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You searched for: Journal name Peptides Remove constraint Journal name: Peptides Publication year rev 7989-2011 Remove constraint Publication year rev: 7989-2011 Source 2011 v.32 no.3 Remove constraint Source: 2011 v.32 no.3
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1. Antihypertensive effect of insect cells: In vitro and in vivo evaluation

Author:
Dorien Staljanssens; John Van Camp; Griet Herregods; Maarten Dhaenens; Dieter Deforce; Johan Van de Voorde; Guy Smagghe
Source:
Peptides 2011 v.32 no.3 pp. 526-530
ISSN:
0196-9781
Subject:
Bombyx mori; Drosophila melanogaster; Spodoptera frugiperda; animal disease models; animal ovaries; antihypertensive effect; digestion; enzymes; gastrointestinal system; hydrolysis; hypertension; in vivo studies; inhibitory concentration 50; insects; oral administration; rats; systolic blood pressure
Abstract:
... In this study, we investigated the in vitro ACE inhibitory and in vivo antihypertensive effect of insect cell extracts. The IC₅₀ of three insect cell lines from different type and insect species origin: S2 (embryo, Drosophila melanogaster), Sf21 (ovary, Spodoptera frugiperda) and Bm5 (ovary, Bombyx mori), were evaluated. Most interesting results were that the IC₅₀ values ranged between 0.4 and 0.9 ...
DOI:
10.1016/j.peptides.2010.08.011

2. Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism

Author:
Pablo Emiliano Cantón; Esmeralda Zanicthe Reyes; Iñigo Ruiz de Escudero; Alejandra Bravo; Mario Soberón
Source:
Peptides 2011 v.32 no.3 pp. 595-600
ISSN:
0196-9781
Subject:
Bacillus thuringiensis subsp. israelensis; Culex quinquefasciatus; crystal proteins; insecticidal properties; mutants; population; site-directed mutagenesis; synergism; toxicity; toxins
Abstract:
... Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and Cyt named Cry4Aa, Cry4Ba, Cry11Aa and Cyt1Aa. Cyt1Aa enhances the activity of Cry4Aa, Cry4Ba or Cry11Aa and overcomes resistance of Culex quinquefasciatus populations resistant to Cry ...
DOI:
10.1016/j.peptides.2010.06.005
PubMed:
20558220
PubMed Central:
PMC2990805

3. Identification of a cysteine-rich antimicrobial peptide from salivary glands of the tick Rhipicephalus haemaphysaloides

Author:
Houshuang Zhang; Wenjie Zhang; Xinzhi Wang; Yongzhi Zhou; Na Wang; Jinlin Zhou
Source:
Peptides 2011 v.32 no.3 pp. 441-446
ISSN:
0196-9781
Subject:
Escherichia coli; Gram-negative bacteria; Pseudomonas aeruginosa; Rhipicephalus; Salmonella Typhimurium; adenosine monophosphate; antimicrobial peptides; cDNA libraries; chymotrypsin; complementary DNA; databases; females; genes; growth retardation; hemocoel; hemolysis; immune response; molecular weight; open reading frames; pathogens; recombinant proteins; salivary glands; suppression subtractive hybridization; ticks
Abstract:
... The presence of an effective immune response in the hemocoel of ticks is crucial for survival, as it prevents the invasion of pathogens throughout the animal's body. Antimicrobial peptides (AMPs) play an important role in this response by rapidly killing invading microorganisms. In this study, a subtraction hybridization cDNA library was constructed from the salivary glands of the unfed and fed fe ...
DOI:
10.1016/j.peptides.2010.12.004

4. In vitro activity of pacifastin-like inhibitors in relation to their structural characteristics

Author:
Bert Breugelmans; Vincent van Hoef; Gert Simonet; Sofie Van Soest; Guy Smagghe; Jozef Vanden Broeck
Source:
Peptides 2011 v.32 no.3 pp. 539-544
ISSN:
0196-9781
Subject:
Schistocerca gregaria; active sites; arthropods; digestive enzymes; mammals; peptidases; peptides
Abstract:
... Information on the structural characteristics and inhibitory activity of the pacifastin family is restricted to a handful of locust pacifastin-related inhibitors. In this report the optimization of a bacterial recombinant expression system is described, resulting in the high yield production of pacifastin-like inhibitors of the desert locust. Subsequently, the relative inhibitory activity of these ...
DOI:
10.1016/j.peptides.2010.08.006

5. Influence of codon usage bias on FGLamide-allatostatin mRNA secondary structure

Author:
Francisco Martínez-Pérez; William G. Bendena; Belinda S.W. Chang; Stephen S. Tobe
Source:
Peptides 2011 v.32 no.3 pp. 509-517
ISSN:
0196-9781
Subject:
aspartate transaminase; invertebrates; biosynthesis; Crustacea; messenger RNA; neuropeptides; codons; amino acids; juvenile hormones; insects; Blattodea
Abstract:
... The FGLamide allatostatins (ASTs) are invertebrate neuropeptides which inhibit juvenile hormone biosynthesis in Dictyoptera and related orders. They also show myomodulatory activity. FGLamide AST nucleotide frequencies and codon bias were investigated with respect to possible effects on mRNA secondary structure. 367 putative FGLamide ASTs and their potential endoproteolytic cleavage sites were ide ...
DOI:
10.1016/j.peptides.2010.10.007

6. Isolation and characterization of a novel myoactive tetradecapeptide-related peptide isolated from the brain of the squid, Todarodes pacificus

Author:
Hye-Jin Go; Eun Hee Jo; Jung-Kil Seo; Yong-Ki Hong; Hyung Ho Lee; Gun Do Kim; Tae Wook Park; Edward J. Noga; Nam Gyu Park
Source:
Peptides 2011 v.32 no.3 pp. 447-453
ISSN:
0196-9781
Subject:
Annelida; Gastropoda; Todarodes pacificus; bioactive properties; bioassays; brain; complementary DNA; esophagus; signal peptide; smooth muscle; squid
Abstract:
... A new bioactive tetradecapeptide, GFKDNVSNRIAHGFamide, was isolated from the brain of the squid, Todarodes pacificus. Using isolated T. pacificus esophagus as a bioassay, the peptide was shown to induce potent contraction of smooth muscle. The threshold concentration for contraction was 5×10⁻¹⁰M to 1×10⁻⁹M. The peptide was homologous to other molluskan (class Gastropoda) and annelid myoactive tetr ...
DOI:
10.1016/j.peptides.2010.11.016

7. Isolation, cloning and expression of the Crustacean Cardioactive Peptide gene in the Chagas’ disease vector, Rhodnius prolixus

Author:
D.H. Lee; J.P. Paluzzi; I. Orchard; A.B. Lange
Source:
Peptides 2011 v.32 no.3 pp. 475-482
ISSN:
0196-9781
Subject:
RNA-directed DNA polymerase; central nervous system; disease vectors; Crustacea; in situ hybridization; Rhodnius prolixus; messenger RNA; neurons; translation (genetics); polymerase chain reaction; amino acid sequences; amino acids; salivary glands; exons; insects; introns; South America
Abstract:
... The blood-gorging bug, Rhodnius prolixus, is a major vector of Chagas’ disease in Central and South America. We have cloned and characterized the crustacean cardioactive peptide (CCAP) gene in R. prolixus. The RhoprCCAP gene contains five exons and four introns, and encodes a 129 amino acid prepropeptide, which following post-translation processing, produces CCAP. The predicted RhoprCCAP amino aci ...
DOI:
10.1016/j.peptides.2010.06.035

8. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function

Author:
J.M. Jimenez-Vargas; R. Restano-Cassulini; V. Quintero-Hernández; G.B. Gurrola; L.D. Possani
Source:
Peptides 2011 v.32 no.3 pp. 560-567
ISSN:
0196-9781
Subject:
Centruroides noxius; Escherichia coli; alanine; electrophysiology; genes; heterologous gene expression; humans; methionine; mouth; mutants; peptides; potassium channels; site-directed mutagenesis; toxicity; venoms
Abstract:
... Ergtoxin 1 (ErgTx1) is a 42 amino acid peptide purified from the venom of the Mexican scorpion Centruroides noxius Hoffmann, capable of blocking specifically human potassium channels of the ether-á-go-go-related gene family (hERG). This peptide binds to a partially overlapping site on the channel outer mouth, in which residues of the S5-P linker are critically involved. Here we describe results of ...
DOI:
10.1016/j.peptides.2010.06.018

9. Role of MAPK p38 in the cellular responses to pore-forming toxins

Author:
Helena Porta; Angeles Cancino-Rodezno; Mario Soberón; Alejandra Bravo
Source:
Peptides 2011 v.32 no.3 pp. 601-606
ISSN:
0196-9781
Subject:
bacteria; defense mechanisms; eukaryotic cells; mechanism of action; mitogen-activated protein kinase; permeability; plasma membrane; toxins
Abstract:
... Understanding the mechanism of action of pore-forming toxins (PFTs) produced by different bacteria, as well as the host responses to toxin action, would provide ways to deal with these pathogenic bacteria. PFTs affect the permeability of target cells by forming pores in their plasma membrane. Target organisms may overcome these effects by triggering intracellular responses that have evolved as def ...
DOI:
10.1016/j.peptides.2010.06.012
PubMed:
20599578
PubMed Central:
PMC2994946

10. Serotonin has kinin-like activity in stimulating secretion by Malpighian tubules of the house cricket Acheta domesticus

Author:
Geoffrey Coast
Source:
Peptides 2011 v.32 no.3 pp. 500-508
ISSN:
0196-9781
Subject:
Acheta domesticus; Aedes aegypti; Malpighian tubules; Rhodnius prolixus; agonists; antagonists; calcium; corpora cardiaca; cyclic AMP; diuretic hormone; insects; larvae; potassium chloride; receptors; secretion; serotonin; sodium chloride
Abstract:
... Serotonin stimulates secretion by Malpighian tubules (MT) of a number of insects, and functions as a diuretic hormone in Rhodnius prolixus and in larval Aedes aegypti. Serotonin is here shown to be a potent stimulant of secretion by MT of the house cricket, Acheta domesticus, with an apparent EC₅₀ of 9.4nmolL⁻¹, although its diuretic activity is just 25% of the maximum achievable with either the n ...
DOI:
10.1016/j.peptides.2010.07.021

11. Venom peptides from solitary hunting wasps induce feeding disorder in lepidopteran larvae

Author:
Ji Hyeong Baek; Yeounjung Ji; Jeon-Soo Shin; Seunghwan Lee; Si Hyeock Lee
Source:
Peptides 2011 v.32 no.3 pp. 568-572
ISSN:
0196-9781
Subject:
Hymenoptera; Spodoptera exigua; antimicrobial peptides; disulfide bonds; erythrocytes; head; humans; insects; larvae; neurotoxicity; neurotoxins; permeability; preservatives; storage; thorax; venoms
Abstract:
... The cell lytic activity and toxicity against lepidopteran larvae of 13 venom peptides (4 OdVPs and 9 EpVPs) from two solitary hunting wasps, Orancistrocerus drewseni and Eumenes pomiformis, were examined with mastoparan as a reference peptide. Of the 13 peptides, 7 were predicted to have α-helical structures that exhibit the typical character of amphipathic α-helical antimicrobial peptides. The re ...
DOI:
10.1016/j.peptides.2010.12.007

12. The control of Malpighian tubule secretion in a predacious hemipteran insect, the spined soldier bug Podisus maculiventris (Heteroptera, Pentatomidae)

Author:
Geoffrey M. Coast; Ronald J. Nachman; Juan Lopez
Source:
Peptides 2011 v.32 no.3 pp. 493-499
ISSN:
0196-9781
Subject:
Zootermopsis nevadensis; Lepidoptera; serotonin; Rhodnius prolixus; secretion; Podisus maculiventris; hematophagy; peptides; Acrosternum hilare; Tenebrio molitor; diuretic hormone; larvae; Malpighian tubules; insects
Abstract:
... Spined soldier bugs, Podisus maculiventris, are heteropteran insects that feed voraciously on other insects, particular the soft bodied larval forms of Lepidoptera and Coleoptera. The response of P. maculiventris Malpighian tubules (MTs) to serotonin and known diuretic and antidiuretic peptides has been investigated, and is compared with that of MT from the hematophagous and phytophagous heteropte ...
DOI:
10.1016/j.peptides.2010.11.009

13. The first decapeptide adipokinetic hormone (AKH) in Heteroptera: A novel AKH from a South African saucer bug, Laccocoris spurcus (Naucoridae, Laccocorinae)

Author:
Heather G. Marco; Petr Simek; Gerd Gäde
Source:
Peptides 2011 v.32 no.3 pp. 454-460
ISSN:
0196-9781
Subject:
Aphelocheiridae; Naucoridae; adipokinetic hormone; amino acids; corpora cardiaca; hemolymph; lipid content; lipids; mass spectrometry; phylogeny; red pigment-concentrating hormone; swimming; synthetic peptides
Abstract:
... A novel peptide of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family has been elucidated by mass spectrometry from the corpora cardiaca of an African saucer bug species, Laccocoris spurcus. It is the first decapeptide member found in the species-rich taxon Heteroptera, has the primary sequence pGlu-Val-Asn-Phe-Ser-Pro-Ser-Trp-Gly-Gly amide and is denoted as Lacsp-AKH. ...
DOI:
10.1016/j.peptides.2010.10.015

14. Biostable multi-Aib analogs of tachykinin-related peptides demonstrate potent oral aphicidal activity in the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidae)

Author:
Ronald J. Nachman; Kamran Mahdian; Dick R. Nässel; R. Elwyn Isaac; Nan Pryor; Guy Smagghe
Source:
Peptides 2011 v.32 no.3 pp. 587-594
ISSN:
0196-9781
Subject:
antifeedants; peas; arthropods; artificial diets; hindgut; neuropeptides; Acyrthosiphon pisum; peptidyl-dipeptidase A; bioassays; pests; hydrolysis; lethal concentration 50; insects; Blattodea
Abstract:
... The tachykinin-related peptides (TRPs) are multifunctional neuropeptides found in a variety of arthropod species, including the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidae). Two new biostable TRP analogs containing multiple, sterically hindered Aib residues were synthesized and found to exhibit significantly enhanced resistance to hydrolysis by angiotensin converting enzyme and neprilysin, m ...
DOI:
10.1016/j.peptides.2010.09.013

15. Blockade of the release of the neuropeptide leucokinin to determine its possible functions in fly behavior: Chemoreception assays

Author:
Begoña López-Arias; Belén Dorado; Pilar Herrero
Source:
Peptides 2011 v.32 no.3 pp. 545-552
ISSN:
0196-9781
Subject:
Drosophila; axons; ganglia; mushroom bodies; nerve tissue; neuropeptides; odor compounds; parents; potassium channels; solvents
Abstract:
... Previous studies have revealed leucokinin (LK) expression in the brain and ventral ganglion of Drosophila CNS. One pair of protocerebrum neurons located in the lateral horn area (LHLK) surrounds the peduncles of the mushroom bodies while two pairs of subesophageal neurons (SELKs) project extended processes to the tritocerebrum and through a cervical connection to the ventral ganglion. There, axons ...
DOI:
10.1016/j.peptides.2010.07.002

16. The CCK(-like) receptor in the animal kingdom: Functions, evolution and structures

Author:
Dorien Staljanssens; Elnaz Karimian Azari; Olivier Christiaens; Jérôme Beaufays; Laurence Lins; John Van Camp; Guy Smagghe
Source:
Peptides 2011 v.32 no.3 pp. 607-619
ISSN:
0196-9781
Subject:
G-protein coupled receptors; Nematoda; agonists; antagonists; anxiety; arthropods; chemical structure; cholecystokinin; evolution; gall bladder; gastric acid; gastrointestinal motility; humans; ligands; memory; molecular models; pest control; satiety; secretion
Abstract:
... In this review, the cholecystokinin (CCK)(-like) receptors throughout the animal kingdom are compared on the level of physiological functions, evolutionary basis and molecular structure. In vertebrates, the CCK receptor is an important member of the G-protein coupled receptors as it is involved in the regulation of many physiological functions like satiety, gastrointestinal motility, gastric acid ...
DOI:
10.1016/j.peptides.2010.11.025

17. Design, synthesis and biological activity of peptidomimetic analogs of insect allatostatins

Author:
Yong Xie; Zhen Peng Kai; Stephen S. Tobe; Xi Le Deng; Yun Ling; Xiao Qin Wu; Juan Huang; Li Zhang; Xin Ling Yang
Source:
Peptides 2011 v.32 no.3 pp. 581-586
ISSN:
0196-9781
Subject:
Diploptera punctata; aspartate transaminase; bioactive properties; biosynthesis; corpora allata; inhibitory concentration 50; insect control; insects; juvenile hormones; neuropeptides
Abstract:
... Allatostatins (ASTs) comprise a family of insect neuropeptides isolated from cockroaches and found to inhibit the production of juvenile hormone (JH) by the corpora allata (CA). For this reason, the ASTs can be regarded as possible IGR candidates for pest control. Six peptidomimetic analogs according to the C-terminal pentapeptide of ASTs were prepared by solid-phase organic synthetic methods in a ...
DOI:
10.1016/j.peptides.2010.10.016

18. Distribution and characterization of Corazonin in the central nervous system of Triatoma infestans (Insecta: Heteroptera)

Author:
Beatriz P. Settembrini; Daniela de Pasquale; Melissa Postal; Paulo M. Pinto; Célia R. Carlini; Marcelo J. Villar
Source:
Peptides 2011 v.32 no.3 pp. 461-468
ISSN:
0196-9781
Subject:
Triatoma infestans; aorta; corpora cardiaca; cortex; immunohistochemistry; insects; matrix-assisted laser desorption-ionization mass spectrometry; nerve tissue; neurites; neuropeptides; optic lobe; thoracic ganglia
Abstract:
... The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass spectrometry in samples containing the brain, the subesophageal ganglion, the corpora cardiaca–corpus allatum complex and the anterior part of the aorta. Several groups of immunopositi ...
DOI:
10.1016/j.peptides.2010.10.020

19. Identification of kinin-related peptides in the disease vector, Rhodnius prolixus

Author:
Victoria Te Brugge; Jean-Paul Paluzzi; Susanne Neupert; Ronald J. Nachman; Ian Orchard
Source:
Peptides 2011 v.32 no.3 pp. 469-474
ISSN:
0196-9781
Subject:
Rhodnius prolixus; amino acids; disease vectors; genes; insects; kinins; matrix-assisted laser desorption-ionization mass spectrometry
Abstract:
... We have used an in silico approach to identify a gene from the blood-gorging vector, Rhodnius prolixus, that is predicted to produce an insect kinin prepropeptide. The prepropeptide is 398 amino acids in length and can potentially produce a large number of kinin-related peptides following post-translational processing. A comparison with other insect kinin precursor sequences demonstrates greatest ...
DOI:
10.1016/j.peptides.2010.10.002

20. Molecular cloning, characterization and expression analysis of cathepsin A gene in Chinese mitten crab, Eriocheir sinensis

Author:
Wei-Wei Li; Lin He; Xing-Kun Jin; Hui Jiang; Li-Li Chen; Ying Wang; Qun Wang
Source:
Peptides 2011 v.32 no.3 pp. 518-525
ISSN:
0196-9781
Subject:
messenger RNA; invertebrates; aquaculture; complementary DNA; Eriocheir sinensis; innate immunity; carboxypeptidase C; lysosomes; open reading frames; polymerase chain reaction; expressed sequence tags; vertebrates; Vibrio anguillarum; gene expression; amino acids; cDNA libraries; immune response; molecular cloning; hemocytes
Abstract:
... Cathepsins, a superfamily of hydrolytic enzymes produced and enclosed within lysosomes, function in immune response in vertebrates; however, their function within the innate immune system of invertebrates remains largely unknown. Therefore, we investigated the immune functionality of cathepsin A (catA) in Chinese mitten crab (Eriocheir sinensis), a commercially important and disease vulnerable aqu ...
DOI:
10.1016/j.peptides.2010.08.027