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1. Taraxasterane-Type Triterpene and Neolignans from Geum japonicum Thunb. var. chinense F. Bolle

Author:
Zhang, Shoude; Zhang, Fei; Zhang, Weidong,   et al.   ; Cheng, Xiangrong; Qin, Jiangjiang; Zeng, Qi; Yan, Shikai; Jin, Huizi;     Show all 8 Authors
Source:
Planta medica 2011 v.77 no.18 pp. 2061-2065
ISSN:
0032-0943
Subject:
Geum; anti-inflammatory activity; lignans; macrophages; nitric oxide; nuclear magnetic resonance spectroscopy; triterpenoids
Abstract:
... The phytochemical investigation of the ethanolic extract of the whole plants of Geum japonicum Thunb. var. chinense F. Bolle yielded four new compounds: 20beta,28-epoxy-28-hydroxytaraxasteran-3beta-ol1),(7R,8R)-4-hydroxy-9'-O-(alpha-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (2), (7R,8S)-4-hydroxy-9'-O-(alpha-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (3), and (7S,8S)-5-met ...
DOI:
10.1055/s-0031-1280091
PubMed:
21800281

2. Flavonoids from the Roots of Campylotropis hirtella

Author:
Zhang, Sheng,   et al.   ; Tan, Qing; Shen, Zhengwu;     Show all 3 Authors
Source:
Planta medica 2011 v.77 no.16 pp. 1811-1817
ISSN:
0032-0943
Subject:
flavanones; roots; spectroscopy
Abstract:
... Eight new flavonoids, including three pterocarpene derivatives, hirtellanines C-E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H-J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated th ...
DOI:
10.1055/s-0030-1271185
PubMed:
21678233

3. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro

Author:
Zhang, S.M.; Zhang, L.; Zhang, K.P.,   et al.   ; Zeng, X.H.; Zheng, X.X.;     Show all 5 Authors
Source:
Planta medica 2006 v.72 no.15 pp. 1359-1365
ISSN:
0032-0943
Subject:
neuroprotective effect; ischemia; animal disease models; medicinal plants; Gastrodia elata; human health; glucosides; rats; benzyl alcohol; Oriental traditional medicine; phenolic compounds
DOI:
10.1055/s-2006-951709
PubMed:
17089323

4. Flavone C-glycosides from the Leaves of Lophatherum gracile and Their In Vitro Antiviral Activity

Author:
Zhang, Jing; Zhang, Xiao-Li; Zhang, Qing-Wen,   et al.   ; Wang, Ying; Chen, Mei; Huang, Xiao-Jun; Wu, Xin; Li, Yao-Lan; Ye, Wen-Cai;     Show all 9 Authors
Source:
Planta medica 2012 v.78 no.1 pp. 46-51
ISSN:
0032-0943
Subject:
acid hydrolysis; antiviral properties; apigenin; cytopathogenicity; glycosides; leaves; luteolin; spectroscopy; viruses
Abstract:
... Four new flavone C-glycosides, luteolin 6-C-alpha-L-arabinopyranosyl-7-O-beta-D-glucopyranoside (1), apigenin 6-C-beta-D-galactopyranosiduronic acid (1 to 2)-alpha-L-arabinopyranoside (2), luteolin 6-C-beta-D-galactopyranosiduronic acid (1 to 2)-alpha-L-arabinopyranoside (3), and luteolin 6-C-beta-D-glucopyranosiduronic acid (1 to 2)-alpha-L-arabinofuranoside (4), along with three known ones, were ...
DOI:
10.1055/s-0031-1280128
PubMed:
21870321

5. Antitumor Activity of Taspine by Modulating the EGFR Signaling Pathway of Erk1/2 and Akt In Vitro and In Vivo

Author:
Zhang, Yanmin; Zhang, Jie,   et al.   ; Zheng, Lei; Dai, Bingling; Wang, Nan; Chen, Yinnan; He, Langchong;     Show all 7 Authors
Source:
Planta medica 2011 v.77 no.16 pp. 1774-1781
ISSN:
0032-0943
Subject:
Western blotting; angiogenesis; anticarcinogenic activity; cell movement; cell proliferation; drugs; enzyme-linked immunosorbent assay; humans; mice; mitogen-activated protein kinase; neoplasms; phosphorylation; proteins; quantitative polymerase chain reaction; secretion; signal transduction
Abstract:
... EGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expression of key signaling molecules of EGFR (EGFR, Akt, p-Akt, Erk, and p-Erk) by We ...
DOI:
10.1055/s-0030-1271132
PubMed:
21614750

6. Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats

Author:
Zhang, Xin; Zhang, Chunfeng,   et al.   ; Chen, Lvyi; Lan, Zhou; Zhou, Yongqiang; Li, Fei; Yang, Zhonglin; Li, Ping;     Show all 8 Authors
Source:
Planta medica 2011 v.77 no.16 pp. 1769-1773
ISSN:
0032-0943
Subject:
Smilax china; blood serum; creatinine; drugs; excretion; flavonoids; hyperuricemia; interleukin-1; kidney diseases; prostaglandins; rats; renal function; transforming growth factor beta 1; urea nitrogen; uric acid; xanthine oxidase
Abstract:
... Astilbin is a flavonoid compound isolated from the rhizome of Smilax china L. The effects and possible mechanisms of astilbin on hyperuricemia and nephropathy rats were elucidated in this study. Different dosages of astilbin (1.25, 2.5, and 5.0 mg/kg) were administered to 10 % fructose-induced hyperuricemic rats. The results demonstrated that astilbin significantly decreased the serum uric acid (S ...
DOI:
10.1055/s-0030-1271135
PubMed:
21614752

7. New Phenylpropanoids and In Vitro α-Glucosidase Inhibitors from Balanophora japonica

Author:
Zhang, Xiao-hui; Zhang, Shu-wei,   et al.   ; Zhou, Tong; Liu, Shan-shan; Xuan, Li-jiang;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.5 pp. 477-481
ISSN:
0032-0943
Subject:
Balanophora; alpha-glucosidase; inhibitory concentration 50; phenylpropanoids; tannins
Abstract:
... Five new phenylpropanoids, named balajaponins A-E (1-5), were isolated from Balanophora japonica, along with 24 known compounds. Among them, three hydrolysable tannins (6-8) showed specific in vitro α-glucosidase inhibition, with IC50 values in the range of 1-4 µM. Kinetic analysis revealed that they all acted in a noncompetitive mode. ...
DOI:
10.1055/s-0030-1250464
PubMed:
20979022

8. Three New Terpenoid Indole Alkaloids from Catharanthus roseus

Author:
Zhang, Yu; Zhang, Qiang,   et al.   ; Wang, Lei; He, Hong-Ping; Li, Shi-Fei; Hao, Xiao-Jiang;     Show all 6 Authors
Source:
Planta medica 2011 v.77 no.7 pp. 754-758
ISSN:
0032-0943
Subject:
Catharanthus roseus; cytotoxicity; indole alkaloids; nuclear magnetic resonance spectroscopy; terpenoids
Abstract:
... Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR). Cytotoxic activities of these isolates (1-10) were evaluated, but only compound 8 was active against HL-60, SMMC-77 ...
DOI:
10.1055/s-0030-1250569
PubMed:
21104604

9. Ardeemins and Cytochalasins from Aspergillus terreus Residing in Artemisia annua

Author:
Zhang, Hua-Wei; Zhang, Jie; Zhang, Zun-Jian,   et al.   ; Hu, Sha; Zhu, Cheng-Jian; Ng, Seik Weng; Tan, Ren-Xiang;     Show all 7 Authors
Source:
Planta medica 2010 v.76 no.14 pp. 1616-1621
ISSN:
0032-0943
Subject:
Aspergillus terreus; medicinal plants; hyphae; chemical constituents of plants; alkaloids; quantitative analysis; chemical structure; plant extracts; medicinal properties; cytotoxicity; human cell lines; nasopharynx; neoplasms; dose response; endophytes; Artemisia annua; China
DOI:
10.1055/s-0030-1249781

10. Identification and Comparison of Metabolites After Oral Administration of Essential Oil of Ligusticum chuanxiong or its Major Constituent Ligustilide in Rats

Author:
Zhang, Yinghao; Zhang, Jinlan,   et al.   ; Ding, Chunguang; Sheng, Yuxin; Du, Guanhua;     Show all 5 Authors
Source:
Planta medica 2008 v.74 no.14 pp. 1684-1692
ISSN:
0032-0943
Subject:
Ligusticum; medicinal plants; Oriental traditional medicine; essential oils; lactones; oral administration; rats; urine; feces; bile; human health
DOI:
10.1055/s-0028-1088309

11. Quantitative Determination of Decursin, Decursinol Angelate, and Decursinol in Mouse Plasma and Tumor Tissue Using Liquid-Liquid Extraction and HPLC

Author:
Zhang, Jinhui; Zhang, Yong,   et al.   ; Li, Li; Shaik, Ahmad Ali; Wang, Lei; Xing, Chengguo; Kim, Sung-Hoon; Lu, Junxuan;     Show all 8 Authors
Source:
Planta medica 2012 v.78 no.3 pp. 252-259
ISSN:
0032-0943
Subject:
Angelica gigas; animal experimentation; animal models; anticarcinogenic activity; ethanol; ethyl acetate; high performance liquid chromatography; hydrolysis; hydrophobicity; intraperitoneal injection; isomers; liquid-liquid extraction; medicinal plants; metabolites; mice; pharmacokinetics; phytochemicals; quantitative analysis; rats
Abstract:
... The pyranocoumarin compound decursin and its isomer decursinol angelate (DA) are the major hydrophobic phytochemicals in the root of Angelica gigas Nakai (AGN, Korean Angelica), a major traditional medicinal herb. The ethanol extract of AGN and especially the purified decursin and DA have been shown to exhibit antitumor activities by our collaborative team and others. Although decursinol has been ...
DOI:
10.1055/s-0031-1280384
PubMed:
22116603

12. Six new triterpenoid saponins from the root and stem bark of Cephalanthus occidentalis

Author:
Zhang, Z.; Zhang, S.,   et al.   ; Li, S.;     Show all 3 Author
Source:
Planta medica 2005 v.71 no.4 pp. 355-361
ISSN:
0032-0943
Subject:
Cephalanthus occidentalis; wetland plants; roots; bark; plant extracts; phytochemicals; triterpenoid saponins; chemical structure; spectral analysis; Texas
DOI:
10.1055/s-2005-864103
PubMed:
15856414

13. Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from Polygonum cuspidatum in PC12 Cells

Author:
Zhang, Zai Jun; Zhang, Huan; Zhang, Qing Wen,   et al.   ; Li, Ying Bo; Lin, Zhu Qing; Wang, Mei Wei; Lee, Simon Ming Yuen; Wang, Yi Tao; Hoi, Pui Man;     Show all 9 Authors
Source:
Planta medica 2011 v.77 no.4 pp. 354-361
ISSN:
0032-0943
Subject:
Reynoutria japonica; neuroprotective effect; Alzheimer disease; lipoic acid; cell viability; cytotoxicity; mitogen-activated protein kinase; reactive oxygen species; resveratrol; pathogenesis; oxidants; phosphorylation; lactate dehydrogenase; death; neurodegenerative diseases; antioxidant activity; apoptosis
Abstract:
... Much correlative evidence indicates that the oxidative modification of protein by reactive oxygen species (ROS) is involved in normal aging as well as the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. In this study, we explored the antioxidative and neuroprotective effects of a naphthoquinone, 2-methoxy-6-acetyl-7-methyljuglone (MAM), purified from the dried rhizome of Po ...
DOI:
10.1055/s-0030-1250385
PubMed:
20922651

14. Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model

Author:
Zhang, Peng; Zhang, Lian-Xue,   et al.   ; Wu, Qi; Zhao, Bo; Yang, Xiu-Wei; Xu, Wei; Zou, Lei;     Show all 7 Authors
Source:
Planta medica 2010 v.76 no.4 pp. 319-324
ISSN:
0032-0943
Subject:
medicinal plants; plant extracts; sesquiterpenoids; intestinal absorption; nutrient uptake; membrane permeability; bioassays; human cell lines; colon; adenocarcinoma; Oriental traditional medicine; herbal medicines; China
DOI:
10.1055/s-0029-1186195
PubMed:
19830652

15. Synergistic Anti-candidal Activity of Tetrandrine on Ketoconazole: an Experimental Study

Author:
Zhang, Hong; Zhang, Gehua,   et al.   ; Wang, Kaili; Ho, Hon In; Gao, Aili;     Show all 5 Authors
Source:
Planta medica 2010 v.76 no.1 pp. 53-61
ISSN:
0032-0943
Subject:
Candida albicans; vaginal diseases; disease control; ketoconazole; drug synergism; plant extracts; medicinal properties; phytochemicals; drug resistance; antifungal properties; dose response; animal models; mice
DOI:
10.1055/s-0029-1185973
PubMed:
19644794

16. GAP production of TCM herbs in China

Author:
Zhang, Bengang; Zhang, Zhao,   et al.   ; Peng, Yong; Liu, Haitao; Qi, Yaodong; Liu, Shuang; Xiao, Peigen;     Show all 7 Authors
Source:
Planta medica 2010 v.76 no.17 pp. 1948-1955
ISSN:
0032-0943
Subject:
Oriental traditional medicine; certification; drugs; herbs; China
Abstract:
... In this paper, we briefly review international Good Agricultural Practice (GAP) regulations related to traditional Chinese medicine herbs (TCM herbs) and the background of the drafting process and the implementation of GAP for TCM herbs in China. We also have summarized progress and achievements since the implementation of GAP for TCM herbs in 2002. Up to 2010, a total of 99 GAP bases were formall ...
DOI:
10.1055/s-0030-1250527
PubMed:
21077024

17. Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts

Author:
Zhang, Y.; Zhang, L.,   et al.   ; Zeng, X.; Zheng, X.;     Show all 4 Authors
Source:
Planta medica 2007 v.73 no.4 pp. 341-347
ISSN:
0032-0943
Subject:
enzyme activation; phosphatidylinositol 3-kinase; non-specific serine/threonine protein kinase; isoflavones; Pueraria montana var. lobata; human health; bone formation; osteoblasts; biochemical pathways; cultured cells; osteoporosis; rats; medicinal properties; protein phosphorylation; cell proliferation; alkaline phosphatase
DOI:
10.1055/s-2007-967168
PubMed:
17443435

18. Anti-asthmatic effects of Perilla seed oil in the guinea pig in vitro and in vivo

Author:
Zhang, S.J.; Zhang, H.,   et al.   ; Deng, Y.M.; Xie, Q.M.; Yao, H.Y.;     Show all 5 Authors
Source:
Planta medica 2007 v.73 no.1 pp. 53-58
ISSN:
0032-0943
Subject:
animal disease models; dose response; Perilla frutescens; seed oils; medicinal plants; human health; asthma; immune response; lungs; medicinal properties; leukotrienes; guinea pigs; Oriental traditional medicine
DOI:
10.1055/s-2006-957062
PubMed:
17315310

19. Three new jatrophone-type diterpenoids from Euphorbia helioscopia

Author:
Zhang, W.,   et al.   ; Guo, Y.W.;     Show all 2 Author
Source:
Planta medica 2005 v.71 no.3 pp. 283-286
ISSN:
0032-0943
Subject:
Euphorbia; medicinal plants; plant extracts; phytochemicals; diterpenoids; chemical structure; spectral analysis; stereochemistry
DOI:
10.1055/s-2005-837832
PubMed:
15770554

20. Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (EGb 761)

Author:
Zhang, Lantong,   et al.   ; Feng, Xiaolong; Zhu, Huiming;     Show all 3 Authors
Source:
Planta medica 2009 v.75 no.8 pp. 792-796
ISSN:
0032-0943
Subject:
terpenoids; kaempferol; lipid peroxidation; plant extracts; medicinal plants; glutathione; lactones; human health; spleen; isorhamnetin; animal disease models; Ginkgo biloba; cytotoxicity; superoxide dismutase; immune response; enzyme activity; antioxidant activity; glycosides; quercetin; catalase; thymus gland; anticarcinogenic activity
DOI:
10.1055/s-0029-1185451
PubMed:
19288403

21. Antibacterial lignans and triterpenoids from Rostellularia procumbens

Author:
Zhang, Y.; Zhang, Y.; Zhang, C.,   et al.   ; Bao, F.; Hu, J.; Liang, S.; Du, G.; Cheng, Y.;     Show all 8 Authors
Source:
Planta medica 2007 v.73 no.15 pp. 1596-1599
ISSN:
0032-0943
Subject:
humans; cytotoxicity; anticarcinogenic activity; medicinal plants; triterpenoids; lignans; cultured cells; spectral analysis; Justicia; chemical structure; Oriental traditional medicine; antibacterial properties; China
DOI:
10.1055/s-2007-993747
PubMed:
18058608

22. Detection of Valeriana jatamansi as an adulterant of medicinal Paris by length variation of chloroplast psbA-trnH region

Author:
Zhang, Fangming,   et al.   ; Yang, Ying; Zhai, Yanhong; Liu, Tao; Ji, Yunheng;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.1 pp. 87-91
ISSN:
0032-0943
Subject:
Melanthiaceae; Valeriana jatamansi; chloroplasts; electrophoresis; markets; raw materials; rhizomes; China
Abstract:
... Two varieties of Paris polyphylla Smith (Melanthiaceae), P. polyphylla Smith var. chinensis (Franch.) Hara, and P. polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz., are used as medicinal Paris in China. Their dried rhizomes are the major source of raw material for some medicines. In recent years, medicinal Paris has been found to be adulterated with Valeriana jatamansi Jones (Valerianaceae) ...
DOI:
10.1055/s-0030-1250072
PubMed:
20597045

23. Involvement of mitochondrial permeability transition pore opening in 7-xylosyl-10-deacetylpaclitaxel-induced apoptosis

Author:
Zhang, Yu,   et al.   ; Jiang, Shougang; Zu, Yuangang; Wang, Zhuo; Fu, Yuejie;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.10 pp. 1005-1012
ISSN:
0032-0943
Subject:
adenosine triphosphate; apoptosis; atomic force microscopy; calcium; cyclosporine; flow cytometry; hydrogen peroxide; membrane potential; mitochondria; paclitaxel; permeability; protein synthesis; toxicity
Abstract:
... 7-Xylosyl-10-deacetylpaclitaxel is a natural hydrophilic paclitaxel derivative. It has long been used in Chinese clinics to treat cancer. In order to further explore the underlying intracellular target of 7-xylosyl-10-deacetylpaclitaxel towards the PC-3 cell line, the ultra-structural morphology of mitochondria, the intracellular Ca2+, the intracellular ATP, the intracellular hydrogen peroxide and ...
DOI:
10.1055/s-0030-1270732
PubMed:
21294074

24. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats

Author:
Zhang, Yan,   et al.   ; Qi, Zhigang; Xue, Jie; Wang, Hengbin; Xie, Meilin;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.3 pp. 231-235
ISSN:
0032-0943
Subject:
adiponectin; agonists; animal models; blood glucose; blood serum; cholesterol; fasting; fatty liver; free fatty acids; homeostasis; inflammation; insulin; insulin resistance; liver; rats; triacylglycerols; weight gain
Abstract:
... The objectives of this study were to determine the effect of osthole on the insulin resistance (IR) in high-fat and high-sucrose-induced fatty liver rats and to investigate its potential mechanisms. The rat model was established by orally feeding high-fat and high-sucrose emulsion by gavage for 9 weeks. The experimental rats were treated with osthole 5 and 10 mg/kg, lipanthyl 30 mg/kg, and rosigli ...
DOI:
10.1055/s-0030-1250268
PubMed:
20717873

25. The role of Chinese medicine in the treatment of chronic diseases in China

Author:
Zhang, Chi,   et al.   ; Jiang, Miao; Cao, Hongxin; Chan, Kelvin; Lu, Aiping;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.9 pp. 873-881
ISSN:
0032-0943
Subject:
Oriental traditional medicine; biomarkers; chronic diseases; health services; patients; physicians; quality of life; randomized clinical trials; China
Abstract:
... Chinese medicine (CM) has a long history of experience and proven successful treatment for chronic diseases and has also played an important role in the provision of health care in China. Patients with chronic diseases are happy to accept CM and physicians are willing to use CM to relieve patients suffering from chronic illnesses. The Chinese health authorities encourage CM development to meet the ...
DOI:
10.1055/s-0030-1270983
PubMed:
21472645

26. Limonoids and diterpenoids from Toona ciliata Roem. var. yunnanensis

Author:
Zhang, Feng; Zhang, Chuan-Rui,   et al.   ; Liao, Shang-Gao; He, Xiu-Feng; Chen, Wan-Sheng; Yue, Jian-Min;     Show all 6 Authors
Source:
Planta medica 2011 v.77 no.14 pp. 1617-1622
ISSN:
0032-0943
Subject:
Toona ciliata; branches; diterpenoids; leaves; limonoids; spectroscopy
Abstract:
... Three new limonoids (toonaciliatins N−P, 1-3) and four new pimaradiene-type diterpenoids (toonacilidins A-D, 4-7) were isolated from the leaves and twigs of Toona ciliata Roem. var. yunnanensis. Their structures were elucidated on the basis of spectroscopic methods. Toonacilidin B (5) showed moderate inhibitory activity against H. pylori-SS1 with an MIC of 50 µg/mL. ...
DOI:
10.1055/s-0030-1270969
PubMed:
21472647

27. Pharmacokinetic study of borneol and menthol in rats after oral administration of Qingyan drop pills

Author:
Zhang, Shaozhuo; Zhang, Yanjun,   et al.   ; Xu, Yuefang; Li, Yubo; Hou, Jipeng; Xu, Yanyan; Wang, Yang; Liu, Changxiao; He, Xin;     Show all 9 Authors
Source:
Planta medica 2011 v.77 no.14 pp. 1600-1604
ISSN:
0032-0943
Subject:
bioactive properties; borneol; computer software; flame ionization; herbal medicines; liquid-liquid extraction; menthol; models; naphthalene; oral administration; pharmacokinetics; rats
Abstract:
... Both borneol and menthol are bioactive substances derived from Chinese herbal medicines. In order to understand the pharmacokinetics of borneol and menthol in Qingyan drop pills, a rapid, sensitive, and simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the simultaneous determination of borneol and menthol in rat plasma. Sample preparations were carried ...
DOI:
10.1055/s-0030-1270998
PubMed:
21484670

28. Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce

Author:
Zhang, Jianye; Zhang, Yonggang,   et al.   ; Xia, Xuekui; Li, Qing; Li, Jia; Shao, Changlun; Liu, Xin; Lin, Yongcheng; Liu, Changheng; She, Zhigang;     Show all 10 Authors
Source:
Planta medica 2011 v.77 no.15 pp. 1735-1738
ISSN:
0032-0943
Subject:
Nigrospora; antimicrobial properties; endophytes; fungi; griseofulvin; nuclear magnetic resonance spectroscopy; South China Sea
Abstract:
... Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2S,5′R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic fungus Nigrospora sp. (No. 14 ...
DOI:
10.1055/s-0030-1271040

29. Cytotoxic terpenoids from the fruits of Vitex trifolia L

Author:
Zhang, Shu-wei; Zhang, Xiao-hui,   et al.   ; Wu, Jun; Zhou, Tong; Xuan, Li-Jiang;     Show all 5 Authors
Source:
Planta medica 2009 v.75 no.4 pp. 367-370
ISSN:
0032-0943
Subject:
human diseases; monoterpenoids; cytotoxicity; medicinal plants; human health; Oriental traditional medicine; diterpenoids; spectral analysis; Vitex; cell cycle; apoptosis; chemical structure; stereochemistry; anticarcinogenic activity; China
DOI:
10.1055/s-0028-1112211
PubMed:
19156599

30. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities

Author:
Zhang, Ge; Zhang, Na,   et al.   ; Wang, Yu-Liang; Li, Run-Ping; Guo, Mei-Li; Ma, Yan-Li;     Show all 6 Authors
Source:
Planta medica 2009 v.75 no.3 pp. 230-235
ISSN:
0032-0943
Subject:
Petasites; medicinal plants; Oriental traditional medicine; sesquiterpenoid lactones; chemical structure; spectral analysis; stereochemistry; neuroprotective effect; antioxidant activity; rats; cerebral cortex; neurons; cultured cells; animal models; human health
DOI:
10.1055/s-0028-1088377
PubMed:
19085813

31. Isolation and characterization of a novel trypsin inhibitor from fresh lily bulbs

Author:
Zhang, X.,   et al.   ; Wang, H.; Ng, T.B.;     Show all 3 Authors
Source:
Planta medica 2008 v.74 no.5 pp. 546-550
ISSN:
0032-0943
Subject:
antiviral properties; trypsin inhibitors; humans; anticarcinogenic activity; macrophages; antifungal properties; medicinal plants; amino acid sequences; mice; Lilium; cultured cells; plant pathogenic fungi; cell proliferation; Oriental traditional medicine; plant proteins
DOI:
10.1055/s-2008-1074502
PubMed:
18401842

32. Isolation and Cytotoxic Activity of Selaginellin Derivatives and Biflavonoids from Selaginella tamariscina

Author:
Zhang, Guo-gang; Zhang, Hong-mei,   et al.   ; Jing, Ying; Ma, En-long; Guan, Jin; Xue, Feng-ning; Liu, Hong-xia; Sun, Xiao-ya;     Show all 8 Authors
Source:
Planta medica 2012 v.78 no.4 pp. 390-392
ISSN:
0032-0943
Subject:
Selaginella; breast neoplasms; carcinoma; cytotoxicity; humans; spectroscopy
Abstract:
... Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin (6), hinokiflavone (7), pulvinatabiflavone (8), and 7′′-O-methyl ...
DOI:
10.1055/s-0031-1298175
PubMed:
22271084

33. Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production

Author:
Zhang, Shou-De; Zhang, Wei-Dong,   et al.   ; Qin, Jiang-Jiang; Jin, Hui-Zi; Yin, Yin-Hua; Li, Hong-Lin; Yang, Xian-Wen; Li, Xia; Shan, Lei;     Show all 9 Authors
Source:
Planta medica 2012 v.78 no.2 pp. 166-171
ISSN:
0032-0943
Subject:
Inula racemosa; inhibitory concentration 50; macrophages; nitric oxide; roots; sesquiterpenoids; spectroscopy
Abstract:
... A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the resul ...
DOI:
10.1055/s-0031-1280294
PubMed:
22002850

34. Norsesquiterpene derivatives from the roots of Ligularia fischeri

Author:
Zhang, Wen-Juan,   et al.   ; Qi, Huan-Yang; Shi, Yan-Ping;     Show all 3 Authors
Source:
Planta medica 2010 v.76 no.2 pp. 159-164
ISSN:
0032-0943
Subject:
Ligularia; medicinal plants; roots; chemical constituents of plants; sesquiterpenoids; medicinal properties; spectral analysis; chemical structure; plant extracts; biosynthesis; biochemical pathways; China
DOI:
10.1055/s-0029-1186036
PubMed:
19670156

35. The neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats

Author:
Zhang, S.; Zhang, L.,   et al.   ; Xu, X.; Yan, W.; Zheng, X.;     Show all 5 Authors
Source:
Planta medica 2005 v.71 no.7 pp. 585-591
ISSN:
0032-0943
Subject:
neuroprotective effect; ischemia; messenger RNA; isoflavones; Pueraria montana var. lobata; caspases; medicinal plants; plant extracts; nucleotide sequences; rats; enzyme activity; gene expression regulation; apoptosis; cerebrovascular disorders
DOI:
10.1055/s-2005-871261
PubMed:
16041641

36. Compounds from Platycladus orientalis and their inhibitory effects on nitric oxide and TNF-α production

Author:
Zhang, Shou-De; Zhang, Wei-Dong,   et al.   ; Fan, Si-Yang; Pei, Yue-Hu; Zeng, Hua-Wu; Li, Yong-Li; Li, Li; Ye, Ji; Pan, Yue-Xin; Li, Hong-Lin;     Show all 10 Authors
Source:
Planta medica 2011 v.77 no.14 pp. 1623-1630
ISSN:
0032-0943
Subject:
Platycladus orientalis; bioassays; diterpenoids; glycosides; inhibitory concentration 50; leaves; nitric oxide; nuclear magnetic resonance spectroscopy; phenol; tumor necrosis factor-alpha
Abstract:
... Four new compounds: an abietane (1), two isopimarane (2 and 3) diterpenes, and a dihydrobenzofuran neolignan (5), together with a sesquiterpene glycoside (6) firstly isolated from a natural source, and a known phenol glycoside (4) were isolated from leaves of Platycladus orientalis. The structures and relative configurations of these compounds were assigned on the basis of MS, IR, 1D and 2D NMR da ...
DOI:
10.1055/s-0030-1270905
PubMed:
21412696

37. Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits

Author:
Zhang, Yuqin; Zhang, Ling,   et al.   ; Shao, Meng; Qu, Kai; Liu, Ke; Lian, Zeqin; Chen, Tingting; Liu, Junfeng; Wu, Aili; Tang, Yue; Zhu, Haibo;     Show all 11 Authors
Source:
Planta medica 2011 v.77 no.8 pp. 809-816
ISSN:
0032-0943
Subject:
alanine transaminase; alkaline phosphatase; aspartate transaminase; bilirubin; biomarkers; blood serum; creatinine; dexamethasone; heart; heart rate; histopathology; interleukin-1beta; intravenous injection; kidneys; lactate dehydrogenase; lipopolysaccharides; liver; lungs; necrosis; nitric oxide; protective effect; rabbits; radioimmunoassays; temperature; tumor necrosis factor-alpha; urea nitrogen
Abstract:
... In this study, we investigated the protective effects of ligustilide against lipopolysaccharide (LPS)-induced endotoxic shock in Japanese white rabbits and attempted to elucidate the possible mechanism underlying these effects. Forty-two rabbits were randomized into 6 groups: normal group, LPS group, dexamethasone group (5 mg/kg), and 3 ligustilide groups (20, 40, and 80 mg/kg). After the rabbits ...
DOI:
10.1055/s-0030-1250573
PubMed:
21104607

38. Two pairs of epimeric indole alkaloids from Catharanthus roseus

Author:
Zhang, Dong-Mei; Zhang, Xiao-Qi,   et al.   ; Wang, Guo-Cai; Zhong, Xiang-Zhan; Wang, Ying; Jiang, Ren-Wang; Li, Yao-Lan; Wang, Jiao; Yao, Xin-Sheng; Ye, Wen-Cai;     Show all 10 Authors
Source:
Planta medica 2011 v.77 no.15 pp. 1739-1741
ISSN:
0032-0943
Subject:
Catharanthus roseus; X-ray diffraction; chlorine; cytotoxicity; human cell lines; indole alkaloids; nuclear magnetic resonance spectroscopy
Abstract:
... Two pairs of epimeric indole alkaloids (1-4) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 1-4 against the HepG2 cell line were evaluated. ...
DOI:
10.1055/s-0030-1271064
PubMed:
21544775

39. Two new cytotoxic triterpene glycosides from the sea cucumber Holothuria scabra

Author:
Zhang, Hongwei,   et al.   ; Han, Hua; Yi, Yanghua; Xu, Qiangzhi; La, Mingping;     Show all 5 Authors
Source:
Planta medica 2009 v.75 no.15 pp. 1608-1612
ISSN:
0032-0943
Subject:
Holothuroidea; aquatic invertebrates; chemical composition; triterpenoids; glycosides; medicinal properties; cytotoxicity; human cell lines; antineoplastic agents; South China Sea
DOI:
10.1055/s-0029-1185865
PubMed:
19598081

40. New alkaloids from Forsythia suspensa and their anti-inflammatory activities

Author:
Zhang, De-Wu,   et al.   ; Dai, Sheng-Jun; Ren, Yan; Shen, Li;     Show all 4 Authors
Source:
Planta medica 2009 v.75 no.4 pp. 375-377
ISSN:
0032-0943
Subject:
anti-inflammatory activity; alkaloids; Forsythia suspensa; medicinal plants; Oriental traditional medicine; chemical structure; neutrophils; human health; spectral analysis; rats; enzyme inhibition; beta-glucuronidase; stereochemistry; China
DOI:
10.1055/s-0028-1112204
PubMed:
19148863

41. In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa

Author:
Zhang, Li-hua; Zhang, Yu-kui,   et al.   ; Wang, Xiao-na; Xu, Li-na; Peng, Jin-yong; Liu, Ke-xin;     Show all 6 Authors
Source:
Planta medica 2009 v.75 no.11 pp. 1215-1220
ISSN:
0032-0943
Subject:
Coptis; Euodia; medicinal plants; synergism; anticarcinogenic activity; spleen; lymphocytes; cell proliferation; tumor necrosis factor-alpha; apoptosis; human diseases; human health
DOI:
10.1055/s-0029-1185538
PubMed:
19350478

42. Cytotoxicity and phytotoxicity of trichothecene macrolides from Myrothecium gramminum

Author:
Zhang, Yu Fei; Zhang, Jie,   et al.   ; Ge, Hui Ming; Jiao, Rui Hua; Wang, Yu Rong; Tan, Ren Xiang;     Show all 6 Authors
Source:
Planta medica 2009 v.75 no.3 pp. 227-229
ISSN:
0032-0943
Subject:
hepatocytes; endophytes; humans; phytotoxicity; cytotoxicity; Echinochloa crus-galli; cultured cells; macrolides; trichothecenes; Myrothecium; anticarcinogenic activity
DOI:
10.1055/s-0028-1112196
PubMed:
19097001

43. Flavonoids, coumarins and triterpenes from the aerial parts of Cnidoscolus texanus

Author:
Zhang, Z.; Zhang, W.,   et al.   ; Yuan, W.; Li, S.; Ownby, S.; Wang, P.; Beasley, R.S.;     Show all 7 Authors
Source:
Planta medica 2007 v.73 no.12 pp. 1304-1308
ISSN:
0032-0943
Subject:
phytosterols; naringenin; coumaric acids; triterpenoids; Cnidoscolus; coumarins; spectral analysis; chemical structure; Texas
DOI:
10.1055/s-2007-990226
PubMed:
17893826

44. Effects of fucoidan on chronic renal failure in rats

Author:
Zhang, Q.B.; Zhang, H.,   et al.   ; Li, Z.; Xu, Z.H.; Niu, X.Z.;     Show all 5 Authors
Source:
Planta medica 2003 v.69 no.6 pp. 537-541
ISSN:
0032-0943
Subject:
albumins; renal failure; blood serum; creatine; phytochemicals; algae; protein content; body weight; fucoidan; medicinal plants; disease control; animal models; Laminaria; kidneys; urea nitrogen; histopathology; rats
DOI:
10.1055/s-2003-40634
PubMed:
12865973

45. Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice

Author:
Zhang, Bing,   et al.   ; Liao, You-Jiao; Zhai, Hai-Feng; Duan, Tian-Xuan; Huang, Jian-Mei;     Show all 5 Authors
Source:
Planta medica 2011 v.77 no.5 pp. 416-420
ISSN:
0032-0943
Subject:
Juncus effusus; locomotion; phenanthrenes; mice; herbal medicines; sedatives
Abstract:
... Dehydroeffusol, a phenanthrene isolated from Juncus effusus L., possesses characteristic anxiolytic and sedative properties, as determined by an array of behavioral tests in mice. In the elevated plus-maze test, dehydroeffusol significantly increased the number of entries into the open arms and the time the mice spent in these arms in a dose-dependent manner, with a minimum effective dose of 2.5 m ...
DOI:
10.1055/s-0030-1250517
PubMed:
21104609

46. Chemotype-dependent metabolic response to methyl jasmonate elicitation in Artemisia annua

Author:
Zhang, Qing,   et al.   ; Wu, Wei; Yuan, Man; Zhu, Yanming; Yong, Li; Wang, Wei; Qi, Yan; Guo, Dianjing;     Show all 8 Authors
Source:
Planta medica 2011 v.77 no.10 pp. 1048-1053
ISSN:
0032-0943
Subject:
Artemisia annua; aldehydes; artemisinin; biosynthesis; chemotypes; cytochrome P-450; enzymes; gene expression; gene expression regulation; genes; germacrene; messenger RNA; methyl jasmonate; oxidation; reverse transcriptase polymerase chain reaction; squalene
Abstract:
... Considerable difference in artemisinin and its direct precursors, artemisinic acid and dihydroartemisinic acid, was detected between two chemotypes within the species Artemisia annua (A. annua). These two chemotypes showed differential metabolic response to methyl jasmonate (MeJA) elicitation. Exogenous application of MeJA resulted in an accumulation of dihydroartemisinic acid and artemisinin in T ...
DOI:
10.1055/s-0030-1250744
PubMed:
21267809

47. Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase

Author:
Zhang, Qian,   et al.   ; Zhou, Dan-yang; Du, Qiang; Li, Ruo-ran; Huang, Mao; Wei, Guo-zhen;     Show all 6 Authors
Source:
Planta medica 2011 v.77 no.14 pp. 1575-1581
ISSN:
0032-0943
Subject:
animal models; antioxidants; asthma; blood serum; goblet cells; grape seeds; immunoglobulin E; inducible nitric oxide synthase; inflammation; interferons; interleukin-13; mice; nitric oxide; ovalbumin
Abstract:
... Allergic asthma is characterized by hyperresponsiveness and inflammation of the airway with increased expression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide (NO). Grape seed proanthocyanidin extract (GSPE) has been proved to have antioxidant, antitumor, anti-inflammatory, and other pharmacological effects. The purpose of this study was to examine the role of GSPE o ...
DOI:
10.1055/s-0030-1270957
PubMed:
21452107

48. Sesquiterpenoid and Phenolic Glucoside Gallates from Lagerstroemia balansae

Author:
Zhang, Qing-ying,   et al.   ; Zhou, Yong; Chen, Hu-biao; Wang, Bin; Liang, Hong; Zhao, Yu-ying;     Show all 6 Authors
Source:
Planta medica 2011 v.77 no.17 pp. 1944-1946
ISSN:
0032-0943
Subject:
Lagerstroemia; spectroscopy; stems
Abstract:
... Three new compounds, including a sesquiterpenoid glucoside gallate, 2Z,4E,1'R,2'S,4'R,6'S-dihydrophaseic acid 4'-O-(6"-O-galloyl)-beta-D-glucopyranoside (1), two new phenolic glucoside gallates, 4-hydroxy-3,5-dimethoxybenzoic acid 4-O-(6'-O-galloyl)-beta-D-glucopyranoside (2) and 3,4-dimethoxyphenol 1-O-(6'-O-galloyl)-beta-D-glucopyranoside (3), together with eight known compounds (4-11), have bee ...
DOI:
10.1055/s-0031-1280093
PubMed:
21800279

49. Purification and biochemical characterization of a novel allergenic protein from tatary buckwheat seeds

Author:
Zhang, Xin,   et al.   ; Cui, Xiaodong; Li, Yuying; Wang, Zhuanhua;     Show all 4 Authors
Source:
Planta medica 2008 v.74 no.15 pp. 1837-1841
ISSN:
0032-0943
Subject:
buckwheat; Fagopyrum tataricum; seeds; allergens; human health; immune response; food allergies; plant proteins
DOI:
10.1055/s-0028-1088319
PubMed:
19031360

50. Steroids, alkaloids, and coumarins from Gelsemium sempervirens

Author:
Zhang, Zhizhen,   et al.   ; Wang, Ping; Yuan, Wei; Li, Shiyou;     Show all 4 Authors
Source:
Planta medica 2008 v.74 no.15 pp. 1818-1922
ISSN:
0032-0943
Subject:
Gelsemium sempervirens; steroids; alkaloids; coumarins; enzyme inhibition; DNA topoisomerase; humans; chemical structure; spectral analysis
DOI:
10.1055/s-0028-1088327
PubMed:
19016214