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- Ying, Chunxiao; Li, Ying; Leung, Chung-Hang; Robek, Michael D.; Cheng, Yung-Chi
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.20 pp. 8526-8531
- DNA; DNA replication; RNA; cytotoxicity; gene expression; gene expression regulation; protein synthesis; transcription factors; viral proteins; viruses
- ... Helioxanthin is a natural product that inhibits the replication of a number of viruses. We found that a previously undescribed helioxanthin analogue, 8-1, exhibited potent anti-hepatitis B virus (HBV) activity with little cytotoxicity. 8-1 suppressed both HBV RNA and protein expression, as well as DNA replication of both wild-type and 3TC-resistant virus. Time-course analyses revealed that RNA exp ...
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