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- Lee, Moo-Yeal; Kumar, R. Anand; Sukumaran, Sumitra M.; Hogg, Michael G.; Clark, Douglas S.; Dordick, Jonathan S.
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.1 pp. 59-63
- alginate gels, etc ; cell culture; collagen; cytotoxicity; drugs; glass; humans; inhibitory concentration 50; liver; metabolites; microarray technology; screening; Show all 12 Subjects
- ... We have developed a miniaturized 3D cell-culture array (the Data Analysis Toxicology Assay Chip or DataChip) for high-throughput toxicity screening of drug candidates and their cytochrome P450-generated metabolites. The DataChip consists of human cells encapsulated in collagen or alginate gels (as small as 20 nl) arrayed on a functionalized glass slide for spatially addressable screening against m ...
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