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- Jamieson, P., et al. Show all 10 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2006 v.103 no.44 pp. 16580-16585
- carbohydrate metabolism; high fat diet; glucose; skeletal muscle; mice; hormonal regulation; corticotropin-releasing hormone; musculoskeletal system physiology; insulin; homeostasis; lean body mass
- ... Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is a major site of peripheral insulin resistance. Urocortin 2 (Ucn 2), a member of the corticotropin-releasing factor (CRF) family, and its cognate type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn 2, we generated mice that are deficient in t ...
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