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- Xu, Zhaohui; Gu, Chenchen; Wang, Kai; Ju, Jiaxing; Wang, Haiying; Ruan, Kefeng; Feng, Yi
- Phytomedicine 2015 v.22 pp. 128-137
- Arctium lappa, etc ; acute toxicity; animal models; blood glucose; blood serum; body weight; dietary exposure; glucose tolerance; glycemic effect; glycosylation; hemoglobin; high performance liquid chromatography; humans; insulin secretion; lignans; metabolites; mice; noninsulin-dependent diabetes mellitus; oral administration; rats; Show all 20 Subjects
- ... We have reported the antidiabetic activity of the total lignans from Fructus arctii (TLFA) against alloxan-induced diabetes in mice and rats. In this study, arctigenic acid was found to be the main metabolite in rat plasma detected by UPLC/MS and HPLC/MS/MS after oral administration of TLFA. For the first time, its hypoglycemic activity and acute oral toxicity were evaluated in Goto-Kakizaki (GK) ...