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- Vodovar, N.; Vinals, M.; Liehl, P.; Basset, A.; Degrouard, J.; Spellman, P.; Boccard, F.; Lemaitre, B.
- Proceedings of the National Academy of Sciences of the United States of America 2005 v.102 no.32 pp. 11414-11419
- immune response, etc ; Drosophila melanogaster; bacterial infections; entomopathogenic bacteria; Pseudomonas; ingestion; gene expression; messenger RNA; microarray technology; transcription (genetics); disease resistance; resistance mechanisms; nucleotide sequences; genes; ribosomal RNA; host-pathogen relationships; pathogenicity; Show all 17 Subjects
- ... Drosophila has been shown to be a valuable model for the investigation of host-pathogen interactions. Study of the Drosophila immune response has been hampered, however, by the lack of true Drosophila pathogens. In nearly all studies reported, the bacteria used were directly injected within the body cavity of the insect, bypassing the initial steps of a natural interaction. Here, we report the ide ...
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- Thoetkiattikul, H.; Beck, M.H.; Strand, M.R.
- Proceedings of the National Academy of Sciences of the United States of America 2005 v.102 no.32 pp. 11426-11431
- immune response, etc ; Microplitis demolitor bracovirus; viral proteins; genome; genes; nucleotide sequences; amino acid sequences; gene expression regulation; transcription factors; transcription (genetics); binding capacity; promoter regions; host-pathogen relationships; Drosophila melanogaster; cell lines; Show all 15 Subjects
- ... Complex signaling pathways regulate the innate immune system of insects, with NF-kappaB transcription factors playing a central role in the activation of antimicrobial peptides and other immune genes. Although numerous studies have characterized the immune responses of insects to pathogens, comparatively little is known about the counterstrategies pathogens have evolved to circumvent host defenses ...
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