Jump to Main Content
- Hall, John C.; Casciola-Rosen, Livia; Berger, Alan E.; Kapsogeorgou, Efstathia K.; Cheadle, Chris; Tzioufas, Athanasios G.; Baer, Alan N.; Rosen, Antony
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.43 pp. 17609-17614
- biopsy, etc ; dermatomyositis; disease surveillance; epithelial cells; interferon-alpha; interferon-gamma; muscles; pathogenesis; patients; proteins; tissues; Show all 11 Subjects
- ... Elucidating the molecular pathways active in pathologic tissues has important implications for defining disease subsets, selecting therapy, and monitoring disease activity. The development of therapeutics directed at IFN-α or IFN-γ makes the discovery of probes that report precisely on the activity of different IFN pathways a high priority. We show that, although type I and II IFNs induce the expr ...
- PubMed Central:
- Schito, Luana; Rey, Sergio; Tafani, Marco; Zhang, Huafeng; Wong, Carmen Chak-Lui; Russo, Andrea; Russo, Matteo A.; Semenza, Gregg L.
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.40 pp. E2707
- biopsy, etc ; angiogenesis; breast neoplasms; chemotaxis; clinical trials; digoxin; endothelial cells; genes; humans; hypoxia-inducible factor 1; immunohistochemistry; metastasis; mice; mortality; neoplasm cells; patients; platelet-derived growth factor; transcriptional activation; tyrosine; Show all 19 Subjects
- ... Lymphatic dissemination from the primary tumor is a major mechanism by which breast cancer cells access the systemic circulation, resulting in distant metastasis and mortality. Numerous studies link activation of hypoxia-inducible factor 1 (HIF-1) with tumor angiogenesis, metastasis, and patient mortality. However, the role of HIF-1 in lymphatic dissemination is poorly understood. In this study, w ...
- PubMed Central: