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1. Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats

Author:
Zhang, Xin; Zhang, Chunfeng,   et al.   ; Chen, Lvyi; Lan, Zhou; Zhou, Yongqiang; Li, Fei; Yang, Zhonglin; Li, Ping;     Show all 8 Authors
Source:
Planta medica 2011 v.77 no.16 pp. 1769-1773
ISSN:
0032-0943
Subject:
Smilax china; blood serum; creatinine; drugs; excretion; flavonoids; hyperuricemia; interleukin-1; kidney diseases; prostaglandins; rats; renal function; transforming growth factor beta 1; urea nitrogen; uric acid; xanthine oxidase
Abstract:
... Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L. The effects and possible mechanisms of astilbin on hyperuricemia and nephropathy rats were elucidated in this study. Different dosages of astilbin (1.25, 2.5, and 5.0 mg/kg) were administered to 10 % fructose-induced hyperuricemic rats. The results demonstrated that astilbin significantly decreased the serum uric acid (S ...
DOI:
10.1055/s-0030-1271135
PubMed:
21614752

2. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats

Author:
Zhang, Yan,   et al.   ; Qi, Zhigang; Xue, Jie; Wang, Hengbin; Xie, Meilin;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.3 pp. 231-235
ISSN:
0032-0943
Subject:
adiponectin; agonists; animal models; blood glucose; blood serum; cholesterol; fasting; fatty liver; free fatty acids; homeostasis; inflammation; insulin; insulin resistance; liver; rats; triacylglycerols; weight gain
Abstract:
... The objectives of this study were to determine the effect of osthole on the insulin resistance (IR) in high-fat and high-sucrose-induced fatty liver rats and to investigate its potential mechanisms. The rat model was established by orally feeding high-fat and high-sucrose emulsion by gavage for 9 weeks. The experimental rats were treated with osthole 5 and 10 mg/kg, lipanthyl 30 mg/kg, and rosigli ...
DOI:
10.1055/s-0030-1250268
PubMed:
20717873

3. Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits

Author:
Zhang, Yuqin; Zhang, Ling,   et al.   ; Shao, Meng; Qu, Kai; Liu, Ke; Lian, Zeqin; Chen, Tingting; Liu, Junfeng; Wu, Aili; Tang, Yue; Zhu, Haibo;     Show all 11 Authors
Source:
Planta medica 2011 v.77 no.8 pp. 809-816
ISSN:
0032-0943
Subject:
alanine transaminase; alkaline phosphatase; aspartate transaminase; bilirubin; biomarkers; blood serum; creatinine; dexamethasone; heart; heart rate; histopathology; interleukin-1beta; intravenous injection; kidneys; lactate dehydrogenase; lipopolysaccharides; liver; lungs; necrosis; nitric oxide; protective effect; rabbits; radioimmunoassays; temperature; tumor necrosis factor-alpha; urea nitrogen
Abstract:
... In this study, we investigated the protective effects of ligustilide against lipopolysaccharide (LPS)-induced endotoxic shock in Japanese white rabbits and attempted to elucidate the possible mechanism underlying these effects. Forty-two rabbits were randomized into 6 groups: normal group, LPS group, dexamethasone group (5 mg/kg), and 3 ligustilide groups (20, 40, and 80 mg/kg). After the rabbits ...
DOI:
10.1055/s-0030-1250573
PubMed:
21104607

4. Effects of fucoidan on chronic renal failure in rats

Author:
Zhang, Q.B.; Zhang, H.,   et al.   ; Li, Z.; Xu, Z.H.; Niu, X.Z.;     Show all 5 Authors
Source:
Planta medica 2003 v.69 no.6 pp. 537-541
ISSN:
0032-0943
Subject:
albumins; renal failure; blood serum; creatine; phytochemicals; algae; protein content; body weight; fucoidan; medicinal plants; disease control; animal models; Laminaria; kidneys; urea nitrogen; histopathology; rats
DOI:
10.1055/s-2003-40634
PubMed:
12865973

5. Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase

Author:
Zhang, Qian,   et al.   ; Zhou, Dan-yang; Du, Qiang; Li, Ruo-ran; Huang, Mao; Wei, Guo-zhen;     Show all 6 Authors
Source:
Planta medica 2011 v.77 no.14 pp. 1575-1581
ISSN:
0032-0943
Subject:
animal models; antioxidants; asthma; blood serum; goblet cells; grape seeds; immunoglobulin E; inducible nitric oxide synthase; inflammation; interferons; interleukin-13; mice; nitric oxide; ovalbumin
Abstract:
... Allergic asthma is characterized by hyperresponsiveness and inflammation of the airway with increased expression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide (NO). Grape seed proanthocyanidin extract (GSPE) has been proved to have antioxidant, antitumor, anti-inflammatory, and other pharmacological effects. The purpose of this study was to examine the role of GSPE o ...
DOI:
10.1055/s-0030-1270957
PubMed:
21452107

6. Coumarin Glycosides and Iridoid Glucosides with Neuroprotective Effects from Hydrangea paniculata

Author:
Zhang, Dong-Ming,   et al.   ; Shi, Jing; Li, Chuang-Jun; Yang, Jing-Zhi; Yuan, Yu-He; Chen, Nai-Hong;     Show all 6 Authors
Source:
Planta medica 2012 v.78 no.17 pp. 1844-1850
ISSN:
0032-0943
Subject:
Hydrangea paniculata; blood serum; chemical analysis; coumarin; loganin; neuroprotective effect; spectroscopy; stems; umbelliferones
Abstract:
... Five new coumarin glycosides, umbelliferone 7-O-sophoroside (1), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-β-D-glucopyranoside (2), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-[β-D-apiofuranosyl(1 → 6)]-β-D-glucopyranoside (3), umbelliferone 7-O-β-D-glucopyranosyl(1 → 2)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (4), and umbelliferone 7-O-β-D-glucopyranosyl(1 → 5)-β-D-apiofuranosyl(1 → 6)-β-D ...
DOI:
10.1055/s-0032-1315394
PubMed:
23047248

7. Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression

Author:
Zhang, Y.,   et al.   ; Xie, M.; Xue, J.; Gu, Z.;     Show all 4 Authors
Source:
Planta medica 2007 v.73 no.8 pp. 718-724
ISSN:
0032-0943
Subject:
fatty liver; transcription factors; hepatocytes; diacylglycerol acyltransferase; liver; blood serum; hyperlipidemia; fatty acid-binding proteins; gene expression regulation; triacylglycerols; human health; cholesterol; cytochrome P-450; coumarins; rats; receptors; Cnidium; animal disease models
DOI:
10.1055/s-2007-981552
PubMed:
17611927

8. Mulberroside A possesses potent uricosuric and nephroprotective effects in hyperuricemic mice

Author:
Zhang, Xian,   et al.   ; Wang, Cai-Ping; Wang, Yemin; Wang, Xing; Ye, Jian-Feng; Hu, Lin-Shui; Kong, Ling-Don;     Show all 7 Authors
Source:
Planta medica 2011 v.77 no.8 pp. 786-794
ISSN:
0032-0943
Subject:
Morus alba; Oriental traditional medicine; albumins; beta-N-acetylhexosaminidase; blood serum; carnitine; creatinine; drugs; excretion; gene expression regulation; glucose transporters; glycosides; gout; hyperuricemia; messenger RNA; mice; urea nitrogen; uric acid
Abstract:
... Mulberroside A is a major stilbene glycoside of Morus alba L. (Moraceae), which is effectively used for the treatment of hyperuricemia and gout in traditional Chinese medicine. We examined whether mulberroside A had effects on renal urate underexcretion and dysfunction in oxonate-induced hyperuricemic mice and investigated the potential uricosuric and nephroprotective mechanisms involved. Mulberro ...
DOI:
10.1055/s-0030-1250599
PubMed:
21154198

9. Crocetin prevents dexamethasone-induced insulin resistance in rats

Author:
Zhang, Y.,   et al.   ; Xi, L.; Qian, Z.; Shen, X.; Wen, N.;     Show all 5 Authors
Source:
Planta medica 2005 v.71 no.10 pp. 917-922
ISSN:
0032-0943
Subject:
plant biochemistry; blood serum; Gardenia jasminoides; blood glucose; plant extracts; insulin resistance; carotenoids; insulin; rats; dexamethasone; glucose tolerance
DOI:
10.1055/s-2005-871248
PubMed:
16254822

10. Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis

Author:
Zhang, W.,   et al.   ; Lu, C.; Liu, Z.; Yang, D.; Chen, S.; Cha, A.; Wu, Z.; Lu, A.;     Show all 8 Authors
Source:
Planta medica 2007 v.73 no.4 pp. 336-340
ISSN:
0032-0943
Subject:
immunoglobulin G; blood serum; Tripterygium wilfordii; phenanthrenes; phytochemicals; glycyrrhizin; medicinal plants; Oriental traditional medicine; human health; tumor necrosis factor-alpha; diterpenoids; interleukin-10; animal disease models; rheumatoid arthritis
DOI:
10.1055/s-2007-967136
PubMed:
17354165