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- Yang, Guang‐Fu, et al. Show all 5 Authors
- Pest management science 2020 v.76 no.2 pp. 704-711
- Saccharomyces cerevisiae; aerobic conditions; antifungal properties; beta-sitosterol; cholesterol; genes; metabolites; molecular models; mutation; pest management; plant pathogenic fungi; prediction; proteins; toxicity; yeasts
- ... BACKGROUND: β‐Sitosterol is a plant metabolite with a broad range of anti‐fungal activity, however, this compound is not toxic against a few fungal species. The target of β‐sitosterol and the nature of its selective toxicity are not yet clear. Using a yeast model system and taking advantage of molecular biology and computational approaches, we identify the target and explain why β‐sitosterol is no ...