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You searched for: Journal Planta medica Remove constraint Journal: Planta medica Subject Piper methysticum Remove constraint Subject: Piper methysticum Subject cytochrome P-450 Remove constraint Subject: cytochrome P-450
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1. Re-introduction of kava (Piper methysticum) to the EU: Is there a way forward?

Author:
Sarris, Jerome; Teschke, Rolf; Stough, Con; Scholey, Andrew; Schweitzer, Isaac
Source:
Planta medica 2011 v.77 no.2 pp. 107-110
ISSN:
0032-0943
Subject:
European Union; Piper methysticum; adverse effects; anxiety; bark; chemotypes; cognition; cultivars; cytochrome P-450; drug therapy; gamma-aminobutyric acid; hepatotoxicity; kava; leaves; liver function; markets; patients; people; Europe; Pacific Ocean Islands
Abstract:
... Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such as leaves or bark); thus both the plant chemotype and the plant part used may be c ...
DOI:
10.1055/s-0030-1250290
PubMed:
20814850

2. Kava does not display metabolic toxicity in a homogeneous cellular assay

Author:
Zou, L.; Harkey, M.R.; Henderson, G.L.; Dike, L.E.
Source:
Planta medica 2004 v.70 no.4 pp. 289-292
ISSN:
0032-0943
Subject:
Piper methysticum; kava; stimulant plants; phytochemicals; lactones; pyrans; pyrones; human health; humans; cell lines; cytotoxicity; biochemical pathways; cytochrome P-450; epoxide hydrolase
DOI:
10.1055/s-2004-818937
PubMed:
15095141

3. Kava hepatotoxicity: Are we any closer to the truth?

Author:
Anke, J.; Ramzan, I.
Source:
Planta medica 2004 v.70 no.3 pp. 193-196
ISSN:
0032-0943
Subject:
herbs; Piper methysticum; alkaloids; glutathione; ethanol; human health; liver failure; cytochrome P-450; kava; stimulant plants; metabolites; hepatotoxicity
DOI:
10.1055/s-2004-815533
PubMed:
15114493

4. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava)

Author:
Unger, M.; Holzgrabe, U.; Jacobsen, W.; Cummins, C.; Benet, L.Z.
Source:
Planta medica 2002 v.68 no.12 pp. 1055-1058
ISSN:
0032-0943
Subject:
Piper methysticum; fractionation; lactones; complementary DNA; plant extracts; bioassays; cytochrome P-450; rhizomes; chemical structure; herbal medicines
DOI:
10.1055/s-2002-36360
PubMed:
12494328