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1. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats

Author:
Zhang, Yan,   et al.   ; Qi, Zhigang; Xue, Jie; Wang, Hengbin; Xie, Meilin;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.3 pp. 231-235
ISSN:
0032-0943
Subject:
adiponectin; agonists; animal models; blood glucose; blood serum; cholesterol; fasting; fatty liver; free fatty acids; homeostasis; inflammation; insulin; insulin resistance; liver; rats; triacylglycerols; weight gain
Abstract:
... The objectives of this study were to determine the effect of osthole on the insulin resistance (IR) in high-fat and high-sucrose-induced fatty liver rats and to investigate its potential mechanisms. The rat model was established by orally feeding high-fat and high-sucrose emulsion by gavage for 9 weeks. The experimental rats were treated with osthole 5 and 10 mg/kg, lipanthyl 30 mg/kg, and rosigli ...
DOI:
10.1055/s-0030-1250268
PubMed:
20717873