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- Matsui, Nobuaki; Akae, Haruka; Hirashima, Nana; Kido, Yuki; Tanabe, Satoshi; Koseki, Mayumi; Fukuyama, Yoshiyasu; Akagi, Masaaki
- Phytotherapy research 2016 v.30 no.11 pp. 1856-1861
- Magnolia officinalis, etc ; Western blotting; animal models; antidepressants; magnolol; mice; mitogen-activated protein kinase; neurogenesis; neurons; neurotrophins; non-specific serine/threonine protein kinase; phosphorylation; signal transduction; tail suspension test; Show all 14 Subjects
- ... Magnolol is the main constituent of Magnolia bark and has been reported to exhibit antidepressant effects in rodent models. Hippocampal neurogenesis and neurotrophins such as brain‐derived neurotrophic factor are integrally involved in the action of conventional antidepressants. Here, we investigated the effects of magnolol on depressive behaviours, impaired hippocampal neurogenesis and neurotroph ...