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- Brudno, Yevgeny; Silva, Eduardo A.; Kearney, Cathal J.; Lewin, Sarah A.; Miller, Alex; Martinick, Kathleen D.; Aizenberg, Michael; Mooney, David J.
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.35 pp. 12722-12727
- alginate gels, etc ; blood; drug delivery systems; drugs; hydrocolloids; neoplasms; oligodeoxyribonucleotides; tissue repair; tissues; Show all 9 Subjects
- ... Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is exhausted. Inspired by the ability of nanotherapeutics to target specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to and refill hydrogel drug delivery systems. To address this possibility, hydrogels wer ...
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- Nagarajan, Saisubramanian; Kruckeberg, Arthur L.; Schmidt, Karen H.; Kroll, Evgueny; Hamilton, Morgan; McInnerney, Kate; Summers, Ryan; Taylor, Timothy; Rosenzweig, Frank
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.15 pp. E1538
- calcium alginate, etc ; Saccharomyces cerevisiae; bioreactors; cell cycle; cell walls; cyclins; eukaryotic cells; gene expression regulation; genes; glycolysis; heat; immobilized cells; longevity; low calorie diet; phenotype; reproduction; stress tolerance; transcription factors; tricarboxylic acid cycle; viability; yeasts; Show all 21 Subjects
- ... Studies of replicative and chronological lifespan in Saccharomyces cerevisiae have advanced understanding of longevity in all eukaryotes. Chronological lifespan in this species is defined as the age-dependent viability of nondividing cells. To date this parameter has only been estimated under calorie restriction, mimicked by starvation. Because postmitotic cells in higher eukaryotes often do not s ...
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