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- Matsui, Nobuaki; Akae, Haruka; Hirashima, Nana; Kido, Yuki; Tanabe, Satoshi; Koseki, Mayumi; Fukuyama, Yoshiyasu; Akagi, Masaaki
- Phytotherapy research 2016 v.30 no.11 pp. 1856-1861
- Magnolia officinalis, etc ; Western blotting; animal models; antidepressants; magnolol; mice; mitogen-activated protein kinase; neurogenesis; neurons; neurotrophins; non-specific serine/threonine protein kinase; phosphorylation; signal transduction; tail suspension test; Show all 14 Subjects
- ... Magnolol is the main constituent of Magnolia bark and has been reported to exhibit antidepressant effects in rodent models. Hippocampal neurogenesis and neurotrophins such as brain‐derived neurotrophic factor are integrally involved in the action of conventional antidepressants. Here, we investigated the effects of magnolol on depressive behaviours, impaired hippocampal neurogenesis and neurotroph ...
- Kang, Jong Soon; Lee, Ki Hoon; Han, Mi Hwa; Lee, Hyunju; Ahn, Ji‐Mi; Han, Sang‐Bae; Han, Gyoonhee; Lee, Kiho; Park, Song‐Kyu; Kim, Hwan Mook
- Phytotherapy research 2008 v.22 no.7 pp. 883-888
- Magnolia kobus, etc ; DNA; anti-inflammatory activity; bark; ears; gene expression; inflammation; lipopolysaccharides; messenger RNA; mice; mitogen-activated protein kinase; models; necrosis; nitric oxide; nitric oxide synthase; phosphorylation; secretion; topical application; Show all 18 Subjects
- ... The present study reports the antiinflammatory activity of a methanol extract isolated from the stem bark of Magnolia kobus (MK). MK potently inhibited lipopolysaccharide (LPS)‐induced production of nitric oxide and interleukin‐1β (IL‐1β) in RAW 264.7 cells, a murine macrophage‐like cell line. The secretion of tumor necrosis factor‐α (TNF‐α) was also suppressed in LPS‐stimulated RAW 264.7 cells al ...