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1. Acute and sub-chronic toxicity of Cajanus cajan leaf extracts

Author:
Tang, Rong; Tian, Ru-hua; Cai, Jia-zhong; Wu, Jun-hui; Shen, Xiao-ling; Hu, Ying-jie
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1740-1746
ISSN:
1744-5116
Subject:
Cajanus cajan; acute toxicity; butanol; epididymis; ethanol; females; flavonoids; fractionation; hematology; high performance liquid chromatography; histopathology; kidneys; laboratory animals; leaf extracts; leaves; males; mice; mortality; oral administration; rats; stilbenes; testes; toxicity testing
Abstract:
... Context: The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported. Objective: This study examines the toxicological profiles of C. cajan leaf extracts. Materials and methods: The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichl ...
DOI:
10.1080/13880209.2017.1309556
PubMed:
28494681
PubMed Central:
PMC6130582

2. A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders

Author:
Mahmood, Hassan; Chaudhry, Mueen Ahmad; Masood, Zeeshan; Saeed, Muhammad Asad; Adnan, Sherjeel
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1017-1021
ISSN:
1744-5116
Subject:
Nepeta; acute toxicity; antidiarrheal effect; calcium; carbachol; data collection; jejunum; median effective concentration; mice; parasympatholytics; potassium; rabbits; tissues; verapamil
Abstract:
... Context: Nepeta ruderalis Buch.-Ham. (Lamiaceae), locally known as Badranj Boya, is an aromatic herb used traditionally as an antispasmodic, antidiarrhoeal, and anti-asthamatic remedy. Objective: Aqueous methanolic extract of N. ruderalis was studied to investigate its traditional uses. Materials and methods: Study was conducted from September 2015 to February 2016. In vitro spasmolytic and bronch ...
DOI:
10.1080/13880209.2017.1285325
PubMed:
28183233
PubMed Central:
PMC6130483

3. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism

Author:
Malik, Jai; Karan, Maninder; Dogra, Rachna
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 980-990
ISSN:
1744-5116
Subject:
3-nitropropionic acid; Celastrus paniculatus; antioxidant activity; body weight; brain; butanol; cognition; cortex; densitometry; ethanol; ethyl acetate; gait; herbal medicines; laboratory animals; linoleic acid; locomotion; males; medicinal properties; memory; nervous system diseases; neurons; oxidative stress; petroleum; plant extracts; protective effect; rats; seeds; thin layer chromatography
Abstract:
... Context: Celastrus paniculatus Wild. (Celasteraceae) (CP) is a well-known Ayurvedic ‘Medhya Rasayana’ (nervine tonic), used extensively as a neuro-protective and memory enhancer, and in different central nervous system disorders. Objective: To evaluate the effect of CP against 3-nitropropionic acid (3-NP) induced Huntington's disease (HD) like symptoms in Wistar male rats. Materials and methods: T ...
DOI:
10.1080/13880209.2017.1285945
PubMed:
28164735
PubMed Central:
PMC6130694

4. Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats

Author:
Dar, Parvaiz A.; Ali, Fasil; Sheikh, Ishfaq A.; Ganie, Showkat A.; Dar, Tanveer A.
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1849-1855
ISSN:
1744-5116
Subject:
Alcea rosea; albino; alloxan; analgesic effect; animal disease models; antioxidant activity; blood glucose; diabetes; fasting; glycemic effect; hydrogen peroxide; hyperglycemia; laboratory animals; liver; metformin; methanol; pancreas; rats; seed extracts; seeds; superoxide dismutase
Abstract:
... Context: Alcea rosea L. (Malvaceae) has various medicinal uses including anticancer, anti-inflammatory and analgesic properties. However, there is no report on its antidiabetic activity. Objective: Alcea rosea seed extracts were evaluated for antihyperglycaemic and antioxidative potential in diabetic rats. Materials and methods: Single intra-peritoneal injection of alloxan (130 mg/kg b.w.) was use ...
DOI:
10.1080/13880209.2017.1333127
PubMed:
28571499
PubMed Central:
PMC6130437

5. An ethnopharmacological study of aromatic Uyghur medicinal plants in Xinjiang, China

Author:
Zhao, Lu; Tian, Shuge; Wen, E.; Upur, Halmuart
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1114-1130
ISSN:
1744-5116
Subject:
ethnobotany; extinction; fruits; health services; indigenous knowledge; indigenous species; interviews; medicinal plants; medicinal properties; surveys; therapeutics; traditional medicine; villages; China; Europe; India; Mediterranean region
Abstract:
... Context: An ethnobotanical survey was completed in a remote village and surrounding country of Xinjiang, where most Uyghur medicinal plants could be collected. This work clarifies and increases ethnobotanical data. Objectives: We surveyed and organized aromatic medicinal plants that are commonly used in clinical settings to provide a significant reference for studying new medical activities. Mater ...
DOI:
10.1080/13880209.2016.1270971
PubMed:
28209076
PubMed Central:
PMC6130679

6. An evaluation of the anti-inflammatory, antipyretic and analgesic effects of hydroethanol leaf extract of Albizia zygia in animal models

Author:
Abotsi, Wonder Kofi Mensah; Lamptey, Stanley Benjamin; Afrane, Stephen; Boakye-Gyasi, Eric; Umoh, Ruth Uwa; Woode, Eric
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 338-348
ISSN:
1744-5116
Subject:
Albizia zygia; acetaminophen; analgesic effect; animal models; atropine; chicks; diclofenac; edema; fever; formalin test; leaf extracts; leaves; malaria; mechanism of action; morphine; naloxone; nonsteroidal anti-inflammatory agents; pain; theophylline; traditional medicine
Abstract:
... Context: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). Objectives: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. Materials and methods: Th ...
DOI:
10.1080/13880209.2016.1262434
PubMed:
27927089
PubMed Central:
PMC6130645

7. Anthelmintic efficacy of Clerodendrum viscosum on fowl tapeworm Raillietina tetragona

Author:
Nandi, Suranjana; Ukil, Bidisha; Roy, Saptarshi; Kundu, Suman; Lyndem, Larisha Mawkhlieng
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1401-1406
ISSN:
1744-5116
Subject:
Clerodendrum; Raillietina; Verbenaceae; death; drug therapy; electron microscopy; histology; in vitro studies; leaf extracts; organelles; pH; paralysis; permeability; phytochemicals; praziquantel; shrubs; tapeworms; India
Abstract:
... Context: Clerodendrum viscosum Vent. (Verbenaceae) is a shrub, widely used amongst the natives of India against various diseases. Objective: Crude extract of the plant was tested in vitro on a tapeworm Raillietina tetragona Molin (Davaineidae) to evaluate its potential anthelmintic efficacy and ultrastructural changes in the parasite. Materials and methods: Parasites were exposed to different conc ...
DOI:
10.1080/13880209.2016.1226367
PubMed:
27595160
PubMed Central:
PMC6130479

8. Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea

Author:
Nwidu, Lucky Legbosi; Elmorsy, Ekramy; Thornton, Jack; Wijamunige, Buddhika; Wijesekara, Anusha; Tarbox, Rebecca; Warren, Averil; Carter, Wayne Grant
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1875-1883
ISSN:
1744-5116
Subject:
2,2-diphenyl-1-picrylhydrazyl; Alzheimer disease; Carpolobia lutea; acetylcholinesterase; antioxidant activity; chloroform; cytotoxicity; dose response; ethanol; ethyl acetate; free radical scavengers; gallic acid; hepatocytes; hexane; humans; inhibitory concentration 50; leaves; methanol; oils; quercetin; roots; solvents; stems
Abstract:
... Context: There is an unmet need to discover new treatments for Alzheimer’s disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae). Objective: The objective of this study is to quantify C. lutea anti-AChE, DPPH free radical scavenging, and antioxidant activities and cell cytotoxi ...
DOI:
10.1080/13880209.2017.1339283
PubMed:
28629287
PubMed Central:
PMC6130458

9. Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera

Author:
Nguyen, Hoai Thi; Ho, Duc Viet; Vo, Hung Quoc; Le, Anh Tuan; Nguyen, Hien Minh; Kodama, Takeshi; Ito, Takuya; Morita, Hiroyuki; Raal, Ain
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 787-791
ISSN:
1744-5116
Subject:
Bacillus subtilis; Hedyotis; Mycobacterium smegmatis; Staphylococcus aureus; aerial parts; antibacterial properties; ceramides; chemical composition; ethyl acetate; fatty acids; glycosides; humans; lignans; mass spectrometry; methanol; minimum inhibitory concentration; nuclear magnetic resonance spectroscopy; oleanolic acid; quinones; screening; silica gel; steroids; therapeutics; traditional medicine
Abstract:
... Context: Hedyotis pilulifera (Pit.) T.N. Ninh (Rubiaceae) has been used in Vietnamese ethnomedicine; the methanol extract exhibited antibacterial activity in our preliminary screening. Objectives: In this study, compounds from H. pilulifera were isolated and their antibacterial activity in vitro was evaluated. Materials and methods: The aerial parts of H. pilulifera (1.4 kg) were extracted with Me ...
DOI:
10.1080/13880209.2017.1279673
PubMed:
28103726
PubMed Central:
PMC6130504

10. Antibacterial activity of aqueous and methanol extracts of selected species used in livestock health management

Author:
Mudzengi, Clarice P.; Murwira, Amon; Tivapasi, Musa; Murungweni, Chrispen; Burumu, Joan V.; Halimani, Tinyiko
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1054-1060
ISSN:
1744-5116
Subject:
Colophospermum mopane; Dichrostachys cinerea; Escherichia coli; Salvadora persica; Staphylococcus aureus; adverse effects; ampicillin; animal diseases; antibacterial properties; bacteria; bark; culture media; gentamicin; herbal medicines; leaves; livestock; methanol; minimum inhibitory concentration; plant extracts; roots
Abstract:
... Context: Salvadora persica L. (Salvadoraceae), Colophospermum mopane (J.Kirk ex Benth.) J. Léonard (Leguminosae) and Dichrostachys cinerea (L.) Wight & Arn. (Leguminosae) crude extracts are used by local farmers against many livestock infections with little or no side effects usually associated with synthetic antimicrobials. However, their efficacy has rarely been tested. Objective: These plants w ...
DOI:
10.1080/13880209.2017.1287744
PubMed:
28187694
PubMed Central:
PMC6130738

11. Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Author:
Nunes, Ricardo; Pasko, Pawel; Tyszka-Czochara, Malgorzata; Szewczyk, Agnieszka; Szlosarczyk, Marek; Carvalho, Isabel S.
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 114-123
ISSN:
1744-5116
Subject:
Bacillus cereus; Crataegus monogyna; Enterococcus faecalis; Equisetum telmateia; Escherichia coli; Geranium purpureum; Lavandula stoechas; Listeria monocytogenes; Mentha suaveolens; Pseudomonas aeruginosa; Staphylococcus aureus; aerial parts; antibacterial properties; antioxidant activity; antioxidants; ethanol; fibroblasts; herbs; high performance liquid chromatography; human cell lines; microorganisms; plant extracts; rosmarinic acid; solvents; voltammetry; zinc; Portugal
Abstract:
... Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zin ...
DOI:
10.1080/13880209.2016.1230636
PubMed:
27925492
PubMed Central:
PMC7011791

12. Anticarcinogenic activity of Muntingia calabura leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids

Author:
Md Nasir, Nur Liana; Kamsani, Noorsyaza Eddrina; Mohtarrudin, Norhafizah; Othman, Fezah; Md. Tohid, Siti Farah; Zakaria, Zainul Amiruddin
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 2102-2109
ISSN:
1744-5116
Subject:
Elaeocarpaceae; Muntingia calabura; anticarcinogenic activity; antineoplastic activity; antioxidant activity; antioxidants; azoxymethane; catalase; chemoprevention; colon; colorectal neoplasms; glutathione; high performance liquid chromatography; histopathology; laboratory animals; leaves; males; malondialdehyde; methanol; oxidants; polysorbates; rats; rutin; superoxide dismutase
Abstract:
... Context: Leaves of Muntingia calabura (Elaeocarpaceae) are widely used in traditional medical practice; scientific findings show various pharmacological activities. However, its anticancer effect has not been investigated thoroughly yet. Objective: The objective of this study is to study the chemoprevention effects of MEMCL against azoxymethane (AOM)-induced colon cancer and to examine the involve ...
DOI:
10.1080/13880209.2017.1371769
PubMed:
28872373
PubMed Central:
PMC6130576

13. Anti-cryptococcal activity of ethanol crude extract and hexane fraction from Ocimum basilicum var. Maria bonita: mechanisms of action and synergism with amphotericin B and Ocimum basilicum essential oil

Author:
Cardoso, Nathalia N. R.; Alviano, Celuta S.; Blank, Arie F.; Arrigoni-Blank, Maria de Fátima; Romanos, Maria Teresa V.; Cunha, Marcel M. L.; da Silva, Antonio Jorge R.; Alviano, Daniela S.
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1380-1388
ISSN:
1744-5116
Subject:
Cryptococcus gattii; Cryptococcus neoformans; Ocimum basilicum; amphotericin B; antifungal properties; ergosterol; essential oils; ethanol; headache; hexane; inoculum; intestines; kidney diseases; kidneys; leaves; mechanism of action; minimum inhibitory concentration; pigmentation; serotypes; synergism; traditional medicine
Abstract:
... Context: Ocimum basilicum L. (Lamiaceae) has been used in folk medicine to treat headaches, kidney disorders, and intestinal worms. Objective: This study evaluates the anti-cryptococcal activity of ethanol crude extract and hexane fraction obtained from O. basilicum var. Maria Bonita leaves. Materials and methods: The MIC values for Cryptococcus sp. were obtained according to Clinical and Laborato ...
DOI:
10.1080/13880209.2017.1302483
PubMed:
28317465
PubMed Central:
PMC6130641

14. Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats

Author:
Rahmati, Batool; Kiasalari, Zahra; Roghani, Mehrdad; Khalili, Mohsen; Ansari, Fariba
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 958-965
ISSN:
1744-5116
Subject:
Alzheimer disease; Lavandula angustifolia subsp. angustifolia; aerial parts; antidepressants; anxiety; dose response; elevated plus-maze test; forced swimming test; males; memory disorders; plant extracts; rats; scopolamine; swimming; tranquilizers
Abstract:
... Context: Anxiety and depression are common in Alzheimer’s disease (AD). Despite some evidence, it is difficult to confirm Lavandula officinalis Chaix ex Vill (Lamiaceae) as an anxiolytic and antidepressant drug. Objective: The effects of L. officinalis extract were studied in scopolamine-induced memory impairment, anxiety and depression-like behaviour. Materials and methods: Male NMRI rats were di ...
DOI:
10.1080/13880209.2017.1285320
PubMed:
28166686
PubMed Central:
PMC6130744

15. Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis

Author:
Chen, Yun; Zeng, Ling; Yang, Jingjing; Wang, Yixuan; Yao, Fangke; Wu, Yi; Wang, Deyun; Hu, Yuanliang; Liu, Jiaguo
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1545-1552
ISSN:
1744-5116
Subject:
B-lymphocytes; Duck hepatitis A virus; T-lymphocytes; adsorption; antibodies; cell proliferation; dose response; duck virus hepatitis; ducklings; enzyme-linked immunosorbent assay; flavonoids; interferon-gamma; interleukin-2; lymphocyte proliferation; poultry diseases; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; secretion; virus replication
Abstract:
... Context: The flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) has a curative effect on duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1). However, the mechanism of this curative effect is not understood. Objective: This study investigates the mechanism of the curative effect of BLIN on DVH caused by DHAV-1. We analyzed the anti-DHAV-1 reproduction ...
DOI:
10.1080/13880209.2017.1309554
PubMed:
28385083
PubMed Central:
PMC6130687

16. Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test

Author:
Lin, Chueh-Yu; Jhang, Yan-Shu; Lai, Shang-Chi; Chen, En-Li; Lin, I-Hsin; Chang, Tung-Wu; Tseng, Yu-Wei; Seenan, Vaishnavi; Shiung, Jane; Chen, Ming-Hua; Chiang, Yun-Chen; Chen, Tsung-I; Tzeng, Yin-Jeh
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 2264-2269
ISSN:
1744-5116
Subject:
Salvia miltiorrhiza; blood; blood glucose; forced swimming test; glycolysis; hypertrophy; lactic acid; malondialdehyde; mice; muscles; superoxide dismutase; swimming; urea nitrogen
Abstract:
... Context: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear. Objective: To study the antifatigue properties of Tan IIA and its underlying mechanisms. Materials and methods: In program I, three mouse groups were separately subjected to three gavages with 0, 1 and 6 mg/kg Tan IIA and forced swimming test (FST) ...
DOI:
10.1080/13880209.2017.1401648
PubMed:
29171356
PubMed Central:
PMC6130709

17. Anti-fibrotic effects of Cuscuta chinensis with in vitro hepatic stellate cells and a thioacetamide-induced experimental rat model

Author:
Kim, Jin Seoub; Koppula, Sushruta; Yum, Mun Jeong; Shin, Gwang Mo; Chae, Yun Jin; Hong, Seok Min; Lee, Jae Dong; Song, MinDong
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1909-1919
ISSN:
1744-5116
Subject:
Cuscuta; analytical kits; animal models; apoptosis; biomarkers; blood serum; cell cycle; cell viability; fibrosis; flow cytometry; gene expression; glutathione; histopathology; hydroxyproline; in vivo studies; kidney diseases; kidneys; laboratory animals; liver; rats; reverse transcriptase polymerase chain reaction; silymarin; spectrophotometers; staining; toxicity testing; traditional medicine; transforming growth factor beta 1
Abstract:
... Context: Cuscuta chinensis Lam. (Convolvulaceae) has been used as a traditional herbal remedy for treating liver and kidney disorders. Objective: Anti-fibrotic effects of C. chinensis extract (CCE) in cellular and experimental animal models were investigated. Materials and methods: HSC-T6 cell viability, cell cycle and apoptosis were analysed using MTT assay, flow cytometry and Annexin V-FITC/PI s ...
DOI:
10.1080/13880209.2017.1340965
PubMed:
28651481
PubMed Central:
PMC6130704

18. Antifungal and antioxidant activities of Coleonema album and C. pulchellum against skin diseases

Author:
Fajinmi, Olufunke O.; Grúz, Jiří; Tarkowski, Petr; Kulkarni, Manoj G.; Finnie, Jeffrey F.; Van Staden, Johannes
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 1249-1255
ISSN:
1744-5116
Subject:
Microsporum gypseum; Rutaceae; Trichophyton mentagrophytes; Trichophyton rubrum; antifungal properties; antioxidant activity; direct contact; essential oils; griseofulvin; ketoconazole; leaf extracts; methanol; minimum inhibitory concentration; mycelium; ointments; people; skin diseases; terpenoids; therapeutics; traditional medicine
Abstract:
... Context: Coleonema album (Thunb) Bart. & H. L. Wendl (Rutaceae) has been used in the formulation of skincare products, and the Khoisan people rub it on their skin to add luster. Coleonema pulchellum I. Williams has received less attention in the South African traditional medicine. Objective: This study investigates the antifungal and antioxidant activities of C. album and C. pulchellum essential o ...
DOI:
10.1080/13880209.2017.1296470
PubMed:
28262031
PubMed Central:
PMC6130550

19. Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa

Author:
Ibrahim, Mutiat; Kaushik, Nutan; Sowemimo, Abimbola; Chhipa, Hemraj; Koekemoer, Trevor; van de Venter, Maryna; Odukoya, Olukemi A.
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 590-595
ISSN:
1744-5116
Subject:
Bignoniaceae; Botrytis cinerea; Fusarium oxysporum; Sclerotinia; Spodoptera litura; Syncephalastrum racemosum; Thanatephorus cucumeris; Trichoderma longibrachiatum; anti-inflammatory activity; antifeedants; antifeeding activity; antineoplastic activity; antioxidants; cell lines; endophytes; fungi; inhibitory concentration 50; insect larvae; leaves; methanol; neoplasm cells; neoplasms; poisoning; sequence analysis; solvents
Abstract:
... Context: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. Objective: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. Material and methods: Endophytic fungi were isolated from t ...
DOI:
10.1080/13880209.2016.1263671
PubMed:
27937112
PubMed Central:
PMC6130725

20. Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats

Author:
Kouitcheu Mabeku, Laure Brigitte; Nanfack Nana, Blandine; Eyoum Bille, Bertrand; Tchuenteu Tchuenguem, Roland; Nguepi, Eveline
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 929-936
ISSN:
1744-5116
Subject:
Aframomum; Helicobacter pylori; adverse effects; anti-ulcer activity; etiological agents; gastritis; humans; indomethacin; methanol; minimum inhibitory concentration; mucus; nitric oxide; nonsteroidal anti-inflammatory agents; oral administration; plant extracts; rats; seeds; stomach ulcers
Abstract:
... Context: Peptic ulcer is one of the most common diseases affecting mankind. Although there are many products used for its treatment, most of these products produce severe adverse reactions requiring the search for novel compounds. Some Afromomum species are used traditionally to cure acute gastritis. Objective: To evaluate the antiulcer activity of the methanol extract of Aframomum pruinosum Gagne ...
DOI:
10.1080/13880209.2017.1285326
PubMed:
28164737
PubMed Central:
PMC6130624