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- Peris-Sampedro, Fiona; Basaure, Pia; Reverte, Ingrid; Cabré, Maria; Domingo, José L.; Colomina, Maria Teresa
- Physiology & behavior 2015 v.144 pp. 37-45
- Alzheimer disease; adults; animal models; apolipoprotein E; body weight changes; chlorpyrifos; chronic exposure; diet; epidemiological studies; genetic variation; genotype; human health; humans; males; memory; mice; neurodegenerative diseases; neurotoxicity; risk
- ... Despite restrictions on their use, humans are still constantly exposed to organophosphates (OPs). A huge number of studies have ratified the neurotoxic effects of chlorpyrifos (CPF) and suggested its association with neurodegenerative diseases, but data are still scarce. Human apolipoprotein E (apoE) plays an important role in lipid transport and distribution. In humans, the apoE4 isoform has been ...
- Khodamoradi, Nasrin; Komaki, Alireza; Salehi, Iraj; Shahidi, Siamak; Sarihi, Abdolrahman
- Physiology & behavior 2015 v.144 pp. 90-94
- analysis of variance; animal behavior; antioxidants; chronic exposure; cognition; data analysis; dose response; lead; lead acetate; males; memory; models; rats; vitamin E
- ... Chronic lead (Pb2+) exposure has been associated with learning and memory impairments, whereas vitamin E improves cognitive deficits. In this study, using a passive avoidance learning model in rats, we investigated the effects of vitamin E on Pb2+ exposure-induced learning and memory impairments in rats. In the present study, 56 Wistar male rats (weighting 230–250g) were divided into eight groups ...