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- Author:
- Antonio Sáenz-Castillo; Jean Sanabria-Chinchilla; Alfonso J. García-Piñeres; Giselle Tamayo-Castillo
- Source:
- Phytochemistry letters 2022 v.47 pp. 28-33
- ISSN:
- 1874-3900
- Subject:
- Piper; anti-inflammatory activity; antioxidants; cytotoxicity; electrochemistry; fractionation; inhibitory concentration 50; macrophages; mice; phytochemicals; voltammetry
- Abstract:
- ... A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in an LPS stimulated RAW 264.7 murine macrophage assay with IC50 values for inhibition of NO production of (18 ± 3) and (26 ± 5) μM, for 1 and 2, respectively. These compounds do n ...
- DOI:
- 10.1016/j.phytol.2021.10.018
- https://doi.org/10.1016/j.phytol.2021.10.018
- Author:
- Xiang-Mei Li; Cheng-Mei Yang; Li-Na Zhang; Xian-Jun Jiang; Guo-Zhu Wei; Fei Wang
- Source:
- Phytochemistry letters 2022 v.47 pp. 46-50
- ISSN:
- 1874-3900
- Subject:
- Tripterygium wilfordii; X-ray diffraction; cytotoxicity; ethanol; humans; inhibitory concentration 50; neoplasm cells; plant biochemistry; triterpenoids
- Abstract:
- ... Four hitherto unknown triterpenoids, including one euphane, namely wilfordeuphone (1), and three friedelanes, namely wilforic acids G − I (2–4), were isolated from the ethanol extract of the roots of Tripterygium wilfordii. The absolute configuration of 1 was established by single crystal X-ray diffraction. In addition, this study is the first to report euphane-type triterpenoid in the genus Tript ...
- DOI:
- 10.1016/j.phytol.2021.10.016
- https://doi.org/10.1016/j.phytol.2021.10.016
- Author:
- Yan Zhao; Yijia Zheng; Xin Chen; Rui Du; Zhaowei Yan
- Source:
- Phytochemistry letters 2021 v.46 pp. 79-89
- ISSN:
- 1874-3900
- Subject:
- 4',6-diamidino-2-phenylindole; antineoplastic activity; apoptosis; cell cycle; humans; inhibitory concentration 50; mortality; neoplasm cells; plant biochemistry; prostatic neoplasms
- Abstract:
- ... Malignant tumors are increasing the human mortality rate year by year, so there is an urgent need to develop novel and highly effective drugs. Camptothecin (CPT) is a natural medicinal product with broad-spectrum antitumor activity. In this study, 11 CPT derivatives were synthesized. Their antitumor activities were evaluated by CCK-8, morphological observation, plate cloning, scratching, DAPI stai ...
- DOI:
- 10.1016/j.phytol.2021.08.014
- https://doi.org/10.1016/j.phytol.2021.08.014
- Author:
- Nazlı Böke Sarıkahya; Ahmet C. Gören; Gaye Sümer Okkalı; Furkan Ozan Çöven; Batuhan Orman; Damla Kırcı; Banu Yücel; Duygu Kışla; Betül Demirci; Mehmet Altun; Ayşe Nur Önem; Ayşe Nalbantsoy
- Source:
- Phytochemistry letters 2021 v.44 pp. 129-136
- ISSN:
- 1874-3900
- Subject:
- Avian coronavirus; antioxidants; antiviral properties; caffeic acid; cell lines; chemical composition; chrysin; cosmetics; cytotoxicity; drugs; inhibitory concentration 50; limonene; macrophages; naringenin; nitric oxide; oleanolic acid; propolis
- Abstract:
- ... Propolis is a natural product with many biological activities, and it has been used in many industrial areas, such as pharmaceuticals, food and cosmetics. Thus, in this study, we aim to evaluate the chemical content, antioxidant, antiviral activities, cytotoxicity and the iNOS of propolis samples collected from 39 different regions in Turkey. Phenolic, flavonoid and triterpene profiles were determ ...
- DOI:
- 10.1016/j.phytol.2021.06.008
- https://doi.org/10.1016/j.phytol.2021.06.008
- Author:
- Xingyu Liu; Geng Wang; Chao Lv; Zhenbo Song; Yongli Bao; Shuyue Wang; Yanxin Huang
- Source:
- Phytochemistry letters 2021 v.46 pp. 15-20
- ISSN:
- 1874-3900
- Subject:
- acrylic acid; anti-inflammatory activity; benzaldehyde; dexamethasone; ferulic acid; glycosides; inhibitory concentration 50; lipopolysaccharides; luteolin; quercetin
- Abstract:
- ... Two new phenolic acids (1‒2), one new phenolic glycoside (3) and one new natural compound, 3-(4-hydroxy-3-methoxy-phenyl)acrylic acid carboxymethyl ester (6), together with eleven known polyphenolic substances, ferulic acid (4), ethyl ferulate (5), (E)-3–4-hydroxy-3-methoxyphenyl)acrylic acid (7), 3,4-dihydroxy benzaldehyde (8), quercetin (9), quercetin-3-O-glucopyranoside (10), luteolin (11), lut ...
- DOI:
- 10.1016/j.phytol.2021.09.007
- https://doi.org/10.1016/j.phytol.2021.09.007
- Author:
- Appolinaire Kene Dongmo; Raymond Ngansop Nono; Fatma Kaaniche; Isabelle Kamga Mawabo; Marcel Frese; Jean Rodolphe Chouna; Celine Nguefeu Nkenfou; Bruno Ndjakou Lenta; David Ngnokam; Pépin Nkeng-Efouet-Alango; Norbert Sewald
- Source:
- Phytochemistry letters 2020 v.36 pp. 134-138
- ISSN:
- 1874-3900
- Subject:
- Canthium; acetylcholinesterase; antibacterial properties; antioxidants; circular dichroism spectroscopy; cytotoxicity; enzyme inhibition; epicatechin; fruits; inhibitory concentration 50; metabolites; nuclear magnetic resonance spectroscopy; proanthocyanidins; spectral analysis
- Abstract:
- ... Phytochemical investigation of Canthium venosum fruits led to the isolation of a new doubly linked A-type proanthocyanidin trimer: epicatechin-(2β→O→7, 4β →8)-catechin-(5→O→2β, 6→4β)-epicatechin [venosumtannin A-1 (1)], along with twenty known compounds 2-21. Allyl (9a) and acetyl (9b) derivatives of 9 were prepared. The structures of compounds were established using comprehensive spectroscopic an ...
- DOI:
- 10.1016/j.phytol.2020.01.020
- https://doi.org/10.1016/j.phytol.2020.01.020
- Author:
- Chen Baosong; Wang Sixian; Liu Gaoqiang; Bao Li; Huang Ying; Zhao Ruilin; Liu Hongwei
- Source:
- Phytochemistry letters 2020 v.36 pp. 11-16
- ISSN:
- 1874-3900
- Subject:
- Staphylococcus aureus; Wolfiporia cocos; anti-inflammatory activity; antibacterial properties; circular dichroism spectroscopy; cytotoxicity; diterpenoids; inhibitory concentration 50; mushrooms; nitric oxide; nuclear magnetic resonance spectroscopy; pregnanes
- Abstract:
- ... Chemical investigation on the peels of the cultivated edible mushroom Wolfiporia cocos led to the identification of 13 diterpenes and 4 steroids, including two new abietane diterpenes (1 and 2) and one new pregnane steroid (14). Structures of new compounds were determined by analysis of NMR, MS, and electronic circular dichroism (ECD) data. All compounds were evaluated for cytotoxicity (K562 and H ...
- DOI:
- 10.1016/j.phytol.2020.01.005
- https://doi.org/10.1016/j.phytol.2020.01.005
- Author:
- Yu-Qing He; Liang Cai; Qun-Gang Qian; Sheng-Hui Yang; Di-Lu Chen; Bi-Qing Zhao; Zhen-Ping Zhong; Xiao-Jiang Zhou
- Source:
- Phytochemistry letters 2020 v.35 pp. 41-45
- ISSN:
- 1874-3900
- Subject:
- Carpesium abrotanoides; Influenza A virus; X-ray diffraction; cytotoxicity; herbs; human cell lines; inhibitory concentration 50; lactones; sesquiterpenoids; spectral analysis; viruses
- Abstract:
- ... Two new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11(13)-dehydroivaxillin (3), eriolin (4), 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (5), (5α)-5-hydroxyasperilin (6), 1α,4α-dihydroxy-guaia-11(13)-ene-12,8α-olide (7) and 4α,5α-dihydroxy-guaia-11(13)-en-12,8α-lactone (8), were isolated from the herbs of Carpesium abrotanoides L. The str ...
- DOI:
- 10.1016/j.phytol.2019.10.013
- https://doi.org/10.1016/j.phytol.2019.10.013
- Author:
- Nathalie S. Jouwa Tameye; Carine Mvot Akak; Gervais Mouthé Happi; Marcel Frese; Hans-Georg Stammler; Beate Neumann; Bruno Ndjakou Lenta; Norbert Sewald; Augustin E. Nkengfack
- Source:
- Phytochemistry letters 2020 v.36 pp. 63-67
- ISSN:
- 1874-3900
- Subject:
- Diospyros; X-ray diffraction; antimicrobial properties; antioxidant activity; antioxidants; beta-sitosterol; betulin; betulinic acid; carbon; inhibitory concentration 50; leaves; lupeol; mass spectrometry; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; ursolic acid
- Abstract:
- ... Two new norbergenin derivatives, 4-O-p-hydroxybenzoylnorbergenin (1) and 11-O-(E)-cinnamoylnorbergenin (2), were isolated from the leaves of Diospyros gilletii De Wild along with nine known compounds, including norbergenin (3), 4-O-galloylnorbergenin (4), betulin (5), betulinic acid (6), lupeol (7), ursolic acid (8), corosolic acid (9), β-sitosterol (10) and quercitol (11). Their structures were e ...
- DOI:
- 10.1016/j.phytol.2020.01.012
- https://doi.org/10.1016/j.phytol.2020.01.012
- Author:
- Lai-Bin Zhang; Hui-Hui Zhu; Li-Min Guo; Jie-Li Lv
- Source:
- Phytochemistry letters 2020 v.36 pp. 17-23
- ISSN:
- 1874-3900
- Subject:
- Artemisia argyi; IKappaB kinase; Oriental traditional medicine; X-ray diffraction; chemokines; cytoplasm; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; interleukin-1beta; lactones; lipopolysaccharides; macrophages; nitric oxide; phosphorylation; prostaglandin synthase; prostaglandins; protein synthesis; secretion; sesquiterpenoids; signal transduction; spectral analysis; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Artemargyinolide E (AE), a new sesquiterpene lactone was isolated from the traditional Chinese medicine Artemisia argyi. Its structure was elucidated based on the extensive analysis of spectroscopic data. The absolute configuration of AE was assigned by X-ray crystallographic analysis. The effect of AE and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages were ...
- DOI:
- 10.1016/j.phytol.2020.01.009
- https://doi.org/10.1016/j.phytol.2020.01.009
- Author:
- Basma Khalaf Mahmoud; Mamdouh Nabil Samy; Ashraf Nageeb Elsayed Hamed; Usama Ramadan Abdelmohsen; Dina Hajjar; Yoshi Yamano; Sachiko Sugimoto; Katsuyoshi Matsunami; Mohamed Salah Kamel
- Source:
- Phytochemistry letters 2020 v.35 pp. 200-205
- ISSN:
- 1874-3900
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Bignonia binata; Trypanosoma brucei brucei; antioxidant activity; antitrypanosomal properties; glucosides; inhibitory concentration 50; leaves; lignans; nuclear magnetic resonance spectroscopy
- Abstract:
- ... One new neolignan glucoside; bignanoside A (1) and one new iridoid glucoside; bignanoside B (2), and one new lignan rhamnoside; (-)-1yoniresinol 3α-O-α-L-rhamnopyranoside (3) reported for the first time, alongside with seven known compounds were isolated from Bignonia binata leaves. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D and 2D NMR e ...
- DOI:
- 10.1016/j.phytol.2019.12.009
- https://doi.org/10.1016/j.phytol.2019.12.009
- Author:
- Li-Tang Sun; Yao Chen; Hui-Xiang Yang; Zheng-Hui Li; Ji-Kai Liu; Guo-Kai Wang; Tao Feng
- Source:
- Phytochemistry letters 2020 v.37 pp. 29-32
- ISSN:
- 1874-3900
- Subject:
- Zopfiella; cytotoxicity; endophytes; fungi; inhibitory concentration 50; neoplasm cells; sesquiterpenoids
- Abstract:
- ... Three undescribed bisabolane sesquiterpenoids, zopfiellins A–C (1‒3), and one new α-pyrone derivative, zofiellone (4), have been isolated from cultures of the endophytic fungus Zopfiella sp. Compound 2 is a rare trinor-bisabolane sesquiterpenoid and 3 has an unusual aromatic core. Compounds 3 and 4 possess mild cytotoxicities against three human cancer cell lines with a range of IC₅₀ values from 1 ...
- DOI:
- 10.1016/j.phytol.2020.03.008
- https://doi.org/10.1016/j.phytol.2020.03.008
- Author:
- Jimei Liu; Jiamin Feng; Xiaona Jia; Jinlian Zhao; Ridao Chen; Kebo Xie; Dawei Chen; Yan Li; Jungui Dai
- Source:
- Phytochemistry letters 2020 v.35 pp. 73-77
- ISSN:
- 1874-3900
- Subject:
- Stachybotrys chartarum; cytotoxicity; human cell lines; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; oxygen; spectral analysis
- Abstract:
- ... Bistachybotrysins W-Y (1–3), three new phenylspirodrimane dimers with a 6/7 oxygen heterocycle as the linkage, were isolated from Stachybotrys chartarum CGMCC 3.5365. The structures of 1–3 were elucidated through extensive spectroscopic data analysis, including 1D/2D NMR, HR-ESI-MS, and ECD spectra. Compounds 1 and 3 displayed moderate cytotoxic activity against human tumor cell lines HCT116, Daoy ...
- DOI:
- 10.1016/j.phytol.2019.11.011
- https://doi.org/10.1016/j.phytol.2019.11.011
- Author:
- Duong H. Trinh; Phuong T. Tran; Binh T.D. Trinh; Hieu T. Nguyen; Hiep D. Nguyen; Ly D. Ha; Lien-Hoa D. Nguyen
- Source:
- Phytochemistry letters 2020 v.35 pp. 94-98
- ISSN:
- 1874-3900
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Rutaceae; acarbose; alkaloids; alpha-glucosidase; antioxidant activity; ascorbic acid; coumarins; enzyme inhibition; hexane; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; roots
- Abstract:
- ... Three new compounds comprising two coumarins, paramicoumarins A (1) and B (2), and an acridone alkaloid, paramiacridone (3), together with seven known compounds, were isolated from the n-hexane extract of the roots of Paramignya trimera (Rutaceae). Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. α-Glucosidase inhibition and DPPH radical scavenging activity of th ...
- DOI:
- 10.1016/j.phytol.2019.10.010
- https://doi.org/10.1016/j.phytol.2019.10.010
- Author:
- Siwattra Choodej; Khanitha Pudhom
- Source:
- Phytochemistry letters 2020 v.35 pp. 1-5
- ISSN:
- 1874-3900
- Subject:
- Euphorbia neriifolia; breast neoplasms; cytotoxicity; ethyl acetate; inhibitory concentration 50; leaves; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis; triterpenoids
- Abstract:
- ... Three new cycloartane terpenoids, neriifolins A–C (1-3), together with one known compound, 24-methylenecycloartane (4), were isolated from the EtOAc extract of the leaves of Euphorbia neriifolia Linn (Euphorbiaceae). The structures of the new compounds were elucidated based on extensive spectroscopic analyses, particularly 1D and 2D NMR, and HR-ESI-MS. Compounds 1-3 showed cytotoxicity against bre ...
- DOI:
- 10.1016/j.phytol.2019.10.005
- https://doi.org/10.1016/j.phytol.2019.10.005
- Author:
- Sariyarach Thanasansurapong; Patoomratana Tuchinda; Vichai Reutrakul; Manat Pohmakotr; Pawinee Piyachaturawat; Arthit Chairoungdua; Kanoknetr Suksen; Radeekorn Akkarawongsapat; Jitra Limthongkul; Chanita Napaswad; Narong Nuntasaen
- Source:
- Phytochemistry letters 2020 v.35 pp. 46-52
- ISSN:
- 1874-3900
- Subject:
- Gardenia; Human immunodeficiency virus 1; anticarcinogenic activity; antiviral properties; branches; cell lines; cytotoxicity; flavanones; giant cells; inhibitory concentration 50; leaves; median effective concentration; methanol; spectral analysis; triterpenoids
- Abstract:
- ... A new cycloartane triterpenoid, sessiliflorin (1), together with two new flavanones, 5,3′,5′-trihydroxy-6,7,4′-trimethoxyflavanone (10) and 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavanone (11) were isolated from a methanol extract of leaves and twigs of Gardenia sessiliflora. In addition, the known cycloartane triterpenoids 2–9 and flavonoids 12–21 were also obtained from the same source. All structu ...
- DOI:
- 10.1016/j.phytol.2019.10.007
- https://doi.org/10.1016/j.phytol.2019.10.007
- Author:
- Ye Ye; Guang-Hui Liu; Drolma Dawa; Li-Sheng Ding; Zhi-Xing Cao; Yan Zhou
- Source:
- Phytochemistry letters 2020 v.36 pp. 183-187
- ISSN:
- 1874-3900
- Subject:
- Euphorbia; cytotoxicity; diterpenoids; human cell lines; human diseases; in vitro studies; inhibitory concentration 50; mice; moieties; neoplasm cells; neoplasms; roots; spectral analysis
- Abstract:
- ... Three new diterpenoids, euphstrachenols A–C (1, 2, and 11), together with nineteen known analogues were isolated from the roots of Euphorbia stracheyi. Compounds 1 and 2 were lathyrane-type diterpenoids with a decadienoyl acidic moiety. Compound 11 was an ingenane-type diterpenoid with a deca-2′′E,4′′E,6′′E-trien-1-one moiety. Their structures were elucidated by comprehensive spectroscopic analyse ...
- DOI:
- 10.1016/j.phytol.2020.03.002
- https://doi.org/10.1016/j.phytol.2020.03.002
- Author:
- Tian-Xiao Li; Meng Yuan; Guo-Liang Zhao; Guo-Feng Yu; Ya-Mei Xiong; Xue-Wei Jia; Chun-Ping Xu
- Source:
- Phytochemistry letters 2020 v.38 pp. 1-5
- ISSN:
- 1874-3900
- Subject:
- Atractomorpha sinensis; Myrothecium roridum; antineoplastic agents; circular dichroism spectroscopy; cytotoxicity; digestive system; fungi; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; trichothecenes
- Abstract:
- ... Myrothecol A (1), a rare 10,13-cyclo macrocyclic trichothecene, and two known compounds (2 and 3) were isolated from the fungus Myrothecium roridum, which was obtained from the gut of a locust Atractomorpha sinensis Bolivar. Their structures and absolute configurations were determined through HRESIMS (high resolution electrospray ionization mass spectroscopy), NMR (nuclear magnetic resonance), ECD ...
- DOI:
- 10.1016/j.phytol.2020.04.003
- https://doi.org/10.1016/j.phytol.2020.04.003
- Author:
- Ke Zan; Xiao-Qing Chen; Ming-Bo Zhao; Yong Jiang; Peng-Fei Tu
- Source:
- Phytochemistry letters 2020 v.37 pp. 33-36
- ISSN:
- 1874-3900
- Subject:
- Artemisia; aerial parts; cytotoxicity; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; sesquiterpenoid lactones; spectral analysis
- Abstract:
- ... Chemical exploration of Artemisia myriantha Wall. ex Bess (Asteraceae) aerial parts afforded one new seco-guaianolide (1) and one new germacranolide (2). Structure elucidation of the new compounds was unambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. The two new compounds exhibited in vitro strong cytotoxic activities against human cancer cell lines HCT-8 with IC₅₀ va ...
- DOI:
- 10.1016/j.phytol.2020.03.009
- https://doi.org/10.1016/j.phytol.2020.03.009
- Author:
- Tran Thi Hong Hanh; Pham Thi Cham; Hoang Anh Do; Nguyen The Cuong; Hyuncheol Oh; Tran Hong Quang; Nguyen Xuan Cuong; Nguyen Hoai Nam; Chau Van Minh
- Source:
- Phytochemistry letters 2020 v.39 pp. 111-115
- ISSN:
- 1874-3900
- Subject:
- Plantago major; bioactive compounds; chemical structure; chromatography; circular dichroism spectroscopy; inhibitory concentration 50; iridoid glycosides; mass spectrometry; neuroglia; nitric oxide; nuclear magnetic resonance spectroscopy; phenylethyl alcohol
- Abstract:
- ... Using various chromatographic separations, five iridoid glucosides (1―5) and five phenylethanoid glycosides (6―10) were isolated from the Plantago major whole plants and included two new compounds: 10-acetylarborescoside (1) and plantainoside G (6). Their structures were elucidated by detailed analysis of 1D and 2D NMR data, HR QTOF MS data, and experimental and calculated ECD data. The isolated c ...
- DOI:
- 10.1016/j.phytol.2020.07.010
- https://doi.org/10.1016/j.phytol.2020.07.010
- Author:
- Ying-Xue Niu; Dun Wang; Xin-Yue Chu; Su-Yu Gao; Dong-Xin Yang; Li-Xia Chen; Hua Li
- Source:
- Phytochemistry letters 2020 v.35 pp. 186-190
- ISSN:
- 1874-3900
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Vitex negundo; antioxidant activity; ethanol; free radicals; inhibitory concentration 50; iridoid glycosides; leaves; plant extracts; spectral analysis
- Abstract:
- ... Two new iridoids (1-2) together with eight known iridoid glycosides (3-10) were isolated from the 70% EtOH extract of the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive spectroscopic analyses. Iridoid aglycones were found for the first time from this plant. All of these compounds were tested for their antioxidant activities. Among them, compound 9 sh ...
- DOI:
- 10.1016/j.phytol.2019.11.018
- https://doi.org/10.1016/j.phytol.2019.11.018
- Author:
- Daniel Zacharia Matata; Mainen Julius Moshi; Francis Machumi; Olipa David Ngassapa; Bresler Swanepoel; Kenneth Oosthuizen; Luanne Venables; Trevor Koekemoer; Matthias Heydenreich; Paul Erasto Kazyoba; Maryna van de Venter
- Source:
- Phytochemistry letters 2020 v.36 pp. 120-126
- ISSN:
- 1874-3900
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Artemia salina; Rhus; antioxidant activity; antioxidants; apoptosis; caspase-3; cold; cytotoxicity; ethyl acetate; human cell lines; inhibitory concentration 50; iron; larvae; lethal concentration 50; maceration; median effective concentration; methanol; methylene chloride; mitosis; neoplasm cells; petroleum; phosphatidylserines; root extracts; uterine cervical neoplasms; Tanzania
- Abstract:
- ... R. natalensis.Bernh ex C.Krauss (Anacardiaceae) is used by Traditional Health Practitioners (THPs) in Same district, north eastern Tanzania, for treatment of cancer and other diseases. The current study was done to determine its cytotoxic activity.Dried root powder was extracted by cold maceration with a 1:1 mixture of methanol and dichloromethane. Sequential VLC fractions (Petroleum ether, ethyl ...
- DOI:
- 10.1016/j.phytol.2020.01.024
- https://doi.org/10.1016/j.phytol.2020.01.024
- Author:
- Dong-Bo Zhang; Zheng Wang; Yan-Ni Liang; Jin-Gao Yu; Zhen Zhang; Shi-Jun Liu; Zhao Zhang; Zhong-Xing Song; Zhi-Shu Tang; Dong-Zhu Duan
- Source:
- Phytochemistry letters 2020 v.36 pp. 166-170
- ISSN:
- 1874-3900
- Subject:
- Jatropha integerrima; bark; chemical bonding; diterpenoids; humans; inhibitory concentration 50; isomers; mass spectrometry; nuclear magnetic resonance spectroscopy; protein-tyrosine-phosphatase
- Abstract:
- ... Three new 14-membered cembrane-type diterpenoids, jatrophainolides A–C (1−3), were isolated from the root bark of Jatropha integerrima Jacq. Thier structures were established on the basis of extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Of these isolates, compounds 1 and 2 were a pair of isomers with the E/Z configurations of Δ¹,² double bond. All compounds d ...
- DOI:
- 10.1016/j.phytol.2020.02.007
- https://doi.org/10.1016/j.phytol.2020.02.007
- Author:
- Ye Sun; Yan Liu; Yan-Ping Sun; Hong-Liang Ye; Juan Pan; Wei Guan; Bing-You Yang; Hai-Xue Kuang
- Source:
- Phytochemistry letters 2020 v.37 pp. 95-100
- ISSN:
- 1874-3900
- Subject:
- Clematis chinensis; aerial parts; cell lines; cytotoxicity; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; phenylpropanoids
- Abstract:
- ... Three new phenylpropanoids (lanicepsides C–E, 1–3) and twenty-two (4-25) known ones were isolated from the aerial part of Clematis chinensis Osbeck. Structure elucidation was performed by several spectroscopic techniques, including one and two-dimensional NMR spectra and HRESIMS. Compounds 4, 5, 8, 11–17 and 19-21 were reported from Clematis chinensis Osbeck for the first time. All compounds were ...
- DOI:
- 10.1016/j.phytol.2020.03.010
- https://doi.org/10.1016/j.phytol.2020.03.010
- Author:
- Lai Hop Hieu; Nguyen Phuong Thao; Do Hoang Anh; Tran Thi Hong Hanh; Nguyen Duy Cong; Nguyen The Cuong; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Ngo Dai Quang; Chau Van Minh
- Source:
- Phytochemistry letters 2020 v.37 pp. 116-120
- ISSN:
- 1874-3900
- Subject:
- Excoecaria; chemical structure; diterpenoids; inhibitory concentration 50; leaves; lipopolysaccharides; metabolites; nitric oxide; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... A new rhamnofolane-type diterpenoid (1) and a new phenolic derivative (2), together with eleven known compounds, were isolated from the leaves of E. cochinchinensis Lour. The chemical structures of these compounds were elucidated based on extensive spectroscopic analysis, including HR-QTOF-MS and NMR, and comparison with reported data. The inhibitory effects of compounds 1–13 on lipopolysaccharide ...
- DOI:
- 10.1016/j.phytol.2019.08.003
- https://doi.org/10.1016/j.phytol.2019.08.003
- Author:
- Qian Shao; Rui Ma; Xing Wu; Fa-Lei Zhang; Zheng-Hui Li; Tao Feng; Juan He; Ji-Kai Liu
- Source:
- Phytochemistry letters 2020 v.35 pp. 53-57
- ISSN:
- 1874-3900
- Subject:
- Melodinus; cell lines; cytotoxicity; fruits; indole alkaloids; inhibitory concentration 50; monoterpenoids; neoplasm cells; neoplasms; spectroscopy
- Abstract:
- ... Four undescribed monoterpenoid indole alkaloids, melodinines X₁‒X₄ (1‒4), together with fourteen known ones, have been isolated from the fruits of Melodinus henryi. Their structures with absolute configurations were elucidated by extensive spectroscopic methods and ECD calculations. Compound 1 shows a significant cytotoxicity to HL-60 cancer cell line with an IC₅₀ value of 0.8 μM. ...
- DOI:
- 10.1016/j.phytol.2019.11.003
- https://doi.org/10.1016/j.phytol.2019.11.003
- Author:
- Beom Zoo Lee; Ki Mo Kim; Sungwook Chae; Soon-Kyu Jeong; Sulhae Lee; KwangWon Hong; Ik Soo Lee
- Source:
- Phytochemistry letters 2020 v.35 pp. 78-83
- ISSN:
- 1874-3900
- Subject:
- Fraxinus chinensis subsp. rhynchophylla; active ingredients; bark; coumarins; elastase; humans; in vitro studies; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; neutrophils; nitric oxide; protein content; spectral analysis
- Abstract:
- ... Two new coumarins (1 and 2), together with six known compounds (3–8), were isolated from the stem bark of Fraxinus rhynchophylla. The structures of these compounds were established by extensive spectroscopic studies and chemical evidence. The inhibitory activities of the isolated compounds (1–8) against human neutrophil elastase (HNE) were evaluated in vitro; all compounds tested exhibited inhibit ...
- DOI:
- 10.1016/j.phytol.2019.11.005
- https://doi.org/10.1016/j.phytol.2019.11.005
- Author:
- Unang Supratman; Supriatno Salam; Wiro Naibaho; Mohamad Fajar; Nurlelasari; Dewa Gede Katja; Desi Harneti; Rani Maharani; Ace Tatang Hidayat; Ronny Lesmana; Mohamad Azlan Nafiah; Yoshihito Shiono
- Source:
- Phytochemistry letters 2020 v.35 pp. 63-67
- ISSN:
- 1874-3900
- Subject:
- Chisocheton; bark; breast neoplasms; chemical structure; cytotoxicity; hexane; inhibitory concentration 50; limonoids; neoplasm cells; nuclear magnetic resonance spectroscopy; plant extracts
- Abstract:
- ... Three new limonoids namely pentandricines B–D (1–3), were isolated from n-hexane extract of the stem bark of Chisocheton pentandrus, along with four known limonoids (4-7). The chemical structures of pentandricines B–D, were fully elucidated based on UV, IR, HR-TOFMS, 1D- and 2D-NMR spectra. Furthermore, compounds 1-7 were evaluated for their cytotoxic activity against MCF-7 breast cancer cells in ...
- DOI:
- 10.1016/j.phytol.2019.11.002
- https://doi.org/10.1016/j.phytol.2019.11.002
- Author:
- Ting Zhao; Xu-Hua Nong; Bin Zhang; Min-Min Tang; Dan-Yu Huang; Jia-Li Wang; Jun-Lu Xiao; Guang-Ying Chen
- Source:
- Phytochemistry letters 2020 v.36 pp. 115-119
- ISSN:
- 1874-3900
- Subject:
- Dracaena angustifolia; anti-inflammatory activity; flavones; inhibitory concentration 50; spectral analysis; stems
- Abstract:
- ... Four new flavone derivatives (1–4), together with six known flavones (5-10), were isolated from the stems of Dracaena angustifolia. The complete structures of new compounds were elucidated by analyses of spectroscopic data and quantum chemistry calculations. Compounds 2, 9 and 10 displayed weak anti-inflammatory activity with IC₅₀ values of 45, 33 and 61 μM, respectively. ...
- DOI:
- 10.1016/j.phytol.2020.01.025
- https://doi.org/10.1016/j.phytol.2020.01.025
- Author:
- Akram A. Shalabi; Ali M. El Halawany; Mouchira A. Choucry; Fatma S. El-Sakhawy; Hiroyuki Morita; Dae-Won Ki; Essam Abdel-Sattar
- Source:
- Phytochemistry letters 2020 v.36 pp. 49-57
- ISSN:
- 1874-3900
- Subject:
- Caralluma; acarbose; alpha-glucosidase; beta-sitosterol; enzyme inhibition; fractionation; glucosides; inhibitory concentration 50; luteolin; methylene chloride; pregnanes; triacylglycerol lipase
- Abstract:
- ... Three new pregnane glycosides in addition to four known compounds were isolated from the methylene chloride fraction of Caralluma hexagona Lavranos using bioassay-guided fractionation. The new compounds were identified as 12,20-di-O-benzoyl-3β,8β,12β,14β,20-pentahydroxy-(20R)-pregn-5-ene-3-O-β-d-glucopyranosyl-(1→4)-β-d-digitaloside (1), 3β,8β,14β,20-tetrahydroxy (20R)-pregn-5-ene-3-O-β-d-glucopyr ...
- DOI:
- 10.1016/j.phytol.2020.01.015
- https://doi.org/10.1016/j.phytol.2020.01.015
- Author:
- Dun Wang; Ya-Li Wang; Peng Zhang; Xing-Zhou Li; Hua Li; Li-Xia Chen
- Source:
- Phytochemistry letters 2020 v.35 pp. 84-87
- ISSN:
- 1874-3900
- Subject:
- Ganoderma; enantiomers; ethanol; fruiting bodies; high performance liquid chromatography; inhibitory concentration 50; macrophages; nitric oxide; nuclear magnetic resonance spectroscopy; sesquiterpenoids; spectral analysis
- Abstract:
- ... One new sesquiterpenoid, ganosinensol K (1) and one new norsesquiterpenoid, ganosinensol L (2) were isolated from 95 % EtOH extract of the fruiting bodies of Ganoderma sinense. Their structures were determined on the basis of extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR, and optical rotation value. Compound 1 should be a mixture of two enantiomers. We attempted to resolve comp ...
- DOI:
- 10.1016/j.phytol.2019.11.007
- https://doi.org/10.1016/j.phytol.2019.11.007
- Author:
- Yanjun Zhang; Huangcan Chen; Dexiong Zhou; Wei Liu; Gaorong Zhang; Lili Hao; Chenguo Li; Ruiyun Yang; Shengping Deng; Jun Li; Xishan Huang
- Source:
- Phytochemistry letters 2020 v.37 pp. 70-74
- ISSN:
- 1874-3900
- Subject:
- cytotoxicity; flavonoids; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis; stems; China
- Abstract:
- ... Phytochemical investigation of the stems of Mallotus paxii Pamp., which are used for traditional Chinese medicinal treatment of viral infections in China, led to the isolation of four new flavonoids, paxiiones, A–D (1-4). Their structures were elucidated by spectroscopic analyses, including MS, NMR (1D and 2D), X-ray, experimental CD, and calculated ECD spectra. Compounds 1-4 were evaluated for the ...
- DOI:
- 10.1016/j.phytol.2020.03.011
- https://doi.org/10.1016/j.phytol.2020.03.011
33. Protein tyrosine phosphatase 1B inhibitory triterpene glycosides from Mussaenda pilosissima Valeton
- Author:
- Vu Kim Thu; Nguyen Xuan Bach; Nguyen Thi Thu Hien; Hua Thi Son; Tran Hong Quang; Youn-Chul Kim; Hyuncheol Oh; Phan Van Kiem
- Source:
- Phytochemistry letters 2020 v.36 pp. 139-143
- ISSN:
- 1874-3900
- Subject:
- Mussaenda; chemical structure; electrospray ionization mass spectrometry; glycosides; inhibitory concentration 50; leaves; nuclear magnetic resonance spectroscopy; protein-tyrosine-phosphatase; triterpenoids
- Abstract:
- ... Three new triterpene glycosides, mussapilosides A–C (1-3) together with six known triterpene glycosides, cincholic acid-28-O-β-d-glucopyranosyl ester (4), mussaendoside S (5), quinovic acid 28-O-β-d-glucopyranosyl ester (6), glycoside A (7), glycoside B (8), and quinovic acid 3-O-β-d-glucopyranosyl(1→2)-β-d-glucopyranoside (9) were isolated from the leaves of Mussaenda pilosissima. Their chemical ...
- DOI:
- 10.1016/j.phytol.2020.01.023
- https://doi.org/10.1016/j.phytol.2020.01.023
- Author:
- Sherif S. Ebada; Weaam Ebrahim
- Source:
- Phytochemistry letters 2020 v.36 pp. 95-98
- ISSN:
- 1874-3900
- Subject:
- Penicillium simplicissimum; Staphylococcus aureus; adenocarcinoma; amino acids; antibacterial properties; antimicrobial peptides; chemical structure; chromatography; cytotoxicity; derivatization; epithelium; ethyl acetate; fungi; heterocyclic compounds; human cell lines; hypersalinity; inhibitory concentration 50; metabolites; neoplasm cells; nuclear magnetic resonance spectroscopy; refining; rice; spectral analysis
- Abstract:
- ... Chromatographic refining of the EtOAc extract of a solid rice culture of the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17 afforded a new linear antibacterial peptide quinoisobutyride A (1) along with three known metabolites (2-4). The chemical structure of 1 was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses together with HRESIMS. In add ...
- DOI:
- 10.1016/j.phytol.2020.01.022
- https://doi.org/10.1016/j.phytol.2020.01.022
- Author:
- Tomoki Iguchi; Akihito Yokosuka; Minpei Kuroda; Mayuko Takeya; Mizuki Hagiya; Yoshihiro Mimaki
- Source:
- Phytochemistry letters 2020 v.37 pp. 21-28
- ISSN:
- 1874-3900
- Subject:
- Lilium speciosum; bulbs; cytotoxicity; glycosides; human cell lines; human diseases; inhibitory concentration 50; lung neoplasms; neoplasm cells; spectral analysis
- Abstract:
- ... Steroidal glycosides (1-21), including eight new spirostanol glycosides (1-8) and a new cholestane glycoside (9), were isolated from the bulbs of Lilium speciosum. The structures of the new compounds were determined based on spectroscopic data analysis and hydrolytic cleavage reactions. The isolated compounds and their aglycones (1a, 8a, and 9a) were evaluated for their cytotoxicity against HL-60 ...
- DOI:
- 10.1016/j.phytol.2020.01.008
- https://doi.org/10.1016/j.phytol.2020.01.008
- Author:
- Georges Bellier Tabekoueng; Carine Mvot Akak; Gervais Mouthé Happi; Moses K. Langat; Marcel Frese; Hans-Georg Stammler; Beate Neumann; Anatole Guy Blaise Azebaze; Alain François Kamdem Waffo; Jean Duplex Wansi; Bruno N. Lenta; Norbert Sewald; Juliette Catherine Vardamides; Augustin E. Nkengfack
- Source:
- Phytochemistry letters 2020 v.38 pp. 12-18
- ISSN:
- 1874-3900
- Subject:
- Menispermaceae; Staphylococcus aureus; acetylation; alkaloids; allylation; antibacterial properties; carbohydrates; chemical structure; chemotaxonomy; cytotoxicity; dipeptides; diterpenoids; fatty alcohols; inhibitory concentration 50; mass spectrometry; nuclear magnetic resonance spectroscopy; phenolic compounds; phytosterols; roots; spectral analysis; ursolic acid
- Abstract:
- ... A phytochemical investigation of the roots and twigs of Penianthus zenkeri Diels led to the identification of twenty four compounds including one previously undescribed C-28 ecdysteroid (1) and previously described phytosteroids (2–5, 20, 22, 23), phenolic compounds (6–8, 12), diterpenoids (9–11), alkaloids (13,14, 18, 19), a dipeptide (15), ursane type triterpenoids (16–17), a carbohydrate (21) a ...
- DOI:
- 10.1016/j.phytol.2020.04.017
- https://doi.org/10.1016/j.phytol.2020.04.017
- Author:
- Yong-Long Wang; Zhi-Nan Xiang; Yan Yuan; Jie-Wen Zhou; Luan-Yuan Tian; Jia-Chun Chen; Luo-Sheng Wan
- Source:
- Phytochemistry letters 2020 v.36 pp. 86-90
- ISSN:
- 1874-3900
- Subject:
- Buxus; alkaloids; branches; cytotoxicity; human cell lines; in vitro studies; inhibitory concentration 50; leaves; neoplasm cells; nuclear magnetic resonance spectroscopy; phytochemicals; spectral analysis; triterpenoids
- Abstract:
- ... Phytochemical study of the twigs and leaves of Buxus rugulosa resulted in the isolation of eight triterpenoid alkaloids, including four new triterpenoid alkaloids, namely buxruguloids A–D (1–4), together with four known analogues 5–8. The structures of 1–4 were identified by the analysis of NMR and MS spectroscopic data. All the new compounds were assessed in vitro for their cytotoxic activities a ...
- DOI:
- 10.1016/j.phytol.2020.01.002
- https://doi.org/10.1016/j.phytol.2020.01.002
- Author:
- Mei Liao; Cui-fen Zeng; Fang-Ping Liang
- Source:
- Phytochemistry letters 2020 v.37 pp. 106-109
- ISSN:
- 1874-3900
- Subject:
- Arnebia euchroma; cell lines; chemical structure; chromatography; cytotoxicity; epithelial cells; ethanol; fractionation; humans; inhibitory concentration 50; lung neoplasms; naphthoquinones; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... The crude ethanol extract of the roots of Arnebia euchroma was subjected to successive chromatographic fractionation, which afforded two new dimeric naphthoquinone derivatives isovalerylalkannin dimer (1) and β-acetoxy-isovalerylalkannin dimer (2) as well as three known monomeric naphthoquinones, alkannin (3), isovalerylalkannin (4) and β-acetoxy-isovalerylalkannin (5). The chemical structures of ...
- DOI:
- 10.1016/j.phytol.2020.04.004
- https://doi.org/10.1016/j.phytol.2020.04.004
- Author:
- Si-Yuan Shao; Chao Wang; Shao-Wei Han; Shuai Li
- Source:
- Phytochemistry letters 2020 v.35 pp. 6-9
- ISSN:
- 1874-3900
- Subject:
- Pleione; breast neoplasms; cytotoxicity; human cell lines; human diseases; inhibitory concentration 50; neoplasm cells; quinones; spectral analysis; tubers
- Abstract:
- ... Two new phenanthrenequinones, bulbocodioidins I–J (1 and 2), were isolated from the tubers of Pleione bulbocodioides. They possess a 9(10)H-phenanthren-10(9)-one structure, which is relatively rare from natural sources. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of them were determined by comparison of the experimental and calculated ECD ...
- DOI:
- 10.1016/j.phytol.2019.10.006
- https://doi.org/10.1016/j.phytol.2019.10.006
- Author:
- Si-Si Liu; Ju-Xing Jiang; Rong Huang; Ya-Ting Wang; Bo-Guang Jiang; Kai-Xuan Zheng; Shao-Hua Wu
- Source:
- Phytochemistry letters 2019 v.29 pp. 75-78
- ISSN:
- 1874-3900
- Subject:
- Aconitum vilmorinianum; Influenza A virus; Phoma; alcohols; antiviral properties; culture media; endophytes; fungi; inhibitory concentration 50; roots; sesquiterpenoids; spectral analysis
- Abstract:
- ... A new rare 14-nordrimane-type sesquiterpenoid, named phomanolide (1), together with five known compounds, (–)-6-methoxymellein (2), 7-hydroxy-3, 5-dimethyl-isochromen-1-one (3), norlichexanthone (4), 6-methylsalicylic acid (5), and gentisyl alcohol (6), were obtained from the culture broth of an endophytic fungus Phoma sp. isolated from the roots of Aconitum vilmorinianum. The structure of compoun ...
- DOI:
- 10.1016/j.phytol.2018.11.005
- https://doi.org/10.1016/j.phytol.2018.11.005
41. A new chlorinated diphenyl ether and a new sesquilignan from the stems of Mappianthus tomentosus
- Author:
- Shan-Shan Zhu; Gui-Jie Zhang; Hai-Bing Liao; Heng-Shan Wang; Dong Liang
- Source:
- Phytochemistry letters 2019 v.30 pp. 49-52
- ISSN:
- 1874-3900
- Subject:
- diphenyl ethers; inhibitory concentration 50; lipopolysaccharides; neuroglia; nitric oxide; spectral analysis; stems
- Abstract:
- ... A new chlorinated diphenyl ether, ethyl dichloroasterrate (1), and a new sesquilignan, mappilignan A (2), along with two known diphenyl ethers (3 and 4) and one known sesquilignan (5), were isolated from the stems of Mappianthus tomentosus. The structures of 1−5 were assigned by spectroscopic data analysis and by comparison with literature data. The absolute configuration of 2 was established usin ...
- DOI:
- 10.1016/j.phytol.2019.01.018
- https://doi.org/10.1016/j.phytol.2019.01.018
42. A phenanthroindolizidine glycoside with HIF-1 inhibitory activity from Tylophora atrofolliculata
- Author:
- Cheng-Yu Chen; Guo-Yuan Zhu; Tang-Gui Xie; Ping-Chuan Jiang; Jing-Rong Wang; Zhi-Hong Jiang
- Source:
- Phytochemistry letters 2019 v.31 pp. 39-42
- ISSN:
- 1874-3900
- Subject:
- Tylophora; alkaloids; cytotoxicity; glucosylation; glycosides; hypoxia-inducible factor 1; inhibitory concentration 50; neoplasm cells
- Abstract:
- ... A phenanthroindolizidine glycoside 6-O-β-D-glucopyranosyl-tylophorinidine (1), the first glycoside of phenanthroindolizidine alkaloid in nature, was isolated from whole plants of Tylophora atrofolliculata (Asclepiadaceae). Its structure was elucidated by means of spectral and chemical evidences. Compound 1 showed potent inhibitory effect (IC50: 69 ± 13 nM) on hypoxia induced factor-1 (HIF-1) activ ...
- DOI:
- 10.1016/j.phytol.2019.03.003
- https://doi.org/10.1016/j.phytol.2019.03.003
- Author:
- Nguyen Thi Hong Van; Tran Thi Tuyen; Pham Minh Quan; Pham Quoc Long; Nguyen Xuan Nhiem; Bui Huu Tai; Cam Thi Inh; Vu Dinh Hoang; Phan Van Kiem; Chau Van Minh; SeonJu Park; Seung Hyun Kim
- Source:
- Phytochemistry letters 2019 v.32 pp. 47-51
- ISSN:
- 1874-3900
- Subject:
- Zanthoxylum nitidum; alkaloids; branches; cytotoxicity; glycosides; human cell lines; humans; inhibitory concentration 50; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy
- Abstract:
- ... Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human ...
- DOI:
- 10.1016/j.phytol.2019.04.022
- https://doi.org/10.1016/j.phytol.2019.04.022
44. Analysis of chemical constituents from Polygonatum cyrtonema after “Nine-Steam-Nine-Bask” processing
- Author:
- Wen-Xiang Wang; Xian Zhang; Xi-La-Tu Dabu; Juan He; Sheng-Chao Yang; Jun-Wen Chen; Wei Fan; Guang-Hui Zhang; Hong-Lian Ai; Mei-Rong Hai
- Source:
- Phytochemistry letters 2019 v.29 pp. 35-40
- ISSN:
- 1874-3900
- Subject:
- Polygonatum cyrtonema; anti-inflammatory activity; chemical composition; glucose; inhibitory concentration 50; nitric oxide; spectral analysis
- Abstract:
- ... Seven new compounds, known as polygonatine N1‒N7 (1‒7), and a known compound (8) were isolated from the ‘Nine-Steam-Nine-Bask’ processing product of Polygonatum cyrtonema Hua. The compounds’ structures were determined by spectroscopic analysis. All compounds were tested for dipeptidyl peptidase-4 (DPP-4) inhibition, glucose transport, and anti-inflammatory activities. Compound 8 suppressed NO prod ...
- DOI:
- 10.1016/j.phytol.2018.11.004
- https://doi.org/10.1016/j.phytol.2018.11.004
- Author:
- Xianming Su; Jian Zhang; Fenghua Li; Changkang Li; Jia Fu; Baoming Li; Ruoyun Chen; Jie Kang
- Source:
- Phytochemistry letters 2019 v.33 pp. 55-60
- ISSN:
- 1874-3900
- Subject:
- 2,5-dihydroxybenzoic acid; Croton; Morinda; aerial parts; anti-inflammatory activity; benzoic acid; ears; edema; ethyl acetate; gene expression; glycosides; herbal medicines; indigestion; inhibitory concentration 50; interleukin-6; mice; oils; spectral analysis; tracheitis
- Abstract:
- ... The plant Morinda parvifolia is traditionally used as an herbal medicine for the treatment of dyspepsia, tracheitis, and coughing. The ethyl acetate extract of the aerial parts of M. parvifolia showed significant inhibition against ear edema in mice induced by croton oil (36.4% inhibition). Four undescribed glycosides, 2-hydroxymethyl anthraquinone-3-O-β-primeveroside, p-hydroxy benzoic acid 4-O-β ...
- DOI:
- 10.1016/j.phytol.2019.07.008
- https://doi.org/10.1016/j.phytol.2019.07.008
- Author:
- Maan T. Khayat; Sabrin R.M. Ibrahim; Gamal A. Mohamed; Hossam M. Abdallah
- Source:
- Phytochemistry letters 2019 v.29 pp. 104-109
- ISSN:
- 1874-3900
- Subject:
- Fusarium; Mentha longifolia; endophytes; ergosterol; fungi; indomethacin; inhibitory concentration 50; mass spectrometry; metabolites; nuclear magnetic resonance spectroscopy; oxygenases; roots; structure-activity relationships; Saudi Arabia
- Abstract:
- ... Three new ergosterol derivatives, namely, fusaristerols B [(22E,24R)-3-palmitoyl-19(10→6)-abeo-ergosta-5,7,9,22-tetraen-3β-ol] (1), C [(22E,24R)-ergosta-7,22-diene-3β,6β,9α-triol] (3), and D [(22E,24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol 6-acetate] (4), along with (22E,24R)-5β,8β-epidioxyergosta-22-en-3β-yl decanoate (2) and (22E,24R)-ergosta-7,22-dien-3β-ol (5), were isolated and characterized ...
- DOI:
- 10.1016/j.phytol.2018.11.024
- https://doi.org/10.1016/j.phytol.2018.11.024
- Author:
- Emmy Tuenter; Yancho Zarev; An Matheeussen; Esameldin Elgorashi; Luc Pieters; Kenn Foubert
- Source:
- Phytochemistry letters 2019 pp. -
- ISSN:
- 1874-3900
- Subject:
- Erythrina; Plasmodium falciparum; antimalarials; antiplasmodial properties; bark; cytotoxicity; flavonoids; inhibitory concentration 50; stems; South Africa
- Abstract:
- ... The antiplasmodial activity against Plasmodium falciparum strain K1 as well as cytotoxicity against MRC-5 cells of 15 prenylated flavonoids obtained from Erythrina latissima E. Mey (Leguminosae) from South Africa was determined. Although initially some promising activities were observed, with 5’-prenyl-pratensein being the most selective compound, most IC50 values varied from 1 to 30 µM, with cyto ...
- DOI:
- 10.1016/j.phytol.2019.02.001
- https://doi.org/10.1016/j.phytol.2019.02.001
- Author:
- Zhi-Ying Sun; Sheng-Qi Zuo; Xia Yang; Jia-Hui Lan; Cheng-Xiong Liu; Zhi-Yong Guo; Fan Cheng; Kun Zou
- Source:
- Phytochemistry letters 2019 v.34 pp. 68-73
- ISSN:
- 1874-3900
- Subject:
- Aspidistra elatior; anti-inflammatory activity; in vitro studies; inhibitory concentration 50; macrophages; nitric oxide; oxidation; rhizomes; spectral analysis; steroid saponins
- Abstract:
- ... Four new furostanol saponins, named aspidsaponins E-H (1–4) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined based on chemical methods and spectral data. Compounds 1 and 2 were a pair of diastereoisomeric furostanol saponins and possessed the highly oxidized structural feature of 1β, 2β, 3β, 4β, 5β, 26-hexanol-steroids, and compounds 3-4 were steroidal ...
- DOI:
- 10.1016/j.phytol.2019.09.014
- https://doi.org/10.1016/j.phytol.2019.09.014
- Author:
- Samuel Magloire Bissim; Sidonie Béatrice Kenmogne; Alain Tadjong Tcho; Mehreen Lateef; Ayaz Ahmed; Emmanuel Ngeufa Happi; Jean Duplex Wansi; Muhammad Shaiq Ali; Alain François Kamdem Waffo
- Source:
- Phytochemistry letters 2019 v.29 pp. 148-153
- ISSN:
- 1874-3900
- Subject:
- Citrus aurantium; acetylation; alkaloids; antioxidant activity; beta-sitosterol; bioassays; butylated hydroxyanisole; cisplatin; cytotoxicity; electrospray ionization mass spectrometry; enzyme inhibition; human cell lines; humans; inhibitory concentration 50; limonin; lung neoplasms; lupeol; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis; stigmasterol; thiourea; urease
- Abstract:
- ... Phytochemical studies on Citrus aurantium led to the isolation and characterization of a new secotirucallane, namely 1β-hydroxy-3,4-secotirucalla-4(28)-7,24-trien-3,21-dioic acid (1), together with the previously reported compounds citracridone I (2), citruisinine II (3), citracridone II (4), 5-hydroxynoracronycine (5), citpressine II (6), citpressine I (7), buntamine (8), 8-hydroxy-6-methoxy-3-pe ...
- DOI:
- 10.1016/j.phytol.2018.12.010
- https://doi.org/10.1016/j.phytol.2018.12.010
- Author:
- Qian-qian Wang; Biao Zhou; Yuan-yuan Ji; Hao-jian Zhang; Zhong-jun Ma; Li Shen; Wan-jing Ding
- Source:
- Phytochemistry letters 2019 pp. -
- ISSN:
- 1874-3900
- Subject:
- Streptomyces; anthracyclines; circular dichroism spectroscopy; cytotoxicity; density functional theory; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; spectral analysis
- Abstract:
- ... Six new anthracyclines (1-6) were obtained by the investigation of the solid fermented extract of a marine-derived Streptomyces sp. NB-A13. The structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, HRESIMS, UV and IR. The absolute configurations of compounds 1-5 were established by calculated electronic circular dichroism (ECD) using time dependent density fun ...
- DOI:
- 10.1016/j.phytol.2019.01.031
- https://doi.org/10.1016/j.phytol.2019.01.031