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- Cui, Yan, et al. Show all 14 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.30 pp. 12353-12358
- DNA methylation; GTPase-activating proteins; calcium; carcinogenesis; epigenetics; growth retardation; guanosinetriphosphatase; humans; mutation; neoplasm cells; neoplasms; oncogenes; receptors; tumor suppressor genes
- ... Ras has achieved notoriety as an oncogene aberrantly activated in multiple human tumors. Approximately 30% of all human tumors express an oncogenic form of this GTPase that is locked in an active conformation as a result of being insensitive to Ras GTPase-activating proteins (GAPs), proteins that normally regulate the inactivation of Ras by enhancing its intrinsic GTPase activity. Besides oncogeni ...
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