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- Kim, Dal Young; Atasheva, Svetlana; McAuley, Alexander J.; Plante, Jessica A.; Frolova, Elena I.; Beasley, David W. C.; Frolov, Ilya
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.29 pp. 10708-10713
- RNA; RNA replication; Venezuelan equine encephalitis virus; West Nile virus; clones; complementary DNA; cytoplasm; enzymes; heterologous gene expression; immunization; mice; neutralizing antibodies; protein synthesis; proteins; replicon; structural genes
- ... Since the development of infectious cDNA clones of viral RNA genomes and the means of delivery of the in vitro-synthesized RNA into cells, alphaviruses have become an attractive system for expression of heterologous genetic information. Alphaviruses replicate exclusively in the cytoplasm, and their genetic material cannot recombine with cellular DNA. Alphavirus genome-based, self-replicating RNAs ...
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