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- Chen, Xin Jie; Wang, Xiaowen; Butow, Ronald A.
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.34 pp. 13738-13743
- aconitate hydratase; binding proteins; iron absorption; messenger RNA; mitochondria; mitochondrial DNA; point mutation; single-stranded DNA; tricarboxylic acid cycle; yeasts
- ... Aconitase (Aco1p) is a multifunctional protein: It is an enzyme of the tricarboxylic acid cycle. In animal cells, Aco1p also is a cytosolic protein binding to mRNAs to regulate iron metabolism. In yeast, Aco1p was identified as a component of mtDNA nucleoids. Here we show that yeast Aco1p protects mtDNA from excessive accumulation of point mutations and ssDNA breaks and suppresses reductive recomb ...
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