnuwech; Roongtham Kedkovid
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Porcine circovirus-3; diarrhea; pathogenesis; single-stranded DNA; swine
Abstract:
... Circoviruses are closed, circular, single-stranded DNA viruses belonging to the family Circoviridae and the genus Circovirus. To date, at least four porcine circoviruses (PCVs) have been recognized, including PCV1 to PCV4, respectively. Similar to PCV2 pathogenesis, PCV3 has been reported worldwide with myriad clinical and pathological presentations such as reproductive disorders, respiratory dise ...
DOI:
10.3390/pathogens11010064

6. Deltamethrin Application on Pre-Weaned Calves Improves Feed Consumption, Stress and Fatigue Status under Heat Stress Conditions

Author:
Konstantinos V. Arsenopoulos; Eleftherios Triantafillou; Athanasios I. Gelasakis; Elias Papadopoulos
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Holstein; Musca domestica; blood serum; cortisol; creatine kinase; deltamethrin; feed intake; feeds; heat stress; insect infestations; summer; Greece
Abstract:
... Fly infestation remains a universal problem for dairy cattle herds, affecting the animals’ health and welfare status. Pre-weaned dairy calves are significantly challenged by the direct and indirect consequences of severe fly infestation, heat-stress and their interaction, which contribute to a stressful and fatiguing environment. Among several physiological, behavioral, clinical and biochemical tr ...
DOI:
10.3390/pathogens11010085

7. Diagnosis and Treatment of Local Allergic Rhinitis

Author:
Tetsuya Terada; Ryo Kawata
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
allergens; allergic rhinitis; asthma; atopy; blood serum; diagnostic techniques; drug therapy; immunotherapy; nose
Abstract:
... Some patients with chronic rhinitis have a positive nasal allergen provocation test (NAPT) without systemic IgE sensitization by skin prick tests or serum allergen-specific IgE (sIgE). This novel concept is called local allergic rhinitis (LAR) and affects children and adults worldwide, but is underdiagnosed. LAR is not just the initial state of allergic rhinitis (AR), it is a unique form of chroni ...
DOI:
10.3390/pathogens11010080

8. The E3 Ubiquitin Ligase ATL9 Affects Expression of Defense Related Genes, Cell Death and Callose Deposition in Response to Fungal Infection

Author:
Tingwei Guo; Feng Kong; Carter Burton; Steven Scaglione; Blake Beagles; Justin Ray; Katrina M. Ramonell
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Arabidopsis thaliana; Golovinomyces; callose; cell death; fungi; pathogens; proteasome endopeptidase complex; signal transduction; ubiquitin-protein ligase; ubiquitination
Abstract:
... Plants use diverse strategies to defend themselves from biotic stresses in nature, which include the activation of defense gene expression and a variety of signal transduction pathways. Previous studies have shown that protein ubiquitination plays a critical role in plant defense responses, however the details of its function remain unclear. Our previous work has shown that increasing expression l ...
DOI:
10.3390/pathogens11010068

9. Ecology of Ixodes pacificus Ticks and Associated Pathogens in the Western United States

Author:
Molly McVicar; Isabella Rivera; Jeremiah B. Reyes; Monika Gulia-Nuss
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Bartonella; Borrelia burgdorferi; Ixodes pacificus; Lyme disease; Odocoileus hemionus; Oregon; Peromyscus maniculatus; Rickettsiales; Sceloporus occidentalis; adults; atmospheric precipitation; deer; forests; geographical distribution; habitats; humans; spring; ticks; California
Abstract:
... Lyme disease is the most important vector-borne disease in the United States and is increasing in incidence and geographic range. In the Pacific west, the western black-legged tick, Ixodes pacificus Cooley and Kohls, 1943 is an important vector of the causative agent of Lyme disease, the spirochete, Borrelia burgdorferi. Ixodes pacificus life cycle is expected to be more than a year long, and all ...
DOI:
10.3390/pathogens11010089

10. Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients

Author:
Momen Askoura; Hisham A. Abbas; Hadeel Al Sadoun; Wesam H. Abdulaal; Amr S. Abu Lila; Khaled Almansour; Farhan Alshammari; El-Sayed Khafagy; Tarek S. Ibrahim; Wael A. H. Hegazy
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Hepatitis C virus; biomarkers; blood serum; chronic hepatitis C; disease progression; fibrosis; hepatoma; inflammation; interleukin-17; liver; liver cirrhosis; viral load
Abstract:
... Hepatitis C virus (HCV) is one of the most epidemic viral infections in the world. Three-quarters of individuals infected with HCV become chronic. As a consequence of persistent inflammation, a considerable percentage of chronic patients progress to liver fibrosis, cirrhosis, and finally hepatocellular carcinoma. Cytokines, which are particularly produced from T-helper cells, play a crucial role i ...
DOI:
10.3390/pathogens11010057

11. Embedding of HIV Egress within Cortical F-Actin

Author:
Anupriya Aggarwal; Alberto Ospina Stella; Catherine C. Henry; Kedar Narayan; Stuart G. Turville
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
actin; genes; microfilaments; mutagenesis; proteomics; virion
Abstract:
... F-Actin remodeling is important for the spread of HIV via cell–cell contacts; however, the mechanisms by which HIV corrupts the actin cytoskeleton are poorly understood. Through live cell imaging and focused ion beam scanning electron microscopy (FIB-SEM), we observed F-Actin structures that exhibit strong positive curvature to be enriched for HIV buds. Virion proteomics, gene silencing, and viral ...
DOI:
10.3390/pathogens11010056

12. Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma

Author:
Fábio Alves Olímpio; Luiz Fábio Magno Falcão; Marcos Luiz Gaia Carvalho; Jeferson da Costa Lopes; Caio Cesar Henriques Mendes; Arnaldo Jorge Martins Filho; Carlos Augusto Moreira da Silva; Vanessa do Socorro Cabral Miranda; Lais Carneiro dos Santos; Fellipe Souza da Silva Vilacoert; Ana Cecília Ribeiro Cruz; Vanessa Costa Alves Galúcio; Raimunda do Socorro da Silva Azevedo; Lívia Caricio Martins; Maria Irma Seixas Duarte; Jorge Rodrigues de Sousa; Pedro Fernando da Costa Vasconcelos; Juarez Antônio Simões Quaresma
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Yellow fever virus; adhesion; endothelium; host-pathogen relationships; immunohistochemistry; inflammation; intercellular adhesion molecule-1; liver; parenchyma (animal tissue); prototypes; vascular cell adhesion molecules; yellow fever
Abstract:
... Yellow fever (YF) is a pansystemic disease caused by the yellow fever virus (YFV), the prototype species of the family Flaviviridae and genus Flavivirus, and has a highly complex host-pathogen relationship, in which endothelial dysfunction reflects viral disease tropism. In this study, the in situ endothelial response was evaluated. Liver tissue samples were collected from 21 YFV-positive patients ...
DOI:
10.3390/pathogens11010101

13. Enteroviral Infections in the First Three Months of Life

Author:
Marcello Sandoni; Lidia Ciardo; Caterina Tamburini; Alessandra Boncompagni; Cecilia Rossi; Isotta Guidotti; Elisabetta Garetti; Licia Lugli; Lorenzo Iughetti; Alberto Berardi
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Enterovirus; RNA; central nervous system; cerebrospinal fluid; complications (disease); feces; hepatitis; infancy; molecular epidemiology; mortality; myocarditis; polymerase chain reaction; serotypes; throat
Abstract:
... Enteroviruses (EVs) are an important source of infection in the paediatric age, with most cases concerning the neonatal age and early infancy. Molecular epidemiology is crucial to understand the circulation of main serotypes in a specific area and period due to their extreme epidemiological variability. The diagnosis of EVs infection currently relies on the detection of EVs RNA in biological sampl ...
DOI:
10.3390/pathogens11010060

14. Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria

Author:
Cyrine Bouabid; Yoshiki Yamaryo-Botté; Sameh Rabhi; Haifa Bichiou; Chaima Hkimi; Wafa Bouglita; Melek Chaouach; Naouel Eddaikra; Kais Ghedira; Lamia Guizani-Tabbane; Cyrille Y. Botté; Imen Rabhi
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Canidae; Leishmania major; biomarkers; computer simulation; cutaneous leishmaniasis; drugs; fatty acids; humans; immune response; lipidomics; parasites; phospholipids; rodents; vector-borne diseases; Algeria; Mediterranean region; Tunisia
Abstract:
... Leishmaniasis is a protozoal vector-borne disease that affects both humans and animals. In the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents and canids. Lipidomic approaches have allowed scientists to establish Leishmania spp. lipid profiles for the identification of cell stage specific biomarkers, drug mechanisms of action, and host immune response. Using ...
DOI:
10.3390/pathogens11010092

15. Genetic Characterization and Variation of African Swine Fever Virus China/GD/2019 Strain in Domestic Pigs

Author:
Xun Wang; Xiaoying Wang; Xiaoxiao Zhang; Sheng He; Yaosheng Chen; Xiaohong Liu; Chunhe Guo
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
African swine fever; African swine fever virus; DNA; blood; farms; frameshift mutation; genetic variation; genotype; phylogeny; China; Estonia
Abstract:
... African swine fever (ASF) was first introduced into Northern China in 2018 and has spread through China since then. Here, we extracted the viral DNA from the blood samples from an ASF outbreak farm in Guangdong province, China and sequenced the whole genome. We assembled the full length genomic sequence of this strain, named China/GD/2019. The whole genome was 188,642 bp long (terminal inverted re ...
DOI:
10.3390/pathogens11010097

16. Giardia duodenalis in Wildlife: Exploring Genotype Diversity in Italy and across Europe

Author:
Isabel Guadano Procesi; Margherita Montalbano Di Filippo; Claudio De Liberato; Andrea Lombardo; Giuseppina Brocherel; Stefania Perrucci; David Di Cave; Federica Berrilli
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Canis lupus; Giardia lamblia; Hystrix cristata; Sus scrofa; chamois; genomics; genotype; geographical distribution; hosts; phylogeny; wild boars; wildlife; wolves; Italy
Abstract:
... Fragmented data are so far available on genotype diversity of G. duodenalis in wildlife in different countries in Europe, in particular, in Italy. In the present study, G. duodenalis sequences obtained from different Italian wild animals [12 porcupines (Hystrix cristata), 4 wild boars (Sus scrofa), 1 wolf (Canis lupus italicus), 6 Alpine chamois (Rupicapra rupicapra rupicapra)] were compared with ...
DOI:
10.3390/pathogens11010105

17. Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

Author:
Janine Zöllkau; Juliane Ankert; Mathias W. Pletz; Sasmita Mishra; Gregor Seliger; Silvia M. Lobmaier; Clarissa U. Prazeres Da Costa; Vera Seidel; Katharina von Weizsäcker; Alexandra Jablonka; Christian Dopfer; Michael Baier; Thomas Horvatits; Ingrid Reiter-Owona; Tanja Groten; Benjamin T. Schleenvoigt
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Orthohepevirus A; cohort studies; echinococcosis; fetal development; gestational age; hepatitis E; risk; schistosomiasis; serology; seroprevalence; Germany
Abstract:
... Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany ...
DOI:
10.3390/pathogens11010058

18. Host-Microbe Interaction on the Skin and Its Role in the Pathogenesis and Treatment of Atopic Dermatitis

Author:
Danuta Nowicka; Karolina Chilicka; Iwona Dzieńdziora-Urbińska
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Staphylococcus aureus; adhesion; atopic dermatitis; fungi; host-pathogen relationships; innate immunity; microbiome; pathogenesis; people
Abstract:
... Atopic dermatitis (AD) is a condition with a complex and unclear aetiology. Possible causes of AD encompass alterations in the structure and function of the epidermal barrier, disturbances in the skin microbiome, immune factors, allergens, bacterial and fungal infections as well as environmental and genetic factors. In patients with AD, acute skin lesions are colonized by a greater number of bacte ...
DOI:
10.3390/pathogens11010071

19. Immunization Trials with Recombinant Major Sperm Protein of the Bovine Lungworm Dictyocaulus viviparus

Author:
Andrea Springer; Christian von Holtum; Georg von Samson-Himmelstjerna; Christina Strube
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Dictyocaulus viviparus; adjuvants; antigens; arithmetics; fecundity; females; geometry; glutathione transferase; immunity; immunization; immunoglobulin G; live vaccines; lungworms; males; spermatozoa; subunit vaccines; temperate zones
Abstract:
... The lungworm Dictyocaulus viviparus is one of the most economically important bovine parasites in temperate climate regions. Following infection, D. viviparus induces a temporary protective immunity, and a vaccine based on attenuated, infective larvae is commercially available. However, due to several disadvantages of the live vaccine, the development of a recombinant subunit vaccine is highly des ...
DOI:
10.3390/pathogens11010055

20. Investigation of the Potential of Heterophil/Lymphocyte Ratio as a Biomarker to Predict Colonization Resistance and Inflammatory Response to Salmonella enteritidis Infection in Chicken

Author:
Mamadou Thiam; Astrid Lissette Barreto Sánchez; Jin Zhang; Jie Wen; Guiping Zhao; Qiao Wang
Source:
Pathogens 2022 v.11 no.1 pp. -
ISSN:
2076-0817
Subject:
Salmonella Enteritidis; biomarkers; blood serum; cecum; chickens; disease resistance; excision; financial economics; heterophils; human health; ileum; inflammation; interleukin-8; intestinal mucosa; liver; microbial load; pathogenicity islands; poultry industry
Abstract:
... Salmonella causes significant economic loss to the poultry industry and represents a real threat to human health. The region of difference 21 (ROD21) pathogenicity island removal is a genetic mechanism by which Salmonellaenteritidis (SE) invades the intestinal epithelium and induces systemic infection in mice. The heterophil/lymphocyte (H/L) ratio reflects the chicken’s robustness and immune syste ...
DOI:
10.3390/pathogens11010072