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- Goodson, M.L.; Packard, A.E.B.; Buesing, D.R.; Maney, M.; Myers, B.; Fang, Y.; Basford, J.E.; Hui, D.Y.; Ulrich-Lai, Y.M.; Herman, J.P.; Ryan, Karen K.
- Physiology & behavior 2017 v.172 pp. 16-23
- animal models; atherosclerosis; collagen; coronary disease; corticosterone; death; males; psychological stress; rats; risk factors; stress response; therapeutics; tissues
- ... Prolonged and/or frequent exposure to psychological stress responses may lead to deterioration of organs and tissues, predisposing to disease. In agreement with this, chronic psychosocial stress is linked to greater cardiovascular risk, including increased incidence of atherosclerosis, myocardial ischemia, coronary heart disease, and death. Thus the association between stress and cardiovascular dy ...
- Statello, Rosario; Carnevali, Luca; Paterlini, Silvia; Gioiosa, Laura; Bertocchi, Ilaria; Oberto, Alessandra; Eva, Carola; Palanza, Paola; Sgoifo, Andrea
- Physiology & behavior 2017 v.172 pp. 31-39
- animal models; cardiac output; heart rate; hippocampus; knockout mutants; males; messenger RNA; mice; neural pathways; neuropeptide Y; normal values; psychological stress; receptors
- ... Central neuropeptide Y (NPY) signaling participates in the regulation of cardiac autonomic outflow, particularly via activation of NPY-Y1 receptors (Y1Rs). However, the specific brain areas and neural pathways involved have not been completely identified yet. Here, we evaluate the role of hippocampal Y1Rs in the modulation of the autonomic control of cardiac function using a conditional knockout m ...