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- Yang, Xiaojuan; Zhang, Yin; Hosaka, Kayoko; Andersson, Patrik; Wang, Jian; Tholander, Fredrik; Cao, Ziquan; Morikawa, Hiromasa; Tegnér, Jesper; Yang, Yunlong; Iwamoto, Hideki; Lim, Sharon; Cao, Yihai
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. E2900
- cell invasion; cytokines; metastasis; mortality; neoplasm cells; neoplasms; new drugs; patients; prognosis; vascular endothelial growth factor B
- ... The biological functions of VEGF-B in cancer progression remain poorly understood. Here, we report that VEGF-B promotes cancer metastasis through the remodeling of tumor microvasculature. Knockdown of VEGF-B in tumors resulted in increased perivascular cell coverage and impaired pulmonary metastasis of human melanomas. In contrast, the gain of VEGF-B function in tumors led to pseudonormalized tumo ...
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- Hopkins, Kaycie C.; Tartell, Michael A.; Herrmann, Christin; Hackett, Brent A.; Taschuk, Frances; Panda, Debasis; Menghani, Sanjay V.; Sabin, Leah R.; Cherry, Sara
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. E2920
- Orthobunyavirus; Rift Valley fever virus; humans; interferons; messenger RNA; translation (genetics)
- ... The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts. In response, RVFV inhibits two well-known antiviral pathways that attenuate translation during infection, PKR and type I IFN signaling. Despite this, translational arrest occurs durin ...
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