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You searched for: Journal Proceedings of the National Academy of Sciences of the United States of America Remove constraint Journal: Proceedings of the National Academy of Sciences of the United States of America Publication Year 2013 Remove constraint Publication Year: 2013 Source 2013 v.110 no.28 Remove constraint Source: 2013 v.110 no.28 Subject models Remove constraint Subject: models Subject gene expression Remove constraint Subject: gene expression
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1. Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner

Author:
Kocatürk, Begüm; Van den Berg, Yascha W.; Tieken, Chris; Mieog, J. Sven D.; de Kruijf, Esther M.; Engels, Charla C.; van der Ent, Martijn A.; Kuppen, Peter J.; Van de Velde, Cornelis J.; Ruf, Wolfram; Reitsma, Pieter H.; Osanto, Susanne; Liefers, Gerrit-Jan; Bogdanov, Vladimir Y.; Versteeg, Henri H.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.28 pp. 11517-11522
ISSN:
0027-8424
Subject:
CD29 antigen; alternative splicing; autocrine signaling; breast neoplasms; cell proliferation; coagulation; gene expression; hemostasis; models; stems
Abstract:
... Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression. We are unique in reporting that asTF, but not flTF, strongly associates with bot ...
DOI:
10.1073/pnas.1307100110
PubMed:
23801760
PubMed Central:
PMC3710867

2. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery

Author:
Guénard, Frédéric; Deshaies, Yves; Cianflone, Katherine; Kral, John G.; Marceau, Picard; Vohl, Marie-Claude
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.28 pp. 11439-11444
ISSN:
0027-8424
Subject:
adulthood; adults; children; fasting; gastrointestinal system; gene expression; genes; insulin; insulin resistance; methylation; models; mothers; obesity; phenotype; pregnancy; risk; siblings; surgery; transcriptome; weight loss
Abstract:
... Obesity and overnutrition during pregnancy affect fetal programming of adult disease. Children born after maternal bariatric gastrointestinal bypass surgery (AMS) are less obese and exhibit improved cardiometabolic risk profiles carried into adulthood compared with siblings born before maternal surgery (BMS). This study was designed to analyze the impact of maternal weight loss surgery on methylat ...
DOI:
10.1073/pnas.1216959110
PubMed:
23716672
PubMed Central:
PMC3710842

3. Tuning gene expression with synthetic upstream open reading frames

Author:
Ferreira, Joshua P.; Overton, K. Wesley; Wang, Clifford L.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.28 pp. 11284-11289
ISSN:
0027-8424
Subject:
RNA; RNA libraries; engineering; gene expression; mammals; models; open reading frames; protein synthesis; recombinant proteins; ribosomes; start codon
Abstract:
... We engineered short ORFs and used them to control the expression level of recombinant proteins. These short ORFs, encoding a two-amino acid peptide, were placed upstream of an ORF encoding a protein of interest. Insertion of these upstream ORFs (uORFs) resulted in suppression of protein expression. By varying the base sequence preceding the uORF, we sought to vary the translation initiation rate o ...
DOI:
10.1073/pnas.1305590110
PubMed:
23798422
PubMed Central:
PMC3710870